Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Silk Fibroin"”.
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NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT
… type I collagen protein with mechanical robust silk fibroin, and hemocompatible synthetic elastic polymer poly(glycerol-sebacate) (PGS). The central hypothesis of this project was: Electrospun grafts created from composites of type I collagen, silk fibroin, and PGS are stable, less thrombogenic …
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Template-directed Assembly of Silk in Advanced Materials for Food Security
… with structural biopolymers (e.g. silk proteins) to generate macroscopic yet nanostructured functional materials that can be interfaced with food and plants. Inspired by the way living systems regulate disorder to order transition of biomacromolecules to achieve complex materials, a …
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The Synthetic spider silk fibers spun from Pyriform Spidroin 2, a glue silk protein discovered in orb-weaving spider attachment discs
<p>Spider attachrnentdisc silk fibers are spun into a viscous liquid that rapidly solidifies, gluing dragline silk fibers to substrates for locomotion or web construction. Here we report the identification and artificial spinning of a novel attachment disc glue silk fibroin, Pyriform Spidroin 2 …
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Direct-write assembly of 3D microperiodic scaffolds for tissue engineering applications
… (pHEMA) in a photopolymerizable solution, (2) a silk fibroin ink, regenerated from Bombyx mori silkworm cocoons, that can be induced to change conformation in a coagulating reservoir, and (3) a hydroxyapatite (HA) particle-filled silk fibroin ink. By carefully controlling their rheological …
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Self-assembling silk hydrogels for mesenchymal stem cell and drug delivery
Silk fibroin has been commonly used as sutures and surgical meshes in humans. Additionally, silk fibroin had been used for a wide range of biomedical uses including as a coating for polymer scaffolds produced for tissue engineering and silk fibroin hydrogels containing silk nanoparticles have …
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FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING
… composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that …
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Hierarchical protein assemblies with biomedical applications
… fabrication of protein-based films. Regenerated silk fibroin, a natural block copolymer with the capacity to readily re-assemble into structures with attractive physical and chemical properties that are present in native silk, was used as a protein scaffold. The regenerated silk fibroin was …
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Příprava a charakterizace modifikovaných polysacharidových hydrogelů pro medicínské aplikace
… materiálů polysacharidu Gum Karaya a proteinu Silk Fibroin. Tento přístup umožňuje využití specifických vlastností každého jednotlivého materiálu v daném hydrogelovém systému a také studium jejich vzájemných interakcí. Při přípravě hydrogelu nebyla použita chemická síťující činidla, příprava …
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New water-soluble porphyrins for oxygen sensing in protein-based materials
… the proteins chosen as matrices for hydrogels (silk fibroin and collagen) was performed via N-hydroxysuccinimide chemistry. Oxygen response of the complexes synthesised was tested both in aqueous solution and supported on protein-based hydrogels. Most species showed oxygen-dependent fluorescence …
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Strategies to design and optimize natural polymers as biomaterial inks for musculoskeletal tissue engineering applications
… Most of the research was carried out on silk fibroin, a protein commonly used for tissue engineering scaffold fabrication owing to its promising physical and biological properties, although it lacks the rheological properties required for extrusion-based bioprinting. Different approaches …
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Synthesis and microfabrication of elastomeric biomaterials for advanced tissue engineering scaffolds
… of next-generation microfluidic scaffolds using silk fibroin from the Bombyx mori as a bulk material. The need to combine the advantages of both natural proteins and synthetic polyesters motivated the synthesis and characterization of a new class of biodegradable elastomers termed …
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Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
… was the extracellular matrix. Two formats of silk fibroin-hydrogel and porous scaffolds - were examined for their potential as a supporting material for creating cartilage tissue constructs. The composite silk made from nano-fibers and hydrogel - a structure resembling the collagen network and …
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Precision Delivery of Multi-Scale Payloads to Tissue-Specific Targets in Plants
… plants. Specifically, the thesis designs a novel silk-based biomaterial and fabricates a microneedle-like device capable of delivering a variety of payloads ranging from small molecules to large proteins into specific loci of various plant tissues. Precisely sampling plant sap is also demonstrated …
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Nanoscale investigation of silk proteins using near-field optics
… in structural biopolymers, specifically silk protein, as functional materials. The exceptional mechanical properties and the bio-compatibility of silk has enabled wide range of applications from biomedical devices, optics, electronics, to transient implants. Understanding the mechanisms …
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Design of Engineered Biomaterial Architectures Through Natural Silk Proteins
Silk proteins have provided a source of unique and versatile building blocks in the fabrication of biomedical devices for addressing a range of applications. Critical to advancing this field is the ability to establish an understanding of these proteins in their native and engineered states as well …
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Bone Tissue Engineering: structures and strategies for functional scaffold design and evaluation
… by cells. We used two polymers, naturally (silk fibroin) or synthetically (poly-d,l-lactic acid) derived, and we modulated scaffold geometry (random vs ordered pore distribution), pore size and chemical composition, combining spongy and fibrous structures. The scaffolds were indeed …
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Controlled self-assembly of natural proteins into hierarchically structured functional materials
… the molecular self-assembly mechanism of silk fibroin, a natural protein used by silkworms to generate fibres. Through applying kinetic analysis, I demonstrated that the self-assembly process is dominated by a secondary process in which the formation of new fibrils is catalysed by the …
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Microfluidic formation of hierarchical micro and nano emulsions for biomedical applications
… and lack of cellular toxicity is silk-derived proteins. Regenerated silk fibroin (RSF) in particular, retains most of the properties of native silk but is readily available through scalable processes. This natural block copolymer has the propensity to self-assemble into a fibrillar …
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Understand The Structure-Water-Responsive Relationship by Engineering Silk Materials
… by engineering <em>Bombyx (B.) mori</em> silkworm silk protein. First, by increasing the silk’s mechanical stiffness as a result of increased silk II structures (β-sheet rich domains) or adding stiff silica nanoparticles, <em>B. mori</em> silk’s WR actuation energy density was dramatically …
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TISSUE ENGINEERING CELLULARIZED SILK-BASED LIGAMENT ANALOGUES
The resurgence, and eventual rise to prominence in the field of tissue engineering, that electrospinning has experienced over the last decade speaks to the simplicity and adaptability of the process. Electrospinning has been used for the fabrication of tissue engineering scaffolds intended for use …
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