Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Signal transducer and activator of transcription 5"”.
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Sumo-Specific Protease 1 Controls Lymphoid Development Through Regulation of Sumoylation/Acetylation Switch In Stat5
… systems, but the physiological functions of SENPs are poorly understood. STAT5 (Signal Transducer and Activator of Transcription 5) plays a critical role in the development of lymphoid cells. However, it is not known whether STAT5 is regulated by the SUMOylation pathway. Here, we showed …
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Local regulation of increased milk yield due to early lactation increased milking frequency
… in yield is locally regulated within the gland; however the mechanism for the increase in yield is unknown. The objective of this study was to demonstrate a difference in milk and component yield, both during the IMF period and throughout the remainder of lactation, and examine potential …
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
High serum levels of the peptide hormone prolactin are associated with increased breast cancer risk and poor prognosis. Prolactin is also involved in breast cancer resistance to different chemotherapeutics. The overall goal of this project is to investigate potential pathways involved in prolactin …
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Growth Hormone and Nutritional Regulation of Insulin-Like Growth Factor-I Gene Expression
The objectives of this research were to characterize insulin-like growth factor-I (IGF-I) gene expression in cattle, to determine how IGF-I gene expression is affected by nutritional intake and growth hormone (GH) in cattle, and to identify the regulatory DNA region that mediates GH stimulation of …
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Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver
The overall objective of this research was to understand the mechanims by which growth hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression in liver. Previous studies have suggested that GH regulation of IGF-I gene expression in liver is mediated by binding of the …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
In the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin (PRL), act in concert with pathways regulated by the epidermal growth factor (EGF) family to control the growth and morphogenesis of this tissue during puberty, pregnancy and lactation. However, …