Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Signalling inhibition"”.
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TGFβ signalling in microglia and the impact of microglia-specific Smad4 deletion
… the role of transforming growth factor-β (TGFβ) signalling in microglia and the regulation of Smad4-mediated microglial functions, and their subsequent impact on central nervous system (CNS) homeostasis, neurodevelopment, and neuroinflammation. The study comprehensively describes the TGFβ …
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Studies on the POLARIS gene of Arabidopsis
… PLS acts as a negative regulator of ethylene signalling. The pls mutant has enhanced ethylene signalling, which is the key determinant of its short root phenotype and results in a ‘triple response’ phenotype when seedlings are grown in the dark in air. The defects can be rescued by inhibition …
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Investigations of collective cell movement during gastrulation in the chick embryo
… was not mediated by tyrosine kinase (RTK) signalling. Inhibition of major classes of RTKs expressed in chicken gastrulation failed to abolish chemotaxis, however the serum response was sensitive to pertussis toxin (PTX), a potent inhibitor of Gai/o signalling. Uniform FBS concentration …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… stem cells (hESCs) rely on FGF and TGFβ signalling for self-renewal, and occupy a developmentally advanced state of pluripotency comparable to mouse EpiSCs. Recent reports demonstrate that a naïve state of human pluripotency can be consistently derived either through transient histone …
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Exploration of novel activin A antibodies
… the regulatory pro-domain, which modulates the signalling activity of the mature growth factor domain. Through interactions with extracellular matrix components, pro-domains facilitate growth factor storage, localisation, and activation through mechanisms driven by distinct structural …
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Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets
… vascular smooth muscle function and highlights inhibition of SPAK function as a promising anti-hypertensive strategy with multiple sites of action. To address these possibilities the work aimed to phenotype: (1) heterozygous CUL3$^{WT/\Delta403-459}$ mice to investigate a possible vascular …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… x Rosa mice) to determine the effects of Gli1 inhibition/ablation on fibrovascular lesion development. Cell survival assays of retinal pigment epithelial and microvascular endothelial cells in the presence of TGFβ2 together with/without Gli1 inhibitor GANT61 were utilised to interrogate the …
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In-vivo and in-vitro study of mechanism of action of 4 hydroxyisoleucine as an amino acid derived from fenugreek seed with anti-diabetic and properties
… insulin-responsive and dependent on the insulin signalling pathway for glucose uptake. Use of the model provides the opportunity to study the mechanisms of action of both 4-hydroxyisoleucine and isoleucine independently. We adopted a unique approach using inhibitors to target suggested pathway …
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Developing Chemical Tools for the Inhibition of Activin A Signalling
… which are post translationally cleaved. Upon signalling the pro-domain dissociates from the mature growth factor. Signalling in this family requires a type I and a type II receptor. Though there are over thirty growth factors, there are only seven type I and five type II receptors resulting in …