Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 804 for “"Signaling pathway"”.
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Studies of the Hippo Signaling Pathway
… have identified the Hpo tumor suppressor pathway as a crucial mechanism that controls tissue growth by inhibiting cell growth, proliferation and survival. Deregulation of the Hpo pathway has been implicated in various human cancers. Central to the Hpo pathway is a kinase cassette …
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Studies of Smoothened in Hedgehog Signaling Pathway
… vertebrates and invertebrates. Malfunction of Hh signaling has been implicated in numerous human disorders. As the Hh signal transducer, the seven-transmembrane protein Smoothened (Smo) is highly regulated. It is still a mystery how Smo transduces graded Hh signal to downstream components. …
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Evolutionary analysis of Suidae TLR signaling pathway
… molecules and engage downstream intracellular signaling cascades eventually leading to an innate immune response. Thus, the TLR signaling pathway is under selective pressure from pathogens and is essential for host survival. The family Suidae (domestic pigs and their wild relatives) has …
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Characterization of theWound-Induced Signaling Pathway In Tomato
… insects initiates the systemin-mediated wound signaling pathway. Systemin is an 18 amino acid peptide that binds to the systemin receptor and initiates an intracellular signaling pathway that results in the accumulation of defense compounds in the leaves of the plant. The systemin signaling …
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Molecular mechanisms underlying Juvenile hormone (JH) signaling pathway
… the role of protein kinase C (PKC) in JH signaling in adult mosquitoes and to find the direct target genes of Krüppel homolog 1 (Kr-h1), a zinc finger transcription factor encoded by a JH early response gene. We discovered that PKC is an essential component of a membrane-initiated JH …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… fundamentally attributable to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying …
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GPCR to Channel Communication in a Membrane Signaling Pathway
… the heart rate. In addition to the Gαs and Gαi pathways, there is also the Gαq signaling pathway. In this pathway, activation of Gq-coupled GPCRs can lead to the activation of phospholipase Cβ (PLCβ). This enzyme can then hydrolyze phosphatidylinositol 4,5- bisphosphate (PI(4,5)P<sub>2</sub>) …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… the expression and the role of Sonic hedgehog signaling pathway in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient mice do not …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… the steps in the oxysterol-induced apoptosis signaling pathway in murine macrophages subsequent to the liberation of AA. To elucidate this mechanism, two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol (25-OHC), were used to induce apoptosis in murine macrophage cell lines (P388D1, and …
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The Hippo Signaling Pathway in Organ Size Control and Regeneraton
The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. Our lab has previously demonstrated that Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) …
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Elucidating The Igfbp2 Signaling Pathway In Glioma Development and Progression
… we did not yet know the key physiological pathways associated with this newly characterized oncogene.</p> <p>We first evaluated human glioma genomics data harnessed from the publicly available Rembrandt source to identify major pathways associated with IGFBP2 expression. Integrin and ILK, …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
… investigated the role of Notch 1 and 3 receptor signaling in controlling vascular SMC differentiation in vitro, and established a role for cyclic strain induced changes in Notch in mediating this response. The expression of smouth muscle cell specific a-atin, calponin, myosin and smoothdin was …
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Study on porphyromonas gingivalis- and porphyromonas endodontalis- mediated signaling pathway
It is known that anaerobic microbes like Porphyromonas gingivalis (P. gingivalis) are involved in the progression and initiation of multiple forms of periodontal disease such as chronic periodontitis. However, in order to culture this gram-negative anaerobic microbes in the laboratory we need a …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless signaling pathway and …
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The aryl hydrocarbon receptor signaling pathway and adverse reproductive outcomes
… the role of the aryl hydrocarbon receptor (AHR) signaling pathway and the circadian locomotor output cycles kaput (CLOCK) gene in experiencing adverse reproductive outcomes during the transition into reproductive senescence. Specifically, I examined the associations between selected genetic …
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Spatio-temporal investigation and quantitative analysis of the BMP signaling pathway
… in the developing embryos. Using the diverse signaling input information within the embryo due to the gradient, the cells transduce the varying extracellular information into distinct gene expression profiles and cell fate decisions. Furthermore, BMP proteins bear important functions in adult …
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Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
… an essential protein, Lst8, in TORC1 and TORC2 signaling and a previously uncharacterized complex, the Far3-7-8-9-10-11 complex (Far complex) in the budding yeast, <em>Saccharomyces cerevisiae</em>. Mutations in <em>SAC7</em> and <em>FAR11</em> suppressed lethality of both <em>lst8</em> and …
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Regulation of Skeletal Muscle Differentiation by a Rapamycin -Sensitive Signaling Pathway
… the potential partner proteins critical in mTOR signaling during skeletal myogenesis.
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless signaling pathway and …
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