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Showing 1 to 4 of 4 for “"Silanolates"”.
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Palladium-Catalyzed Cross-Coupling Reactions of Heteroaryldimethylsilanols: New Methods for the Formation of Substituted Heterocycles Using Preformed and Isolated Silanolates
A procedure for the preparation of multi-substituted indoles using the Larock indole synthesis was developed. The heteroannulation reaction can be used to prepare 2,3-disubstituted indoles in good yields. The identification of a t-butoxysilyl ether as the masked silanol further expanded the scope …
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Palladium catalyzed cross-coupling reactions of allyl- and vinylsilanes
… cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that undergoing an activated pathway significantly lowers the selectivity of the reaction. A …
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I. Mechanistic significance of the Si-O-Pd linkage in the cross-coupling of organosilanolates; II. Applications of the water-gas shift reaction in organic synthesis
… cross-coupling reaction of alkenyl- and arylsilanolates. The combination of reaction kinetics (both stoichiometric and catalytic), solution and solid state characterization of arylpalladium(II) organosilanolate complexes, and computational analysis, enabled the formulation of a detailed …
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1. Reinvestigation of a catalytic, enantioselective alkene dibromination and chlorohydroxylation, 2. Double cross-coupling reactions of siloxaborolates, 3. The enantioselective synthesis of 3-substituted morpholines using computer-guided catalyst design
In Chapter 1, attempts to reproduce eight, putative, enantioselective dibromination and chlorohydroxylation reactions from oft-cited literature studies are described. The reactions were performed with full fidelity to the original report wherever possible. Analysis of the enantiomeric composition …