Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Silicon photonic microring resonators"”.
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Particle-enhanced biomolecule detection using silicon photonic microring resonators
… has developed a detection platform based on silicon photonic microring resonators which is capable of making sensitive measurements of proteins, as well as other biomolecules, in complex matrices. The following chapters present the work I have completed towards the development of …
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Surface modification of silicon photonic microring resonators for chemical sensing
Silicon photonic microring resonators have emerged as a promising technology for the sensitive detection of biological macromolecules, including proteins and nucleic acids. These bulk property detectors rely on the changes in the effective refractive index of the sensing region, eliminating the …
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Silicon photonic microring resonators for the development of cancer protein biomarker assays
… dissertation presents the development of silicon photonic microring resonator technology in the Ryan Bailey research laboratory towards multiplexed cancer protein biomarker measurements. Microring resonator sensing technology relies upon changes in refractive index that induce a resonance …
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Multiplexed protein biomarker analysis on silicon photonic microring resonators: translation towards clinical diagnostics
… thesis were developed on a platform based on silicon photonic microring resonator technology. This sensing technology has high potential for clinical diagnostics utility, as sensor chips of this platform can be cheaply manufactured through a highly scalable process. Moreover, continuous …
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Advances in molecular-based diagnostics and biomolecular interaction screening using silicon photonic microring resonators
… biomarker panels meaningful predictive power. Silicon photonic microring resonators are a promising class of sensor well suited to biomarker quantitation due to their sensitivity, scalability and flexibility, enabling quantitative multiplexed analysis. Their sensing modality arises from …
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Expanding the toolbox for precision medicine with silicon photonic microring resonators and microfluidic technologies
… diagnostics. Most of the following work uses microring resonator arrays as the detection platform, a versatile silicon photonic biosensing technology. Chapter 1 reviews the applications of optical resonators in analytical chemistry. Microring resonators arrays are a class of whispering gallery …
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Multiplexed immunoassay development for precision medicine diagnostics and protein characterization using silicon photonic microring resonators
… developing robust multiplexed immunoassays with silicon photonic microring resonator arrays. Using this basic protocol for assay development, Chapters 3 and 4 describe two distinct approaches toward diagnosing and monitoring infectious disease related states. Chapter 3 focuses on designing a …
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Multiplex analysis of protein-lipid and protein-membrane protein interactions utilizing silicon photonic microring resonators
… accomplish this, nanodiscs were integrated with silicon photonic microring resonators. Nanodiscs are easy to assemble, nanometer scale lipid bilayer discs which offer a high degree of control over lipid and membrane composition. Each nanodisc is held together by two membrane scaffold proteins …
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Improving multiplexed RNA detection assays by interfacing enzymatic amplification strategies with silicon photonic microring resonators
… that combing enzymatic processing steps with silicon photonic microring resonators, a technology pioneered by the Bailey Research Laboratory. While other efforts in lab have been geared to other classes of biomolecules, the developed assays discussed in this dissertation are designed to …
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The development of new sensing methodologies for nucleic acids using arrays of silicon photonic microring resonators
… developed a sensing platform based on arrays of silicon photonic microring resonators that is highly amenable for the quantitative, multiplexed detection of nucleic acids, in particular, miRNAs. We begin by demonstrating a label-free method for the quantitative, multiplexed detection of miRNAs. …
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Application of silicon photonic microring resonators to the study of surface bioconjugation and protein capture agent binding kinetics
… To address some of these issues, we employ silicon photonic microring resonators, an emerging surface-sensitive analysis method that our group has recently utilized for monitoring biomolecular binding and detection in an array-based, label-free biosensor format. First, aniline-catalyzed …
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Thermal detection in the long wave infrared and very long wave infrared regions
… certain applications. The advancement of microphotonic resonators has brought interest of their use as detection devices due to their small size and high quality factors. Implementing silicon photonic microring resonators as a means of a thermal detector gives rise to higher speed and …
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Synthesis and kinetic processes in designed polymers
… and concentration, and biocompatibility. Silicon photonic microring resonators have emerged as a promising technology for the sensitive detection of toxic and regulated substances. By functionalizing the surface of silicon photonic microring resonators with polymer brushes, we find that …
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Development of silicon photonic microring resonator biosensors for multiplexed cytokine assays and in vitro diagnostics
… translational biosensing technology based on silicon photonics and developed in the chemistry research laboratory of Ryan C. Bailey. Silicon photonic microring resonators, a class of high-Q optical sensors, represent a promising platform for rapid, multiparameter in vitro measurements. The …