Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Sickness Behavior"”.
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Serotonin-Mediated Sickness Behavior
… how serotonin governs the internal state of sickness. In addition to activating the immune system and remodeling physiology, pathogenic infection results in adaptive behavioral changes that promote survival. These 'sickness behaviors' are observed throughout the animal kingdom. I induced …
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Neural Control of Sickness Behavior
… and changes in temperature, collectively termed sickness, during infections. While these responses have been shown to be adaptive for animal survival during infection and have been attributed to the central nervous system, the underlying control mechanisms for this response have not been …
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Peptidergic Signaling Controls the Dynamics of Sickness Behavior in Caenorhabditis Elegans
… is accompanied by modifications to host behavior that promote recovery and survival. The neural and molecular mechanisms that rule the switch to a sickness behavioral state are an active area of research. One established model for sickness behavior is the interaction between …
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Sulforaphane as a potential nutritional intervention to reduce neuroinflammation associated with aging and sickness behavior
… and produce immune factors that drive adaptive sickness behaviors to facilitate recovery from acute illness and injury. Microglia, the resident innate immune cells in brain, recognize pathogens and danger associated molecular patterns, then express proinflammatory signaling molecules such as …
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Behavioral change in response to low-grade non-infectious stimuli: findings and potential neuroimmune mechanisms
… these symptoms comprise what is recognized as “sickness behavior.” Sickness behavior represents a conserved, motivational behavioral state that, with the induction of fever, serves to help an organism combat infection and ultimately survive. Long dismissed as an unavoidable consequence of the …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… system output, endocrine system output, and behavior to regulate the body’s response to infection. One host factor affecting the behavioral response to infection is aging. Due to microglia priming and exacerbated neuroinflammation, aged individuals exhibit prolonged sickness behavior and …
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Investigação de parâmetros bioquímicos em dois modelos animais de depressão induzidos por desamparo aprendido e administração do lipopolissacarideo de E.Coli
… oxidative damage on serum and PFC and helpless behavior. There was no difference in the concentration of IL-1β, TNFα, IL-6 and IL-10 cytokines on PFC and hippocampus of the animals exposed to the learned helplessness test, but there was a significant positive correlation between IL-6 …
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Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
… cytokine response, as well as prolonged behavioral and cognitive deficits when compared to adults. This is attributed to a population of activated or “primed” microglia that produce excessive amounts of pro-inflammatory cytokines, such as interleukin (IL)-6. The over production of IL-6 …
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Epigenetic regulation of neuroinflammation in the aged mouse brain
… IL-1β production, as well as prolonged sickness behavior. We also determined changes in epigenetic regulator gene expression with both age and LPS. Furthermore, we found that inhibiting DNA methylation increased Il1b gene expression and decreased DNA methylation of BV2 and primary …
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
… and virulent E. coli infection caused severe sickness mediated by TRPV1+ TLR4+ sensory neuron detection of the exposed lipopolysaccharide (LPS). Stimulation of lung nociceptors induced acute stress responses in the paraventricular hypothalamic nuclei by activating corticotropin-releasing …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… improved mood and cognition, and resistance to sickness behaviors such as anorexia and fever. The mechanisms underlying fasting-induced health benefits and alterations in immunity and sickness behavior continues to remain debated despite over 20 years of interest. This research project confirms …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
… is thought to be involved in the induction of sickness behavior by lipopolysaccharide (LPS). In the first study, the ability of LPS to induce ICE in microglia was examined. Determined by RT-PCR, ICE mRNA was constitutively expressed in murine microglia cell line N13 cells and primary microglia …
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Effects of a high cholesterol diet on the pathogenesis of influenza A virus infection in mature mice
… and food disappearance were recorded daily and sickness behavior was evaluated by a burrowing behavior test. Circulating free cholesterol and triglycerides were measured at each time point and diet-induced changes to liver appearance were evaluated at day 16 p.i. Diet-induced changes to T and B …
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Effects of ambient temperature on mechanisms of pathogen transmission in house finches (Haemorhous mexicanus)
… and often exclude endothermic taxa, which modify behavior and energy allocation strategies in colder environments in ways that could increase pathogen spread. Additionally, because many endotherms serve as important reservoirs for zoonotic diseases and are facing conservation threats due to …