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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 25 for “"Single nucleotide polymorphisms (SNP)"”.

  1. Reconstruction of major male and female lineages of the Strand Muslim community

    Geduld, TasneemUniversity of the Western Cape2010

    … mini-sequencing technique was used to genotype single nucleotide polymorphisms (SNP) on the Y-chromosome and mitochondrial DNA in 115 males from the Strand Muslim community.

    western-cape Repository record

  2. Towards constructing disease relationship networks using genome-wide association studies

    Huang, WenhuiVirginia Tech2009

    … by exploiting network analysis to study the single nucleotide polymorphisms (SNP) effect on the similarity between different diseases. Proteins within perturbation subnetwork are considered to be connection points between the disease similarity networks. Results: shared disease subnetwork …

    vt Repository record

  3. Insights on the Regulation of the PERIOD 2 Gene in the Cellular Response to DNA Damage

    Jiang, LiangVirginia Tech2019

    … is independent of p53. In addition, we analyzed Single Nucleotide Polymorphisms (SNP) of PER2 in the 1000 Genome project to gain insight onto how missense mutations in PER2 lay at the interface of p53:PER2 binding. In a separate project, we also performed bioinformatics analysis on the iron …

    vt Repository record

  4. FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S.

    Shukry, Sally Gamal2017

    … FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Biology at Virginia …

    vcu Repository record

  5. An exploratory analysis of large health cohort study using Bayesian networks

    Shen, DelinMassachusetts Institute of Technology2006

    … breast cancer risk factors, including a group of Single Nucleotide Polymorphisms (SNP). We found no association between the SNPs and breast cancer, but found a dependency between clomid and breast cancer. We evaluated clomid as a potential riskfactor after matching on age and number of children. …

    mit Repository record

  6. Bayesian variable selection for linear mixed models when p is much larger than n with applications in genome wide association studies

    Williams, Jacob Robert MichaelVirginia Tech2023

    … association studies (GWAS) seek to identify single nucleotide polymorphisms (SNP) causing phenotypic responses in individuals. Commonly, GWAS analyses are done by using single marker association testing (SMA) which investigates the effect of a single SNP at a time and selects a candidate set …

    vt Repository record

  7. Effects of single nucleotide polymorphisms in leptin and pro-opiomelanocortin on peripheral eucocyte counts in beef cattle

    Asiamah, Patience AgyarkoUniversity of Saskatchewan2005

    Single nucleotide polymorphisms (SNP) in leptin (LEP) and pro-opiomelanocortin (POMC) have been associated with beef carcass quality and yield respectively. Both hormones also play a role in immune performance. Since both of these genes are pleiotrophic, it was important to determine whether …

    sask Repository record

  8. Determinanti genetici dell’espressione dell’emoglobina HbF

    MANUNZA, LAURAUniversità degli Studi di Cagliari2016

    … of fetal hemoglobin (HPFH) and two new predicted polymorphisms (HBE1 rs67385638; HBG2 rs2855122) involved in the increased HbF and HbA2 levels. Methods: We selected 4 cohorts of samples with different phenotypes: 87 HPFH, 41 subjects with normal HbF levels, 395 patients with beta thalassemia major …

    cagliari Repository record

  9. Variable selection for generalized linear mixed models and non-Gaussian Genome-wide associated study data

    Xu, ShuangshuangVirginia Tech2024

    … study (GWAS) aims to identify associated single nucleotide polymorphisms (SNP) for phenotypes. SNP has the characteristic that the number of SNPs is from hundred of thousands to millions. If p is the number of SNPs and n is the sample size, it is a p>>n variable selection problem. To solve …

    vt Repository record

  10. Computational methods for inferring regulatory mechanisms from sequence and expression variation

    Xie, XiaomanUniversity of Illinois at Urbana-Champaign2022

    … Restarts” algorithm on a network composed of single-nucleotide polymorphisms (SNP), genes and pathways to associate pathways to a given set of variants. In Chapter 4, we analyze the mechanisms of another group of gene expression regulators: long non-coding RNAs or lncRNAs. With lncRNA-mRNA …

    uiuc Repository record

  11. Biomarkers of fat intake

    Alhilal, MaryamKing's College London2013

    … explored the effects of variations in single nucleotide polymorphisms (SNP) in the fatty acid desaturase (FADS) genes on the fatty acid composition of the biomarkers. Polymorphism in FADS1 rs174537 explained some of this variation. Carriage of the minor allele of rs174537 SNP also …

    kings Repository record

  12. Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome

    Shortt, Katherine AnneUniversity of Missouri--Kansas City2014

    … we have tentatively identified a number of single nucleotide polymorphisms (SNP) which are potentially associated with ARDS. In this study, we validated three SNPs (rs78142040, rs9605146, and rs3848719) in an additional 117 ARDS patients using TaqMan SNP genotyping assays (Life Technologies) …

    umkc Repository record

  13. A Pilot Study- Identify Genetic Variants for Diabetic Cataract Using GoDARTS Dataset

    Zhang, KaidaUniversity of Dundee2016

    … dataset. We set the significant P value of Single Nucleotide Polymorphisms (SNP) in the project as 10−6, there are 7 associated Single Nucleotide Polymorphisms in the range of genome-wide significance we set, including rs10197646 (P 4.12x10-7), chr13:48026216:D (P 4.15x10-7), rs7582173 (P …

    dundee Repository record

  14. Large Scale Machine Learning in Biology

    Raj, Anil2011

    … of predicting disease risk in humans using single nucleotide polymorphisms (SNP) -- single-base pair variations -- in their entire genome. While genome-wide association studies usually aim to infer individual SNPs that are strongly associated with disease, we use popular supervised learning …

    columbia-diss Repository record

  15. GENETIC ANALYSIS OF SELECTED SEED CONSTITUENT TRAITS IN CHICKPEA (Cicer arietinum L.)

    Wang, RunfengUniversity of Saskatchewan2016

    … population analyzed by GBS identified 415 single nucleotide polymorphisms (SNP) that identified eight linkage groups. Six quantitative trait loci (QTLs) for TSW explained 2.5 – 24.6 % of total variance, four QTLs explained 2.5 – 19.4 % of phenotypic variance for protein and one QTL for …

    sask Repository record

  16. Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.

    Al Ali, Fatima MohamedRobert Gordon University2016

    … i) a bioinformatics approach to determine what single nucleotide polymorphisms (SNP) may occur within the NFĸB1 gene in T2DM and ii) a molecular biology approach to investigate the role of the SNP of interest in a human monocyte cell line using polymerase chain reaction (PCR) and restriction …

    rgu Repository record

  17. Molecular and biochemical characterisation of esterases from oenococcus oeni and their potential for application in wine.

    Sumby, Krista Mary2013

    … strains with „low‟ whole cell activity through single nucleotide polymorphisms (SNP). This study will improve the understanding of the functioning of LAB esterases in wine conditions and the reason for strain specific differences in activity, with a view towards modulating and controlling the …

    adelaide Repository record

  18. MAPPING GENOMIC VARIANTS ASSOCIATED WITH FUNCTIONAL AND HEALTH TRAITS IN DAIRY CATTLE POPULATION

    PUNTURIERO, CHIARAUniversità degli Studi di Milano2026

    … seven dairy farms in the Lombardy region through Single Nucleotide Polymorphisms (SNP), Runs of Homozygosity (ROH) and Copy Number Variants (CNVs). The results revealed that intensive selection for milk yield, applied to Holstein cattle during the first decades of the 20th century, strongly shaped …

    milano Repository record

  19. Immungenetische Marker im Wandel der Zeit

    Pepperl, Jutta2012

    … Studie wurden daher die Allelfrequenzen von single nucleotide polymorphisms (SNP) der Interleukine IL6, IL10 und IL4 sowie der Rezeptoren IL4Ra, TLR2 und TLR4 untersucht. Ihre immungenetische Relevanz ist für moderne Bevölkerungen bereits durch Assoziationsstudien belegt. Zentraler Gegenstand …

    goettingen Repository record

  20. Mapping phenotypic traits in swine

    Wagner, Erin K.University of Illinois at Urbana-Champaign2011

    … for 137 microsatellite markers and 43,486 single-nucleotide polymorphisms (SNP). Two different analyses were performed to detect QTL in this population. For the first analysis, a linkage map consisting of 137 microsatellite markers was used to perform a regression interval analysis with …

    uiuc Repository record

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