Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Sin3A"”.
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Transcriptional functions of the corepressor Sin3A in skin
… regulators to EDC genes. Among these factors, Sin3A acts as a transcriptional co-repressor and was initially discovered via its direct interaction with Mxi1 and Mxd1, which are antagonists of the Myc family network. As such, I concentrated on the role of Sin3A as a potential opposing factor to …
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Role Of Maternal Sin3a In Reprogramming Gene Expression During Mouse Preimplantation Development
… this transcriptionally repressive state. Because SIN3A is essential for mouse development and is part of a HDAC1/2-containing complex, I investigated the role of maternal SIN3A in the development of the global transcriptionally repressive state that develops during the course of genome activation …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… skin, such as CEBPα, OVOL-1, KLF4, TCFAP2-γ and SIN3A, among others. I demonstrated that MYC recruits a specific set of tissue-specific transcription factors to the EDC, (e.g. KLF4 and OVOL-1) and thereby prevents binding of a different and distinct set of genomic regulators, (e.g. CEBPα , MXI1 …
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Analyzing The Interactions Of Kdm5/lid And Sin3 In Drosophila Melanogaster
… and developmental processes. Knockdown of both Sin3A and lid hinder cell proliferation in Drosophila cultured cells and developing flies. Knockdown of these genes also results in a curved wing phenotype implicating a role in wing development. Analysis of underlying gene expression changes upon …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
… two chromatin-modifying genes, Chd8 and Sin3a, as necessary for growth and survival of leukemic cells. While SIN3A is a well-characterized transcriptional co-repressor, the exact mechanism and relevance of CHD8 is less clear. Here we demonstrate that RNAi-mediated depletion of CHD8 in …
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UNDERSTANDING HEPATIC REV-ERBa INTERACTING PARTNERS AS IT PEAKS AND TROUGHS THROUGH THE CIRCADIAN DAY
… for follow up the discovery that the HDAC1/SIN3a complex interacts with REV-ERB. In chapter 4 we delve into the second novel finding that REV-ERB gets SUMOylated in a rhythmic manner. Finally we discovered that REV-ERBs play an important role in the regulation of SUMO3 expression in the …
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Analysing The Effects Of Loss Of Sin3 In Drosophila Melanogaster
<p><i>Sin3A</i> has been previously shown to be an essential gene for <i>Drosophila</i> viability and is implicated in the regulation of cell cycle. In this study, we show that SIN3 is not only required for embryonic viability but also for post-embryonic development. Genetic analysis suggests that …
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Before and after DUX4: deconstructing its web of silencers and defining its long-term impact on cellular processes
… identified D4Z4 silencers: SETDB1, ATF7IP, SIN3A/3B, and LRIF1. The reporter system also showed promise as a robust platform for further discovery of FSHD therapeutics and disease modifiers, with candidate therapeutic p38 pathway inhibitors showing increased repression in D4Z4-S5. Our …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… then activates DVL2/3, Rac1/Cdc42, JNK, and SIN3A signaling, as well as inhibits ROCK2 and β-catenin activity. For SNP rs9921222, homozygous TT has a higher expression of AXIN1 than homozygous CC. Molecular analysis shows that GATA4 favors binding at rs9921222 allele T to promote AXIN1 …
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Λειτουργική μελέτη του ρόλου νέων γονιδίων στην αύξηση των επιπέδων της εμβρυικής αιμοσφαιρίνης του ανθρώπου
… Στην παρούσα μελέτη, διερευνήθηκε ο ρόλος του SIN3A ως τροποποιητής της παραγωγής της εμβρυικής αιμοσφαιρίνης, καθώς είναι γνωστή η αλληλεπίδρασή του με το KLF10, γνωστό τροποποιητή της έκφρασης των γονιδίων της γ-σφαιρίνης. Αποδείχτηκε ότι μονονουκλεοτιδικοί πολυμορφισμοί που εντοπίζονται σε …
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Generation and Characterization of a Knock-In Allele of EKLF: Probing the in vivo Role of the Chromatin Remodeling Domain in Definitive Hematopoietic Cells
… H3 at the Fli-1 promoter; iii) recruitment of a Sin3A-containing corepressor complex to the <a></a>Fli-1 promoter. Taken together, my results suggest strongly that the unique D221EKLF domain is sufficient to modulate the chromatin-specific roles of EKLF at erythroid- and megakaryocytic-specific …