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Showing 1 to 20 of 20 for “"Simian Virus"”.
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Purification and Characterization of Simian Virus 40 Large T Antigen
Simian Virus 40 is a small DNA virus which can replicate normally following productive infection of permissive monkey cells, transform various cell lines of different species in tissure culture, and induce tumor formation following injection into newborn hamsters. Large T antigen is one of two …
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A Study of the Extraction and Dna Binding Properties of Simian Virus 40 Tumor Antigen
Made available in DSpace on 2014-12-14T04:27:46Z (GMT). No. of bitstreams: 1 7913620.pdf: 6964999 bytes, checksum: e1e92e09da3a24c6454bc7df96cf1643 (MD5) Previous issue date: 1978
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ORGANIZATION AND FUNCTION OF SIMIAN VIRUS 40 ORIGIN REGION SEQUENCES IN LATE GENE TRANSCRIPTION AND REPLICATION.
ORGANIZATION AND FUNCTION OF SIMIAN VIRUS 40 ORIGIN REGION SEQUENCES IN LATE GENE TRANSCRIPTION AND REPLICATION.
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A Role for Oligomerization in the Multifunctional Nature of the Simian Virus 40 Large T Antigen Protein (Tumor, Dna, Cell Transformation, Association)
Simian virus 40 (SV40) large T antigen protein plays a central role in the interaction of the virus with its host. It is required for both the growth of the virus in permissive hosts and in the transformation of non-permissive hosts to a tumorigenic phenotype. Biochemical studies reveal that large …
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Characterisation of the human α2(I) procollagen promoter-binding proteins
… had previously been transformed with either simian virus 40 (SVWI-38) or by γ-radiation (CT-1). The SVWI-38 fibroblasts do not produce any α2(I) collagen chains, whereas the CT-1 cell line produces normal type I collagen. Previous studies suggested that trans-acting factor(s) may be …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
… the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We found that systemic administration of the proinflammatory TH1 cytokine, IL-12, increased survival and tumor T cell infiltrate. The addition of costimulation through …
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Cloning of a putative human oncogenic virus, BK
Papova viruses are a group of non-enveloped icosahedral viruses which contain a double-stranded circular DNA genome in the supercoiled configuration. There are two subgroups, i.e., the papilloma and the polyoma viruses. The papilloma viruses are generally larger than the polyoma-viruses, having a …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… this question using: (1) spontaneously- and Simian virus 40 (SV40) large T antigen-immortalized oxoguanine glycosylase 1-null (Ogg1-/-) murine embryonic fibroblasts (MEFs); and, (2) human Ogg1 (hOgg1)- or formamidopyrimidine glycosylase (Fpg)-expressing human embryonic kidney (HEK) cells; …
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Epigenetic Patterns: Process-Driven Or Sequence-Driven?
… processes - here by using the well-suited model virus, Simian Virus 40. It has for some time now been agreed upon that epigenetic modifications of histone proteins not only exists, but play a crucial role in biological processes related to the availability or condensation of genetic material. …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… under the control of the mouse mammary tumor virus-long terminal repeat (pMMTV-IGF-I), early simian virus (pSV40-IGF-I), and herpes simplex thymidine kinase (pTK-IGF-I) promoters. Stably transfected clones were generated by cotransfection of clonal MAC-T cells with the IGF-I expression vectors …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… dissemination, and pathogenesis. The paramyxovirus simian virus 5 (SV5) is able to establish highly productive, persistent infections of cultured epithelial cells with minimal induction of host cell responses. In contrast, two SV5 mutants induce production of proinflammatory cytokines, type I …
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Respiratory infection with the paramyxovirus SV5 results in maturation and cytokine secretion in CD103- and CD103+ dendritic cell subsets.
… intranasal infection of BALB/c mice with paramyxovirus recombinant Simian Virus 5(rSV5-eGFP-p60) as a model to explore the behavior of these four DC subsets in vivo with regard to regulation of costimulatory molecules and cytokine secretion. We found that the number of mature DC, defined as CD80 …
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Single molecule fluorescence studies of replicative helicases
… helicase unwinding of double stranded (ds) DNA. Simian Virus (SV) 40 Large T-Antigen (L-tag) serves as a model replicative helicase for studying eukaryotic DNA replication. It belongs to the AAA+ family of helicases that bind to the origin of replication sites on the DNA and form higher order …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… mesothelioma, or MM). The DNA oncogenic virus Simian Virus 40 (SV40) has been shown to cooperate with environmental oncogenic fibers in the onset of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic malignancies and in the process of SV40-mediated …
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DNA synthesis and methylation in normal and transformed cells
… (WI-38) and its two transformed counterparts, a simian virus 40 (SV 40) transformed line (SVWI-38) and a y-irradiation transformed cell line (CT-1). HU was shown to enhance hypermethylation of pre-existing DNA strands in the normal cells, while ara-C and aphidicolin caused hypermethylation of …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… metal labels. The investigated peptides were the Simian Virus 40 nuclear localisation signal (NLS), the HIV transactivator of transcription (TAT) peptide and the small regulatory peptide, the neurotensin (NT). Metal conjugates of these bioactive peptides were successfully synthesized by solid …
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Regulation and patterning of cell differentiation and pluripotency
… Primary rat cardiomyocytes were transduced with simian virus 40 large T antigen (TAg), or with Bmi-1 followed by the human telomerase reverse transcriptase (hTERT) gene; the cells were expanded; and the transduced genes were removed by adenoviral vector expressing Cre recombinase. The TAg gene …