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Showing 1 to 20 of 122 for “"Sickle Cell Disease"”.
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Sickle cell disease
Sickle cell disease is a group of disorders that affects hemoglobin, and causes distorted sickle- or crescent- shaped red blood cells. It is a genetic disease acquired by the inheritance of two abnormal hemoglobin S genes (HbS), one from each parent. SCD is most common among people from Africa, the …
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Understanding Fatigue in Pediatric Sickle Cell Disease
… SCD that functions in relation to other disease symptoms. Clinically, these findings suggest the need for consistent screenings for fatigue symptoms and sleep problems in youth with SCD, as well as interventions targeting poor sleep and pain to address issues of fatigue in youth with SCD.
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Health Care Transitions in Sickle Cell Disease
… decades, advances in the care for children with sickle cell disease (SCD) have increased their life expectancy and necessitated their transition to adult health care. However, there is a limited understating of health care transition in SCD and the impact it has on outcomes beyond perspective on …
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Sickle cell disease awareness amongst college students
… treatments, and genetic counseling methods for sickle cell disease. This study was also devised to determine whether or not students, who are more likely to be genetically affected by sickle cell disease, are more or less aware of their sickle cell disease status. Two hundred and fifty- nine …
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Priapism Among Male Adolescents with Sickle Cell Disease
… of priapism among male adolescents with sickle cell disease (SCD). A painful genetic disorder with no cure, SCD severely impacts the lives of patients, as well as their families and friends. Priapism is one of the complications of SCD and involves persistent and painful penile erections. …
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Pulmonary hypertension in adolescents with sickle cell disease
Sickle cell disease consists of a group of disorders that have a similar mutation in at least one of the beta-globin chains of hemoglobin. This results in a change of the hemoglobin to sickle shaped cells when in the deoxygenated state. It is these sickled cells that lead to the symptoms and …
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Yoga Therapy for Chronic Pain in Sickle Cell Disease
BACKGROUND: Patients with sickle cell disease suffer from both acute and chronic pain that severely affects their quality of life. Acute pain secondary to vaso-occlusive pain crises are a frequent cause of hospitalization and missed days from school and work. Many adult patients also suffer from …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
<p>Sickle cell syndromes increase the risk of rhabdomyolysis, a potentially life-threatening condition stemming from the destruction of skeletal muscle fibers. Acute kidney injury (AKI), a major complication of rhabdomyolysis, contributes to long-term morbidity through the development of chronic …
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Healthcare Resource Utilization in Persons with Sickle Cell Disease
… of this study were to determine prevalence of sickle cell disease (SCD) in a Medicaid population, to determine all-cause health care resource utilization and incremental health care resource utilization associated with SCD. An observational database analysis was conducted using information from …
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Risking Reproduction: Reproductive Health Among Women With Sickle Cell Disease
<p>Reproductive health among women with sickle cell disease remains a critical gap in the literatures on sickle cell disease, reproductive health, and women's health. Sickle cell disease (SCD) is a condition with a complicated clinical sequelae, accompanied by a myriad of health complications, …
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
<p>Sickle cell disease (SCD) is a dangerous condition caused by a genetic mutation on the human beta-globin gene that contributes to erythrocyte sickling, the hallmark of the disease. Previous metabolomics studies have confirmed that elevated sphingosine kinase 1 (SphK1) mediates …
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Sickle Cell Disease Nursing Education: A Mixed Methods Program Evaluation
<p>INTRODUCTION AND BACKGROUND: Sickle cell disease (SCD) is a common disorder of the hemoglobin and affects more than 100,000 people in the United States and millions worldwide. In response to a drastic lack of available education a group of SCD experts developed the Sickle Cell Boot Camp to …
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Novel approach towards pathogenesis and treatment of sickle cell disease
Sickle cell disease (SCD) is one of the most common genetic diseases worldwide. HbS polymerisation causes altered red blood cell (RBC) rheology and fragility, increase in blood viscosity with blockage of small blood vessels, and RBC membrane permeability changes. Excessive levels of cell-free Hb, …
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Paediatric cardiac anaesthesia in sickle cell disease : a case series
Sickle cell disease (SCD) is the most common inherited haematological disorder, producing a mutation of the haemoglobin molecule known as haemoglobin S (HbS). The presence of HbS in the erythrocyte makes it prone to sickling - a process which may lead to vaso-occlusive injury, haemolysis and a …
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Effects of Sickle Cell Disease on Growth of the Craniofacial Complexes
<p>Sickle cell disease (SCD) is a genetic disorder affecting over 100,000 African Americans. While once lethal, medical treatment now allows those with SCD to lead comparatively normal lives, and these children are more frequently seeking orthodontic treatment. We report here on a cephalometric …
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UNDERSTANDING THE SEXUAL EXPERIENCES OF PEOPLE LIVING WITH SICKLE CELL DISEASE
Background: Sickle cell disease (SCD) is a blood disorder that mostly affects people of African heritage. The most known symptom of SCD is a pain crisis. A pain crisis is when red blood cells sickle in the blood vessels and cause intense, often debilitating pain. Until the late 1990s, SCD was seen …
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Characterization of Bone Pathology in Sickle Cell Disease and Therapeutic Strategies
<p>Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern. While the advances in medical treatment and management of SCD during childhood have drastically improved the overall survival of children, the transition from pediatric to adult services is …
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Preventing and Treating Complications of Sickle Cell Disease in Pediatric Patients
<p>Preventing and Treating Complications of Sickle Cell Disease in Pediatric Patients Sickle cell anemia, also known as sickle cell disease, affects over 90,000 people in the United States alone with those of African descent being at greater risk (Dobson & Byrne, 2014). Worldwide, it affects over …
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Genomics of sickle cell disease and fetal hemoglobin in African populations
Background More than 300,000 babies are born with sickle cell disease (SCD) each year. About 79% of these births occurs in sub-Saharan Africa where the sickle variant is known to have originated in the genetic background of the ancestors of Agriculturalist populations. Although the variant is …
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Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease
… of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however are clear. Ten percent of sickle cell disease patients will have a stroke by the age of 20. Two thirds …
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