Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Signal transducer and activator of transcription (STAT)"”.
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Bedeutung der IL-6-Signaltransduktionsinhibitoren SHP2 und SOCS3 für die Desensitisierung des IL-6-Signalweges
The immediate early response of cells treated with IL-6 (interleukin-6) is the activation of the signal transducer and activator of transcription (STAT) 3. The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… increased smooth muscle cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… increased smooth muscle cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… increased smooth muscle cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, …
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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
Breast cancer is one of the leading causes of death of women in North America. Signal Transducer and Activator of Transcription (Stat)3 and Stat5 are transcription factors involved in normal breast development, and are hyperactivated in 30-50% of breast cancers. Stat5 is required for breast …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
Objective. The aim of this study was to determine the effects of interleukin-10 on mast cell development from bone marrow progenitors.Materials and Methods. Unseparated mouse bone marrow cells were cultured in IL-3+SCF, giving rise to mast cells and monocytes/macrophages. The addition of IL-10, and …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… are intracellular bacteria causative agents of gastroenteritis and typhoid fever in humans. Pregnancy poses an increased risk of severe Salmonellosis in many mammalian species contributing to miscarriage and/or maternal illness. Previous studies indicated that Salmonella infection in pregnant …
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Engineered biomaterials as extracellular microenvironments for guiding cell programming and reprogramming
The interface between cells and materials is a dynamic and complex environment where cells in contact with materials can sense their properties such as stiffness, matrix protein, and geometry and respond to these cues in multiple ways including through mechanical forces exerted on the matrix by the …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
<p>T cells comprise a substantial arm of the immune system and are exquisitely adapted to combat pathogens and tumors. The inflammatory environment largely dictates the nature of T cell response. A hallmark of T cell-mediated immunity is formation of immunological memory; the ability to respond …
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Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation
… by the latent accumulation in bone marrow of monoclonal plasma cells with a low proliferative index and an extended life span. Interleukin-6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the Signal Transducer and Activator of Transcription (STAT) …
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Antagonistic Roles of miR-199a-3p/miR-214 and the miR-200 Family in the Regulation of Uterine Contractility During Pregnancy and Labor
Progesterone (P4) and estradiol-17β (E2) play critical and opposing roles in regulating myometrial quiescence and contractility during pregnancy and labor (Kamel et al., 2010). While these contrasting hormonal effects are likely mediated via differential regulation of inflammatory and contractile …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
<p>Recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) is common; thus, it is essential to improve the effectiveness and reduce toxicity of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has …
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Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver
The overall objective of this research was to understand the mechanims by which growth hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression in liver. Previous studies have suggested that GH regulation of IGF-I gene expression in liver is mediated by binding of the …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… (MPNs) commonly result from the acquisition of somatic mutations affecting the Janus kinase 2 (JAK2) (such as JAK2<sup>V617F</sup>) or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal transducer and …
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Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
… metabolic functions but are also a major source of damaging reactive oxygen species (ROS) and harbour pro-apoptotic factors. Multiple homeostatic processes operate to maintain mitochondrial integrity; however, terminally damaged organelles are degraded through the process of targeted …
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Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
… unterschiedliche Weise in die IFN-γ-induzierte Signaltransduktion eingreifen. Das Molekül des Parasitenlysats, das an der Inhibierung der MHC Klasse II Expression beteiligt zu sein scheint, ist teilweise sensitiv gegen Behandlung mit Pronase, was auf die Involvierung eines Proteins hinweist. …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… GTPases (i.e. Rho, Rac, Cdc42) as mediators of diverse critical cellular processes, such as actin cytoskeleton remodeling, gene transcription, cell-cell adhesion, and cell cycle progression. However, more recent data highlight an essential role for Rho GTPases as regulators of neuronal …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… is a tyrosine kinase involved in the development of the gut and nervous system, initially cloned from cases of T-cell lymphoma. ALK has been frequently implicated in diverse cancers through oncogenic translocations, mutations, chromosomal inversion, or amplification events. Such translocations or …