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Showing 1 to 20 of 153 for “"Sickle Cell"”.
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Sickle cell disease
Sickle cell disease is a group of disorders that affects hemoglobin, and causes distorted sickle- or crescent- shaped red blood cells. It is a genetic disease acquired by the inheritance of two abnormal hemoglobin S genes (HbS), one from each parent. SCD is most common among people from Africa, the …
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Understanding Fatigue in Pediatric Sickle Cell Disease
Fatigue is a problematic symptom for adults with SCD and other pediatric populations, but less is known about the experience of fatigue for youth with SCD. The present study described the experience of fatigue in children and adolescents with SCD, and examined the combined and unique influences of …
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Health Care Transitions in Sickle Cell Disease
… decades, advances in the care for children with sickle cell disease (SCD) have increased their life expectancy and necessitated their transition to adult health care. However, there is a limited understating of health care transition in SCD and the impact it has on outcomes beyond perspective on …
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Sickle cell disease awareness amongst college students
… treatments, and genetic counseling methods for sickle cell disease. This study was also devised to determine whether or not students, who are more likely to be genetically affected by sickle cell disease, are more or less aware of their sickle cell disease status. Two hundred and fifty- nine …
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Haematological and nutritional status of Sudanese women with sickle cell trait and anaemia: does sickle cell trait compromise birth outcomes?
… status of Sudanese women who have both sickle cell trait and sickle cell anaemia and has considered whether women with sickle cell trait experience worse outcomes of childbirth than those without. Non pregnant group with sickle cell anaemia: In this study, (n=39) sickle cell anaemia and …
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Priapism Among Male Adolescents with Sickle Cell Disease
… of priapism among male adolescents with sickle cell disease (SCD). A painful genetic disorder with no cure, SCD severely impacts the lives of patients, as well as their families and friends. Priapism is one of the complications of SCD and involves persistent and painful penile erections. …
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Pulmonary hypertension in adolescents with sickle cell disease
Sickle cell disease consists of a group of disorders that have a similar mutation in at least one of the beta-globin chains of hemoglobin. This results in a change of the hemoglobin to sickle shaped cells when in the deoxygenated state. It is these sickled cells that lead to the symptoms and …
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Physiological and pharmacological factors affecting sickle cell function
Sickle cell disease (SCD) is one of the most common autosomal-recessive genetic disorders affecting millions worldwide. The three most significant abnormal features of RBCs from SCA patients are haemoglobin (HbS) polymerisation, phosphatidylserine (PS) exposure and significantly increased cation …
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Yoga Therapy for Chronic Pain in Sickle Cell Disease
BACKGROUND: Patients with sickle cell disease suffer from both acute and chronic pain that severely affects their quality of life. Acute pain secondary to vaso-occlusive pain crises are a frequent cause of hospitalization and missed days from school and work. Many adult patients also suffer from …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
<p>Sickle cell syndromes increase the risk of rhabdomyolysis, a potentially life-threatening condition stemming from the destruction of skeletal muscle fibers. Acute kidney injury (AKI), a major complication of rhabdomyolysis, contributes to long-term morbidity through the development of chronic …
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Rheological aspects of sickle cell anemia and related hemoglobinopathies
… on patients with the following diseases: normal, sickle cell, sickle cell trait, sickle cell hemoglobin C, homozygous hemoglobin C, sickle cell beta plus thalassemia, and sickle cell beta zero thalassemia. The rheological parameters obtained from a Casson's plot were the apparent yield stress and …
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Healthcare Resource Utilization in Persons with Sickle Cell Disease
… of this study were to determine prevalence of sickle cell disease (SCD) in a Medicaid population, to determine all-cause health care resource utilization and incremental health care resource utilization associated with SCD. An observational database analysis was conducted using information from …
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Mitigation of sickle cell crises using chaos-based analysis
Sickle-cell diseased persons suffer finite pain episodes (luring their lifetime, which are termed sickle cell crises. Using a sickle cell blood flow model, we mathematically demonstrate that the onset of a sickle cell crisis is chaotic. We further show that sickle cell crises may be mitigated by …
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Risking Reproduction: Reproductive Health Among Women With Sickle Cell Disease
<p>Reproductive health among women with sickle cell disease remains a critical gap in the literatures on sickle cell disease, reproductive health, and women's health. Sickle cell disease (SCD) is a condition with a complicated clinical sequelae, accompanied by a myriad of health complications, …
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Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
<p>Sickle cell disease (SCD) is a dangerous condition caused by a genetic mutation on the human beta-globin gene that contributes to erythrocyte sickling, the hallmark of the disease. Previous metabolomics studies have confirmed that elevated sphingosine kinase 1 (SphK1) mediates …
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Sickle Cell Disease Nursing Education: A Mixed Methods Program Evaluation
<p>INTRODUCTION AND BACKGROUND: Sickle cell disease (SCD) is a common disorder of the hemoglobin and affects more than 100,000 people in the United States and millions worldwide. In response to a drastic lack of available education a group of SCD experts developed the Sickle Cell Boot Camp to …
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Novel approach towards pathogenesis and treatment of sickle cell disease
Sickle cell disease (SCD) is one of the most common genetic diseases worldwide. HbS polymerisation causes altered red blood cell (RBC) rheology and fragility, increase in blood viscosity with blockage of small blood vessels, and RBC membrane permeability changes. Excessive levels of cell-free Hb, …
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