Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Sidechains"”.
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Poly(Phenylene vinylene) And Poly(Naphthalene vinylene) Derivatives for Use in Organic Light-Emitting Diodes (OLEDs)
… The role of oxygen in the solubilizing sidechains of conjugated polymers was investigated. When oxygen is removed from these sidechains, the solubility and device performance are adversely affected. Incorporation of oxygen in the chain in a position further from the aromatic ring …
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The Delayed Neurotoxicity of Thio-, Allylthio- and Dithio-Carbamates and Its Relevance to a Mode of Action
… thiocarbamates bearing short, unbranched alkyl sidechains. The toxicity of these compounds was further examined in Musca domestica (LD(,50)) and Culex quinquefasciatus (LC(,50)) to discern correlations between esterase inhibition and delayed neurotoxicity.
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… with covalently linked glycosasminoglycan (GAG) sidechains, which are thought to mediate proteoglycan-ligand interactions. UDP-glucose dehydrogenase (Ugdh) is an enzyme required for the biosynthesis of GAGs, and in its absence the cell cannot polymerize sidechains. Drosophila mutant embryos …
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Chemical Mutagenesis for the Modulation and Study of Protein Function and Dysfunction within Alzheimer’s Disease
… interconversion of amino-acid (AA) sidechains. This approach enabled the first ever point-mutations in proteins and has seen a resurgence of interest over the last two decades. This thesis reports on two disparate applications of chemical mutagenesis within the context of Alzheimer’s …
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Chemical Methods for Cobalt-Catalysed C(sp3)–H Activation and Iodonium Salt-Mediated Peptide Functionalisation
… high chemoselectivity with respect to peptide sidechains. Excellent conversions were achieved in five minutes at room temperature, demonstrating the potential of this process for bioorthogonal labelling.
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Synthesis and Design of ClpP Activators as Novel Antibiotics
… MIC activity, but attaching siderophore sidechains to the southern proline via a short linker does not confer broad-spectrum activity to UDEPs.</p>
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Molecular substrate design for the selective adhesion, proliferation and differentiation of marrow connective tissue progenitors
… backbone with 10-mer poly(oxyethylene) sidechains was selected as the vehicle to present small adhesion peptides at the surface. This polymer shows excellent performance in cell resistance studies and offers sufficient functionalizable sites to create high local densities of ligands. …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… Attachment of hydrocarbon or perfluorocarbon sidechains provides amphiphilicity to produce the multimodal self-assembling micelles. Additionally, encapsulation procedures for chemotherapeutic agents, doxorubicin and paclitaxel, have been established.
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Binding Affinity of Flavins to the Dehydrogenase Domain of SpNOX
… clashes between FAD, NADPH and multiple sidechains still raises questions on actual structural activity.<sup>1</sup> The structural similarities within the NOX family make SpNOX (<em>Streptococcus pneumoniae</em> NOX), a bacterial NOX homolog with vigorous activity in detergents, ideal …
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PUBLIC BLOCKCHAIN SCALABILITY: ADVANCEMENTS, CHALLENGES AND THE FUTURE
… Witness (Segwit), Sharding, and two-way pegged sidechains. Although these proposals are innovative, they still suffer from the blockchain trilemma of scalability, security, and decentralization. Moreover, at this time, little is known or discussed regarding factors related to design choices, …
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Ontwikkeling van spirocyclische vitamine D3 analoga met potentiële dissociatie van biologische activiteiten
… the sidechain are attached. Also a variety of sidechains is tested on their influence on the biological activity. (1) R. Bouillon, W.H. Okamura, Norman, A.W. Endocr. Rev. 1995, 16, 200‐257; (2) W. Schepens et al. Org. Lett. 2006, 8, 4247‐4250; (3) G.‐D. Zhu, W.H. Okamura, Chem. Rev. 1995, 95, …
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… a biotin moiety in place of one of the imidazole sidechains was developed. Chemosensitivity studies confirmed that the biotinylated compounds retained their activity showing IC50 = 6.25 ¿M in a susceptible cell line, compared with > 100 ¿M for an insensitive cell line. The biotinylated ligands …
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Exploring Protein-Ligand Interaction with Rotamer-Library Based Refinement Tools
… used for the predicting and refining protein sidechains, loops and tertiary structures. These refinement techniques have been expanded to allow the inclusion of protein-ligand interactions by developing and evaluating methods for creating rotamer libraries for small drug-like molecules. Two …
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Strategies towards the synthesis of prostaglandin analogues
… Having demonstrated that the a- and p- sidechains could be installed, the key rDA reaction has been used to generate target analogues. The second approach utilizes a Diels-Alder cycloaddition reaction as the key step. The thermal and Lewis-acid catalysed Diels-Alder reactions between …
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Collagen-mimetic peptides for diagnosis and analysis
… of molecular modifications on its amino acid sidechains. This thesis explores the application of CMPs in diagnostic applications, in which CMPs detect aberrations in native collagen, and analytical contexts, in which CMPs act as a simplified system to understand collagen biochemistry. Chapter …
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Helical Pitch, Hydrophobic Binding, Chiral Templation, and Supramolecular Chelation of M-Phenylene Ethynylene Foldamers
… oligomer with longer hexaethylene glycol sidechains was designed and synthesized to understand the binding properties of the hydrophobic helical cavity in aqueous solutions of acetonitrile. It was found to have an association constant with (-)-alpha-pinene of 1.4 +/- 0.09 x 106 M-1 in 90% …
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Integration Host Factor and Its Interaction With the H-Prime Site of Bacteriophage Lambda
… site. Substitution with a variety of amino acid sidechains demonstrates that both oxygens of the glutamic acid sidechain are required for full discrimination against the TAG variant. In the cocrystal, the oxygens of the glutamic acid make bonds with two flanking arginines but do not contact the …
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Fourier transform infrared difference spectroscopy of bacteriorhodopsin
… compounds. This comparison revealed that the sidechains of these amino acids undergo changes in protonation and/or environment during the photocycle, functioning, as had been thought, as proton donors and acceptors. However, we were not able to construct a synoptic model of the role of these …
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Singlet Fission in Pechmann Dyes and Molecular Oligomers
… electron spin resonance. Thereafter, we engineer sidechains of Pechmann dyes and investigate their solid-state structure-function relationship and spin physics in these derivatives. We show that one can effectively tailor singlet fission dynamics by engineering polyene side chains. Finally, we …
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Meningeal Fibrosis in the Axolotl Spinal Cord: Extracellular Matrix and Cellular Responses
… of glycosaminoglycans that are used in sidechains of both unsulfated and sulfated proteoglycans, while simultaneously remodeling the ECM through the production of MMPs and phagocytosis of cellular debris. Further, this study shows that mesenchymal ependymal cells and a population of …
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