Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Signaling transduction."”.
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Nuclear Translocation of Met Via Internet Mechanism
… RTKs are traditionally known for their roles in signaling transduction from the cell surface, recent studies have provided evidence demonstrating that most of RTKs can translocate into nucleus to regulate cellular processes in response to both ligand and stress stimulation. Oxidative stress is a …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also associated with a …
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Photosensing with LOV: Molecular Insights into the Shared Mechanism of Light-Regulated Kinase Signaling between Plant Phototropins and Bacterial Two-Component Systems
… of Light–Oxygen–Voltage (LOV) domain mediated signaling transduction pathways, my graduate research focused on characterizing the role of LOV domains in kinase signaling and the mechanism of signal propagation from LOV domains to a diverse set of downstream effectors. I started from the studies …
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Understanding the Molecular Level Interactions of Cancer Inhibitor Imatinib with Human Fibroblast Growth Factor-1
… to determine probability of inhibition of hFGF-1 signaling transduction by imatinib. Imatinib, a 2-phenyl amino pyrimidine derivative is a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to the intracellular pocket located within tyrosine kinases and inhibit the downstream …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… chemoresistance. After years of effort, the signaling pathways involved in TNBC chemoresistance are gradually revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its overactivation renders …
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Synthesis, design and characterization of a distributed feedback grating based non-linear optical chemosensor
… regimes necessitates the development of new signaling transduction strategies. There are just too few sensing active sites on the micro- and nano-patterned structures to permit species detection, resulting in the compromise of device sensitivity and performance. This thesis work addresses …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… skeletal muscle and liver by inhibiting insulin signaling transduction. Interleukin-1 receptor-associated kinase-1 (IRAK-1) is a serine/threonine kinase functioning in Toll-like Receptor signaling pathways, and plays an important role in inflammation and immune response. In our studies, we …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
… (TICs) populations has been studied, but the signaling transduction mechanisms that regulate EZH2 in these TIC populations is yet to be elucidated. Phosphorylation of EZH2 by cyclin dependent kinases (CDK) has been reported to control EZH2 epigenetic function and thus consequently control …
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Protein spatiotemporal dynamics in gene regulation and disease pathology
… condensates in normal cells to perform metabolic signaling transduction. In insulin-resistant cells which could occur in chronic diseases such as type 2 diabetes (T2D), IR signaling is dysregulated, associated with diminished IR condensate dynamics of assembly and disassembly (Dall’Agnese et al., …
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Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
… angiogenesis. Previous studies have shown that signaling through IGF-IR leads to the vi activation of multiple signaling transduction pathways mediated by the receptor-associated tyrosine kinase domain. These pathways include PI3K/Akt, MAP kinase, and Jak/Stat. In the present study, we tested …
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Regulation of The Escrt Function of Alix
… phosphorylated ERK1/2, which is the downstream signaling of activated EGFR, I showed that CHMP4-bound ALIX dimer plays an essential role in MVB sorting and silencing of activated EGFR. However, MVB sorting of activated EGFR is not required for its degradation. My studies thus identify ALIX as an …
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Mechanistic insight into the role of dietary fibers and short chain fatty acids in the regulation of metabolism and inflammation in the pig
… roles in the regulation of metabolism and signaling transduction pathways. Our studies present a novel paradigm for the effects of dietary fiber and related fermentation products and show that these are capable of improving growth performance and gut health as well as improving insulin …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… no effect on EGF activation of the ERK or AKT signaling pathways, it abolished EGF-mediated immediate early gene expression, suggesting EGF stimulated calcium efflux and signaling transduction are two independent pathways and are both essential for EGF regulated gene expression. Knockdown of …
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A novel computational method for predicting tissue-specific disease-associated signaling pathways in human utilizing Caenorhabditis elegans reference data.
Signal transduction is a hot topic as molecular biology grows because it directly relates to cellular processes, supporting function of the organism as a whole. A dysfunctional signal transduction will cause uncoordinated cellular behaviors. For humans, these uncoordinated cellular behaviors will …
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The effects of Low α-Linolenic fatty acid Soybean Oil and Mid Oleic acid Soybean Oil on the growth of Her-2/neu and Fatty acid synthase over-expressing human breast cancer (SK-Br3) cells
… involved in growth factor mediated signal transduction pathway, specifically Her-2/neu PI 3-kinase (phophoinositide 3- kinase)-FAS signal transduction pathway. In vitro study demonstrated that all the tested oils at 0-2 μl/ml level have cytotoxic effects. LLMOSO had less cytotoxic effects …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… combination therapy through 6 myogenic signal transduction pathways including WNT, HH, BMP, Adenyl Cyclase, P38/MAPK and PI3K. While it is not feasible to target each of these signal transduction pathways simultaneously in RMS, we discovered that they require the HSP90 chaperone to sustain the …
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The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM
… resistance. Recently, defects in the insulin-signaling cascade have been implicated in the pathogenesis of insulin resistance. Also obesity is a metabolic disease and insulin resistance is a pathogenesis of obesity. So obesity is correlated with insulin resistance. To study insulin signaling …