Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Signatures of selection"”.
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Signatures of selection in the red fox (Vulpes vulpes) in Europe using genotype-by-sequencing
… on variations in individuals via the mechanisms of natural selection, genetic drift, and gene flow. Using genomic sequencing methods such as genotype-by-sequencing (GBS) to detect single nucleotide polymorphisms (SNPs) can lead to a better understanding of a species evolutionary history and …
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Conservation management in the age of genomics: Assessing translocation success and signatures of selection in a conservation icon, the greater prairie-chicken
… published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Evolution, Evolvability, Expression and Engineering
… and (b) Expression. In the first part of this thesis, I present a framework for understanding and engineering biological sequences, and solving sequence→function problems by building ‘Complete Fitness Landscapes’ in sequence space. This framework for measuring, modelling and designing …
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Natural Selection on S-Linked Genes in Turnera (Passifloracease)
Investigations of the evolutionary dynamics exhibited by S-linked loci have the potential to provide evidence concerning the particular genes that determine the expression of distyly in flowering plants. Several approaches were adopted to explore the signatures of selection on S-linked genes in …
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Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population
Multiple independent transfers of simian immunodeficiency virus (SIV) strains from chimpanzees to human populations produced the current HIV-1 pandemic. We hypothesized that Central African human populations may have been exposed to SIV prior to the current pandemic, and that previous local …
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Annotation of Non-Model Species’ Genomes
… unprecedented examination and characterization of the genetic make-up of both model and non-model species, which has led to a surge in the use of genomics in fields which were previously considered unfeasible. These advances have greatly expanded the realm of possibilities in the fields of …
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Fine Mapping and Evolution of a QTL Region on Cattle Chromosome 3
Using genotypes obtained from the offspring of three half sib families, paternal and maternal haplotypes of the offspring were reconstructed in addition to the six sire haplotypes. A 9.7 Mbp haplotype block likely to be identical by descent was identified in sires, S1 and S2. This shared haplotype …
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Assessing genomic variation in the hopbush, Dodonaea viscosa, to investigate micro-evolution and adaptation
In this thesis I use a range of genomic tools in order to investigate aspects of the evolutionary history of the hopbush, Dodonaea viscosa (L.) Jacq. (hopbush). Understanding the past evolutionary processes that have led to the distribution and adaptation of contemporary populations can help to …
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Genome Analysis of the Ashanti Dwarf pig of Ghana
The Ashanti Dwarf pig, an indigenous pig breed of Ghana, like other local pigs in Africa is mainly raised under extensive production farming systems with little financial inputs by resource poor farmers who are mostly women to provide them with food, employment and an income. These indigenous pigs …
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Genomics and ecology of rapid adaptation: the expansion and evolution of the invasive common myna (<i>Acridotheres tristis</i>) and common starling (<i>Sturnus vulgaris</i>) in New Zealand
Invasive species are one of the main drivers of biodiversity loss and information on their ecology and genetics can provide useful insights for their management. Invasive species, while harmful to native ecosystems, constitute “natural experiments” and offer uniquely replicated model systems to …
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Analysis of within-host evolution of Plasmodium Falciparum during treatment
… Plasmodium falciparum parasite genomes and leave signatures of selection. The evolutionary basis of drug resistant malaria in endemic and epidemic settings continues to remain an ongoing scientific priority whose solution carries a significant effect on treatment outcomes. To understand the …
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Adaptation and hybridization in Helicoverpa crop pests
… food security and biodiversity. The process of biological invasion often results in secondary contact between closely related taxa, producing ‘experiments in evolution’. Evolutionary genetics can be used to study invasive species and inform their management. In this thesis I focus on noctuid …
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Transcriptomic study of evolution and gene expression in diploid and allotetraploid glycine subgenus glycine
… subgenus Soja and subgenus Glycine. One of the member species of subgenus Soja, soybean (Glycine max) is an important crop plant that has been extensively studied. Unlike soybean, the perennial wild relatives in subgenus Glycine are less well known even though they possess both an …
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Understanding Osmoregulation and Immunity in Heteromyid Rodents Through Insights Gained from RNA-Seq
<p>Understanding the genetic basis of adaptation is one of the central questions of evolutionary genetics. In the face of selective pressure, individuals with adaptive phenotypes survive and pass on their beneficial alleles that conferred this fitness advantage. Over sufficient time scales and …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
… recognition. Within this region, only a subset of MHC class I (MHC-I) genes encodes classical molecules that present peptides to CD8+ T cells. These molecules exhibit extraordinary genetic polymorphism, particularly in their peptide- binding domains, enabling them to bind a diverse array of …
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Dichlorodiphenyltricholorethane (DDT) resistance mechanisms in Drosophila melanogaster and applications for the cowpea pest Clavigralla tomentosicollis
Control of insects by insecticides has led to resistance in both medical and agricultural pests as well as health and environmental concerns, and improved insect pest management (IPM) programs are necessary. The arrival of next-generation sequencing (NGS) and lowered sequencing costs provides the …