Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Significant activity"”.
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The Synthesis and properties of functionalised polymers
… relative to quartz. However no materials of significant activity were produced. In an attempt to produce polymers that might subsequently be functionalised the polymerisation of 1,2-methylenedioxybenzene and 1,4-benzodioxane was investigated.
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In Vitro Selection and Characterization of Highly Selective Metal -Dependent DNAzymes With Potential Biosensor Applications
… an improved Pb2+ biosensor that does not display significant activity with contaminating metal ions.
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An investigation into nucleic acid binding compounds
… Whilst a range of our compounds display significant activity against Gram positive bacteria, very few have significant activity against Gram negative species. In order to investigate this, a series of compounds has been synthesised, based on known Gram negative active compounds, and these …
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A Phenomenological Study of V.A.-Affiliated Nonprofit Leaders: Experiences Navigating the Blurred Lines at the Boundary Between the Public and Private Sectors
… of explicitly public missions, but through significant activity occurring at the boundary between—and including areas spanning both—the public and private sectors. This includes the network of more than 80 congressionally authorized, state-chartered, research and education nonprofit …
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The antioxidant activity of the extract of Pangium edule Reinw. (Keluak) seed in cooked ground turkey
… Keluak extract concentrations (K200 and K400) significantly reduced lipid oxidation and exhibited significant activity comparable to BHT at 200ppm.
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Deformation and Its Effect on Recrystallization in Magnesium Alloy AZ31
… X-ray diffraction (XRD). The results revealed significant activity of basal and non-basal slip as well as twinning. The twins were mainly of the contraction and double-twin (contraction-extension) types. In addition to the micron scale (1-5μm) twins observed on EBSD patterns, nano-scale twins …
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Behavioral and Functional Brain Correlates of Developmental Coordination Disorder: A Case-Control Study
… metrics of fine motor control and showed significant activity (p < 0.001) in the occipital and frontal gyri, with less robust activations (p < 0.01) in the left motor cortex and left inferior parietal lobe while performing the tracking task. These results imply that the DCD subject relied …
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Between Wildness and Art: Ecology and Agency in Victorian Literature
… attentiveness to non-human nature, but without significant activity on its behalf. This dissertation goes on to argue that the idea of human responsibility for non-human degradation, though uncommon in the Victorian period, can be found in several key texts. George Eliot's character, Adam Bede, …
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Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds
… role in DNA damage repair, and lack of PARG activity after DNA damage prevents repair and causes a build-up of toxic PAR chains. As such, PARG inhibitors have been pursued for decades as anticancer compounds. In this document, the structure-activity relationship of the rhodanine-based PARG …
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Investigating default mode network activation during external task switches and movie watching
… internally-directed thought, shows increased activity during demanding external task switches between cognitive domains, as reported by Crittenden et al. (2015) and Smith et al. (2018), which challenges prevailing views of DMN function. What might the role of DMN be in response to external …
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Pharmacognostic study of 5 medicinal plant species from Western Cape Province (South Africa) for anti-tubercular activity
… area and investigated for antimycobacterial activity following report of their therapeutic use in traditional medicine to treat infectious diseases such as tuberculosis. A bioassay guided fractionation of the acetone/water (4:1) crude extracts of O. capensis (leaves) and T. alliacea …
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Sodium entry pathways in isolated goldfish hair cells
… total steady-state Na⁺ entry. Consistent with a significant component via the Na⁺/Ca²⁺ exchanger, nifedipine, a blocker of L-type calcium channels, also reduced the Na⁺ entry rate. Since the Na⁺/H⁺ exchanger in goldfish hair cells, in contrast to many other cell types, displayed significant …
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Screening, isolation and characterization of laccase enzymes from Namibian Termitomyces schimperi and Kalaharituber pfeilii
… pfeilii fruiting bodies for laccase enzymatic activity using α-naphtnol and 2, 2-azino-bis 3-ethylbenzthiazoline-6-sulphonic acid (ABTS). A clone of T. schimperi was also grown in the laboratory under controlled conditions. A purification protocol of laccase from K. pfeilii consisted of …
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Phytochemical and Antimicrobial Studies on Selected Medicinal Plants from The Iraqi Flora: Citrus grandis, Citrus sinensis and Ruta chalepensis
… to study the phytochemicals and antimicrobial activity of these plants. The n-hexane, DCM and MeOH extracts of all plants and plant parts, obtained from successive Soxhlet extraction, were assessed for their antimicrobial proprieties using the microtitre resazurin assay involving two …
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Phosphofructokinases from extremely thermophilic microorganisms
… of interest with respect to the evolution of PFK activity and of the Embden-Meyerhof (EM) pathway. To gain additional insight into the understanding of this key enzyme in the central metabolism within the three domains of life, PFKs with different phosphoryl donor specificities were studied from …
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Synthesis and Evaluation of a Novel Series of β-Diketones and Related Compounds as Anticancer Agents
… been synthesised, characterised, and tested for activity on 6 different cancer cell lines. All the β-diketones synthesised appeared as the enolic tautomer, with chemical shifts ranging between 16.25 ppm – 17.15 ppm. The synthesised compounds were tested on lung adenocarcinoma (A549), human bone …
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Characterization of Novel Urethanases and a Commercial Cutinase for the Degradation of Polyurethane
… to assay partially purified WprA demonstrated significant activity on substrates of interest. Specifically, opaque Impranil dispersions were cleared by treatment with WprA, strongly suggesting that this enzyme can hydrolyze polyester PU. To further this work, an on-plate screening method was …
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HORMONE EPIMERS REGULATE ER STRESS AND CORE REGULATORY GENES: NETWORK ANALYSIS WITH APPLICATIONS TO GLIOMA AND CHRONIC PRESSURE ULCERS
<p>DHEA has been determined to have medically significant activity and is the parent compound to the more active metabolites; 17α-AED, 17β-AED and 17β-AET, which exhibit strong biological activity that has been attributed to androgenic, estrogenic or anti-glucocorticoid activity in vivo and in …
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Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
… cessation drug Cyt at α4β2 nAChR but had no significant activity at α7 subtype. Molecular docking in combination with functional assays showed that differences in residues in the complementary side of the agonist site do not account for the selectivity of the C(10) Cyt derivatives. However, …
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Intervención intercultural mediante actividades significativas personales y colectivas
El objetivo general de esta tesis es analizar el impacto del desarrollo de actividades con propósito en la salud y bienestar desde una perspectiva intercultural en el desarrollo de programas comunitarios. Para ello, se diseña un estudio desarrollado en Marruecos y Perú. En el país africano, por un …
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