Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"Signalling mechanism"”.
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The monetary theory of production of John Maynard Keynes: Toward a unification of money and value theory
… role that expected and actual profits play as a signalling mechanism in a monetary-market economy. The final main chapter brings together the models developed in both the Treatise on Money and the General Theory in order to highlight the monetary theory of production, the role that money plays in …
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Mutant analysis of luminescence and autoinduction in a marine bacterium
… regulate light emission using a cell-to-cell signalling mechanism called autoinduction. The latter is mediated by a signal molecule called the "autoinducer". The mechanistic bases of both luminescence and autoinduction are well known in V. fischeri, but this knowledge is mostly derived from …
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Signalling Molecule Production by Escherichia coli and Campylobacter jejuni
… (QS) is a density-dependent gene regulation signalling mechanism utilized by bacteria to enable the simultaneous expression of bacterial phenotypes in a given population. Several QS mechanisms and different classes of signalling molecules, including acyl-homoserine lactones (AHLs), have now …
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Quantifying passive drug transport across lipid membranes
… crisis. One of the most common drug resistance mechanisms involves bacteria adapting to reduce intracellular drug accumulation. To understand these resistance mechanisms, one needs quantitative information about the membrane permeability of drugs. In this Thesis, we develop a novel optofluidic …
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Molecular characterization of motility genes in Bacillus subtilis
… suggest that a guanosine nucleotide-dependent signalling mechanism is required, in some capacity, to generate a B. subtilis flagellum. A further analysis of the che/fla operon uncovered flhA, a flagellar gene that encodes for a putative signal-transducing receptor as suggested through strong …
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Open network control : towards an integrated telecommunications future
… a number of projects looking at open control mechanisms, using a combination of low-level interfaces onto network devices and the use of middleware technology to provide the control interaction between these devices. In the thesis, the need is argued for a generic level of network control that …
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Molecular insights into signalling mechanisms within TGF-β superfamily
… superfamily includes receptors, extracellular signalling molecules, their inhibitors and intracellular downstream signalling components. Members of the superfamily are present in all metazoans, expressed in all cells of the body and they are involved in embryonic development, adult tissue …
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Role of DARPP-32 in Breast Cancer Cell Signalling and Migration
… that CREB plays a functional role in this signalling mechanism. Finally, we found that phospho-DARPP-32 inhibited the activity of the focal adhesion kinase (FAK) in MCF-7 breast cancer cells, and that MCF-7 cells expressing phospho-DARPP-32 displayed less filopodia formation. These results …
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Alpha v beta 5 and related receptors in human B lymphocyte development
… cells, presumably via the αvβ5, results in signalling through PI3K and subsequent phosphorylation of Akt. The growth of SMS-SB cells observed following stimulation with peptides containing the RKC motif was abrogated by the PI3K inhibitor LY294002 and western blotting revealed that …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… of EP3Re in human brain, to determine its signalling mechanism and explore whether any meaningful interaction between EP3Re, tau and its pathology exists. We use immunohistochemistry, proximity ligation assays and electron microscopy to map out the distribution of EP3Re in the human brain …
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Mitochondrial metabolism and CNS myelination
… oxygen species (ROS) as an important and novel signalling mechanism, with potential therapeutic application. It was found that 8) modulating ROS feedbacks back to the mitochondria, upregulating biogenesis. Most importantly, inducing mitochondrial activity increases the number and the length of …
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Artificial Transmembrane Signalling
… proteins play a vital role in these signalling pathways. A large number of examples of synthetic membrane channels and transporters have been reported in the past four decades. However, signal transduction without mass transfer is considerably more challenging. In this dissertation, …
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Structural insights into the GABAA receptor gating cycle
… is a crucial requirement for accurate synaptic signalling. Such fast conformational transitions, however, have proven impervious to investigation via conventional structural biology methods. Moreover, GABA<sub>A</sub> receptors operate in cellular membranes with diverse lipid compositions and …
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Investigating WNT signalling in the lung
… As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of the …
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Quorum sensing for improved production of industrially useful products from filamentous fungi
… of low molecular weight, diffusible chemical signalling molecules, known as quorum sensing molecules (QSM) in the extracellular milieu. When the concentrations of the QSMs reach a critical threshold corresponding to a particular cell density, they bind to a receptor enabling them to function …
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Elucidating the role of Gremlin1 in colorectal cancer
… an in-depth understanding into the molecular mechanisms by which GREM1 regulates these processes remains elusive. <br/><br/>Using a series of in silico and in situ methodologies, we identified that GREM1 expression is significantly higher in the colorectal cancer consensus molecular subtype-4 …
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Polarity establishment and signalling mechanisms controlling patterning in Hibiscus Trionum petals
… of the adaxial petal epidermis. However, the mechanisms controlling cell differentiation across the petal surface to form such an elaborate and robust pattern are unclear. Positional information is required for cells to be able to differentiate correctly along the proximo-distal (PD) axis of …
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Acoustic manipulation by brood-parasitic honeyguide
… by host parents. However, the acoustic mechanisms facilitating this phenomenon remained unknown. In this dissertation, I first test whether greater and lesser honeyguides mimic the begging calls of their respective hosts and quantify the accuracy of acoustic mimicry. I then test the …
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Propuesta y evaluación del protocolo SIP para el soporte de señalización en la red de acceso radio de sistemas UMTS
… and it is debating the use of SIP as the signalling mechanism between ATM UTRAN nodes and IP UTRAN nodes. This thesis proposes an altemative to support the signalling functions in the UMTS Terrestrial Radio Access Network (UTRAN). In concrete, it proposes a signalling schema with SIP …
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Cell Fate Decisions in the Developing Lung
… space, and decreased branching. To explore the mechanism of glucocorticoid activity in human lungs, organoids were derived from late-stage (17 post-conception weeks or older) embryos and treated with a variety of glucocorticoids or other maturation reagents. These showed varying levels of …
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