Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Sigma-1 Receptor"”.
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… (mTOR). Preclinical studies suggest that sigma-1 receptor agonists produce antidepressant-like drug effects and affect the mTOR pathway. Other mechanisms include serotonin neurotransmission and N-methyl-D-aspartate (NMDA) receptors. This study evaluated drugs acting as sigma-1 agonists, …
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Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
Dysfunction in the Sigma-1 receptor (Sig-1R) is implicated in many neurodegenerative diseases such as Alzheimer’s Disease (AD). Recently, agonists of the Sig-1R have been found to be neuroprotective in AD and provide significant improvements in symptoms. The hallmarks of AD are aggregation of …
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Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse
… the development of new pharmacotherapies, CM304 (sigma-1 receptor antagonist), mitragynine and 7-hydroxymitragynine (μ-opioid receptor agonists), for the treatment of drug abuse. The affinity of cocaine to sigma-1 receptors render the hypothesis that targeting sigma-1 receptors using antagonists …
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Molecular modeling of sigma 1 and sigma 2 receptor ligands: pharmacophore development and comparison using discotech and bioactivity prediction comparison of ab initio and density functional comfa studies for spiro and other receptor ligands
The role of the biological receptor is currently being studied by researchers in medicine. Information about sigma receptors in particular can be gained by studying the ligands associated with each type, sigma 1 or sigma 2. Sigma 1 receptor ligands consist of drug candidates that often have …
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Pharmacophore derivation using discotech and comparison of semi-emperical, AB initio and density functional CoMFA studies for sigma 1 and sigma 2 receptor-ligands
… of pharmacophore and CoMFA models for sigma receptor ligands. CoMFA studies were performed for 48 bioactive sigma 1 receptorligands using [H^3 ](+) pentazocine as the radioligand, for 30 PCP derivatives for sigma 1 receptor-ligands using [^3H](+)SK-F 10047 as the radioligand and for 24 …
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role of pentazocine in an in vitro model of hypoxia/reoxygenation
… toxic and protective brain innate immunity. Sigma-1 receptor is expressed in both neurons and glia is a unique class of intracellular proteins and is involved in neurodegeneration. Our aim was to evaluate the biological effects of sigma-1 selective ligands, and bifunctional sigma-1 selective …
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Studies on Macrophage Migration in Pathological Contexts
… molecule that signals through purinergic receptors. ATP, probably released from damaged neurons, can promote the migration of macrophages and microglia to the site of injury, and can be responsible for the onset of neuropathic pain. Purinergic signalling via ATP and other nucleotides is …
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From Forest Floors to Pharmacology: Elucidating Millipede Defensive Alkaloids for Drug Discovery
… that a subset of the alkaloids potently binds to sigma-1 receptor (ischnocybine A: Ki 14 nM), while others bind to sigma-2 (homo-hydrogosodesmine hydrate: Ki 260 nM). Furthermore, ecology studies revealed that the alkaloid production is conserved over large geographical regions, accumulated as the …
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Expression of sigma receptors in human cancer cell lines and effects of novel sigma-2 ligands on their proliferation
Sigma receptors originally thought to be an opioid receptor is now categorized as a distinct class of receptor. There are two main subtypes, the sigma-1 receptor and an uncharacterised binding site, named the sigma-2 binding site. The presence of the sigma-2 binding site shows high correlation with …
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Design, synthesis, and biological evaluation of sigma receptors (σRS) ligands as potential pharmacotherapy for cancer and drug addiction
Sigma receptors are a well-defined unique class of receptors and are highly expressed in the central nervous system and also widely distributed in peripheral organs and tissues. There are two subtypes of sigma receptors: sigma-1 and sigma-2. These receptors are thought to be associated with …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
… the autophagic response. The involvement of sigma 1 receptor, and autophagy signaling proteins p-mTOR, Atg5, Atg7, and p-Bcl-2/Beclin-1 were determined by using selective inhibitors and siRNAs. In addition, we determined the role of autophagy in chronic cocaine exposure using MTT assay and …
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Interactions of Proteins with Membranes: Insights from Molecular Dynamics Simulations
… level; for instance, the recognition of membrane receptors or specific lipids, the identification of the residues at the protomer interfaces that are crucial for oligomerization, and the analysis of the conformational rearrangements that are required for pore formation. In this work, I applied MD …