Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"Signaling networks"”.
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Regulation of T-cell signaling networks
… or gene interactions, but to understand these networks of interactions as a whole. The goal of this thesis is to understand various aspects of how cells in general and T-cells in particular function, using models built from basic principles in chemical engineering, statistical physics and …
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Uncovering the Complexity of RAS Signaling Networks
… two important aspects to understanding the signaling complexity of any multiphenotypic arrangement, namely, the identification and examination of new effectors and the direct authentication of protein-protein interactions. We have identified a new Ras effector, IMP (Impedes Mitogenic signal …
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Pleiotropy and epistasis in auxin signaling networks
Plant hormones and their gene regulatory networks orchestrate a diverse array of metabolic and physiological changes crucial for growth, development, and environmental responses. Targeting the engineering of hormone signaling networks holds promise for enhancing plant health, crop productivity, and …
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An Evolutionary Computation Model of Intracellular Signaling Networks
… evolution of a particular class of intracellular signaling networks. This class of signaling networks mimics the cellular state transition (or mode switch) in a living cell in response to a specific number of prerequisites. Two different signaling regulations, namely absence receptor regulation …
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Relating topology and dynamics in cell signaling networks
… This capability is provided by interconnected signaling pathways. Many of the components and interactions within pathways have been identified, and it is becoming clear that the precise dynamics they generate are necessary for proper system function. However, our understanding of how pathways …
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Quantitative analysis of signaling networks in proneural glioblastoma
… murine model of proneural GBM, we quantified signaling networks using mass spectrometry. We identified oncogenic signaling associated with the GBM model, such as increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. Phosphorylation of CDK₁ Y₁₅, which causes G₂ /M …
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Proteomic Analysis Delineates the Signaling Networks of Plasmodium falciparum
… substrates of PfPK7 and to elucidate the signaling events that are regulated by PfPK7. In parallel to our experimental analysis, we used a computational approach for substrate prediction from our phosphoproteome dataset. This analysis identified 43 distinct phosphorylation motifs and a …
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On the Modeling of Signaling Networks with Petri Nets
… behavior arises from the interplay among signaling, metabolic, and regulatory processes. Proper modeling of the overall function requires accurate interpretations of each component. The highly concurrent nature of the inner-cell interactions motivates the use of Petri nets as a framework …
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Tools for investigating cellular signaling networks by mass spectrometry
… study of Epidermal Growth Factor Receptor (EGFR) signaling and phenotype prediction. The quantity of proteomic mass spectrometry data available from a single analysis has increased exponentially as new generations of instruments become quicker and more sensitive. This deluge of data leaves many …
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… stems from aberrant gene expression and protein signaling. In order to improve development of novel therapeutics, underlying mechanisms employed by malignant cells to maintain their function need to be deeply understood. The field of phosphoproteomics has advanced over the past few decades to …
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GPU-Optimized Graph Theory Analysis of Allosteric Protein Signaling Networks
Graph algorithms have been widely applied to science and engineering problems, but the practical applications of graph algorithms to every-growing, large data sets requires significant computational time, motivating the need for efficient, parallel solutions on modern computing architectures. Here, …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… developed tools is powerful to identify core signaling transduction networks, tumor vulnerability (master regulators) for novel cancer therapy.</p>
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Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… elucidate pathways involved in EGFRvIII receptor signaling, the global map of the signaling networks that it activates remains incomplete, making it difficult to assess downstream components involved in EGFRvill-mediated transformation. To gain a molecular understanding of the mechanisms by which …
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Reasoning on the response of logical signaling networks with answer set programming
Deciphering the functioning of biological networks is one of the central tasks in systems biology. In particular, signal transduction networks are crucial for the understanding of the cellular response to external and internal perturbations. Importantly, in order to cope with the complexity of …
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Design principles of mammalian signaling networks : emergent properties at modular and global scales
… global levels. Design principles of biological networks and cell signaling processes pertinent to disease progression emerge from these studies. It is my hope that knowledge of these principles may provide new mechanistic insights and conceptual frameworks for thinking about therapeutic …
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The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway
… consists of partial differential equations and signaling networks. Analysis techniques for these nonlinear reaction-diffusion equations included a study of the biological background and motivation, along with computational simulation of the various sets of models developed. The modeling effort …
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Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks
… to elucidate pathways involved in HER2 receptor signaling, the map of network-wide signaling events that contributes to the resistance to Tamoxifen treatment has not been characterized, making it difficult to pin-point the downstream drug target to revert the Tamoxifen resistance. To gain a …
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Mapping signaling networks and rapidly evolving genes in the developing Arabidopsis seed at single-nucleus resolution
Seeds are an exceptional evolutionary innovation that enables the conditional allocation of maternal resources to successfully fertilized ovules. During early development, seeds accumulate nutrients that are utilized either by the embryo or by humans who harvest seed crops for food, biofuel, and …
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