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Showing 1 to 20 of 28 for “"Sickle cell anemia"”.
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Rheological aspects of sickle cell anemia and related hemoglobinopathies
… on patients with the following diseases: normal, sickle cell, sickle cell trait, sickle cell hemoglobin C, homozygous hemoglobin C, sickle cell beta plus thalassemia, and sickle cell beta zero thalassemia. The rheological parameters obtained from a Casson's plot were the apparent yield stress and …
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Impact of Hydroxyurea on Neurocognitive Function and Quality of Life in Children with Sickle Cell Anemia
Background: Beginning in infancy, children with sickle cell anemia (SCA) experience severe anemia, acute and chronic pain, fatigue, and progressive multi-organ damage including a substantially increased risk of stroke during childhood. Neurocognitive deficits and poor health-related quality of life …
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The effects of a perceptual interaction conference on the self-concept of adolescents with sickle cell anemia
… on the self-concept of adolescents with sickle cell anemia. Twelve females between the ages of 13 and 18 years with a confirmed diagnosis of sickle cell anemia were randomly assigned into either the experimental or control groups. The experimental group participated in four weekly 1-hour …
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Manifestações clínicas e diagnóstico laboratorial da doença falciforme : uma revisão sistemática.
Sickle cell anemia is a chronic hemolytic disease , the most common hereditary character in Brazil. The objective of this study was to accomplish systematic revision on the clinical complications and types of diagnosis of the bearers of that disease , as well as showing the gr eat importance of …
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Preventing and Treating Complications of Sickle Cell Disease in Pediatric Patients
<p>Preventing and Treating Complications of Sickle Cell Disease in Pediatric Patients Sickle cell anemia, also known as sickle cell disease, affects over 90,000 people in the United States alone with those of African descent being at greater risk (Dobson & Byrne, 2014). Worldwide, it affects over …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
… ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD …
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A Free Heme Perspective to Sickle Hemoglobin Polymerization
Sickle cell hemoglobin (HbS) polymerization is considered to be the primary pathogenic event in the sickle cell anemia. Many cellular and molecular factors have been identified so far as contributor towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small …
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Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease
… correlates with laboratory data in children with sickle cell anemia as measured by the Sysmex Automated Hematology Analyzer. METHODS USED: Hemoglobin measurements were taken at Children’s Medical Center in Dallas from patients under the age of 18 with a diagnosis of sickle cell anemia. In …
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The Roles of Krüppel-like Transcription Factors KLF1 and KLF2 in Mouse Embryonic and Human Fetal Erythropoiesis
… worldwide. Although the pathophysiology of sickle cell anemia and beta-thalassemia, two of the most common hemoglobinopathies, have been the focus of much research over the last century, patients affected by these diseases still lack a widely applicable and easily available cure. Sickle cell …
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ΤΟ ΕΠΙΠΕΔΟ ΤΟΥ 2,3-ΔΙΦΩΣΦΟΡΟΓΛΥΚΕΡΙΝΙΚΟΥ ΟΞΕΩΣ ΤΩΝ ΕΡΥΘΡΩΝ ΑΙΜΟΣΦΑΙΡΙΩΝ ΣΤΗΝ ΔΡΕΠΑΝΟΚΥΤΤΑΡΙΚΗ ΝΟΣΟ
… IN 32 CONTROL-SUBJECTS; II) IN 18 PATIENTS WITH SICKLE-CELL ANEMIA; III) IN 23 PATIENTS WITHSICKLE-THALASSEMIA; IV) IN 51 INDIVIDUALS WITH SICKLE-CELL TRAIT AND V) IN 18INDIVIDUALS WITH B-THALASSEMIA TRAIT. IN GROUP I, 2,3 DPG LEVEL WAS SIGNIFICANTLY HIGHER IN WOMEN THAN IN MEN AND A NEGATIVE …
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Scope: A Protein Force Field With An Artificial Neural Network Approach to Protein Refinement
… play important roles in diseases such as sickle cell anemia, Alzheimer's disease, and Parkinson's disease to name a few. Current protein force fields such as those implemented in CHARMM, AMBER, NAMD, and Xplor-NIH have many individual force terms that include bonded and non-bonded …
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Analysis Of The Mouse p100H Mutation: Implications For Two Disease Related Genes: P and Sox6
… function of the transcription factor Sox6 in red cell development and in the silencing of epsilon globin, an embryonic globin gene. This finding bears significance in the field of globin gene regulation and has an important potential in the development of new therapeutic strategies for treating …
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Microfluidic devices for analysis of red blood cell mechanical properties
Decreased deformability of human red blood cells (RBCs) is both a cause of disease and biomarker for disease (1). To traverse blood capillaries, the biconcave disk-shaped RBC must deform dramatically, since the diameter of the unconstrained RBC is larger than that of the capillaries. If the RBC …
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A molecular dynamics simulation based principal component analysis framework for computation of multi-scale modeling of protein and its interaction with solvent
… of mutated hemoglobin molecules that cause sickle cell anemia and the atomic level details of which are unknown. The new methodology reveals slow motion processes of the hemoglobin-hemoglobin interaction. MD based PCA is computationally expensive. Thus, this dissertation work also includes a …
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On the theory of the optical stretcher : optics, mechanics, and thermal effects
… deforming micron-sized particles or biological cells. It can be employed to measure cell-mechanical properties and, thus, to monitor physiological changes, such as differentiation, and to diagnose diseases that affect the structural integrity of cells, like cancer and sickle-cell anemia. To …
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Membrane Stabilizing Copolymer Poloxamer 188 in Preclinical Models of Acute Myocardial Infarction Reperfusion
… shock and cardiac arrest remain very high. Cellular injury after acute myocardial infarction occurs in two stages- ischemic injury, which occurs when there is a myocardial oxygen supply-demand mismatch, and reperfusion injury, which occurs with the sudden unrestrained return of blood to the …
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Dynamic behavior of healthy and malaria infected human red blood cells
… network and membrane of human red blood cells (RBCs). These structural changes lead to altered cell shape, deformability, cytoadherence and rheology which may in turn, promote the onset of vaso-occlusive events and crises that may ultimately cause pain, stroke, organ damage and possibly …
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MARKOV STATE MODELS AND THEIR APPLICATIONS IN PROTEIN FOLDING SIMULATION, SMALL MOLECULE DESIGN, AND MEMBRANE PROTEIN MODELING
… to form its unique structure. For example, sickle cell anemia is caused by a single mutation that changes glutamic acid to valine. Molecular dynamics (MD) simulations could be utilized to study protein folding and effects of perturbations on protein energy landscape; however, due to its …
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