Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Sideroflexin"”.
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Expression, Purification and Molecular Characterisation of Sideroflexin Proteins
Members of the sideroflexin family are poorly characterised membrane proteins of the mitochondrial inner membrane. Understanding their function is now a high priority, as patients have been identified who carry mutations in human sideroflexin 4, causing a severe mitochondrial, neurological and …
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Mitochondrial protein SFXN3 as a novel target in neurodegenerative diseases
… which is a modulator of synaptic pathology, and Sideroflexin 3 (SFXN3) was identified as a mitochondrial protein that modulates synaptic morphology in vivo. This finding prompted the aims of this thesis: biochemical characterisation of SFXN3; the identification of SFXN3’s molecular interactors …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
… and in vitro cell systems we identified sideroflexin 3 (sfxn3). We show sfxn3 is localized at the inner mitochondrial membrane and that it functions outside the main canonical pathways of mitochondria energy production. In addition, overexpression of sfxn3 in Drosophila led to a …