Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Signal integration"”.
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Mechanisms of signal integration: Regulation of the SPI1 T3SS
… tightly regulated, with many of the activating signals acting at the level of hilD translation or HilD protein activity. Once inside the phagosome of epithelial cells, or in macrophages during systemic stages of disease, the SPI1 T3SS is no longer required or expressed. Here we show that the …
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Bioprobes and Genetics Reveal the Signal Integration That Initiates Dendrites in a Neuron in Vivo
… rearrangements by orchestrating intrinsic signaling molecules. Monomeric Rho GTPases are capable of mediating diverse transmembrane signal pathways. However, the means to monitor and dissect molecular signaling within a subcellular compartment are limited, and the role of Rho GTPases and …
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The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
… (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) crosstalk and explored the mechanism involved …
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Synthetic biological circuits for continuous signal processing
… cells will need to be capable of similar signal processing and computation in order to operate efficaciously in complex environments, like the human body. In this thesis I describe the development of synthetic biological circuits that enable such capabilities. In the first chapter, analog …
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Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito
… of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, migration, survival and death. These signaling pathways do not act independently, but rather are …
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Modality related effects of face and voice information and the perception of human attractiveness
… to identify a suitable mate. Utilising multiple signals for sexual selection could be advantageous since together these might limit the chance of mating with a suboptimal partner (Møller & Pomiankowski, 1993) and thus avoid the cost of unhealthy progeny. However to date, research has focused …
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Characterization of split ends function during Drosophila eye development
Conserved signal transduction pathways coordinate all aspects of metazoan development, including cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling pathways interface to create a web of specific interactions that a cell …
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Structural and Spectroscopic Characterization of Modular Photoreceptors
Photoreceptors are signaling proteins that perceive a light signal and generate light-dependent biochemical responses. Cyanobacteriochromes (CBCRs) from photosynthetic cyanobacteria are an emerging family of bilin-based photoreceptors that are compact in size and diverse in absorption spectra. …
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Interrogating the molecular mechanism of signal transduction in the TGF-β receptor superfamily
A major unanswered question in cellular signalling is how binding of an extracellular ligand to its cell-surface receptor triggers activation of an intracellular signalling cascade to achieve a physiological response. TGF-β signalling is central to many physiological processes, from embryonic …
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Mathematical modeling of macronutrient signaling in Saccharomyces cerevisiae
In eukaryotes, distinct nutrient signals are integrated in order to produce robust cellular responses to fluctuations in the environment. This process of signal integration is attributed to the crosstalk between nutrient specific signaling pathways, as well as the large degree of overlap between …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… cells "home" to a central region in which the signals from multiple chemokines are balanced. These results provide fundamental insight into the processes that DCs use to migrate toward and position themselves within secondary lymphoid organs. We extended this work to a combination of the …
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Gated multi-cycle integration (GMCI) for focal plane array (FPA) applications
… the model and the theory of gated multi-cycle integration (GMCI) were first developed specifically for focal plane array dealing with repetitive or modulated image. The operational modes of GMCI include gated integration (GI), phase sensitive integration (PSI), multi-point summation, …
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Modeling the function of the cerebellum in scheduled linear servo control of simple horizontal planar arm movements
… linear combinations of command and feedback signals that ensure passive, and therefore stable communication despite delays and changes in loads. The signal integration employed in wave-variable teleoperation may be viewed as implementing a rudimentary linear internal model of limb dynamics. …
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The role of intensity, temporal synchrony, and biogenic amines for unimodal and multimodal integration during learning and memory of honey bees and bumble bees
… investigates the interplay between bimodal signal integration, multisensory processing, and the role of biogenic amines in learning and memory tasks of honey bees and bumble bees. The three chapters provide valuable insights into these interconnected concepts and on the mechanisms underlying …
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Characterisation of primary cilia in human hypothalamic neurons
… However, how cilia exert their role as signalling hubs in those neurons remains largely unknown. We set out to better understand the role of primary cilia in the control of food intake by hypothalamic neurons. We hypothesised that primary cilia might act as a signal integration centre …
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Competition-based CRISPR-dCas9 transcriptional control mechanisms and application of dCas9 biosensors for high-throughput, cell-based protease inhibitor screens
… use overlapping binding sites as a mechanism for signal integration, where the binding of one transcription factor can augment the activity of another. Here, I implement this strategy in Escherichia coli using pairs of sgRNAs designed to repress and then derepress transcription through competitive …
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Multi-scale models of T cell activation
… suggested that T cells may integrate sub-optimal signals derived from successive encounters with DCs to achieve full activation. However, an underlying molecular mechanism that may confer such "short term memory" of exposure to Ag is not known. I explored the possibility that the hysteresis …
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Biochemical Reconstitution and Functional Characterization of the WAVE Regulatory Complex
… role in the transmission of the extracellular signals to the actin cytoskeleton. These proteins use their C-terminal VCA domain to stimulate the actin-nucleating activity of Arp2/3 complex in response to upstream signals from the Rho family GTPases Cdc42 and Rac1. While WASP regulation by …
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Gating Mechanisms of The Canonical Trp Channel Isoform Trpc4
… activated downstream from phospholipase C (PLC) signaling. However, the mechanism by which the PLC pathway activates TRPC4/C5 remains unclear. Uniquely, TRPC4 is maximally activated only when two separate G protein pathways, G<sub>q/11</sub> and G<sub>i/o</sub>, are co-stimulated, making it a …
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THz Radiation Detection Based on CMOS Technology
… In terms of low cost, high volume, and high integration capabilities, standard CMOS technology has been considered as an excellent platform to achieve fully integrated THz imaging systems. In this Ph.D. thesis, we report on the design and development of field effect transistor (FET) THz …
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