Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"SiV"”.
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Assessment of Gamma/Delta T Cell Functionality Following Pathogenic HIV/SIV and Non-Pathogenic SIV Infections
Pathogenic HIV/SIV infection induces high viral loads, aberrant immune activation, and dysfunction in numerous immunologic cells (including gamma/delta (gamma delta ) T cells) leading to opportunistic infections. gamma delta T cells bridge the innate and adaptive immune responses primarily via …
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Signaltransduktion im Gehirn SIV-infizierter Rhesusaffen
… der HIV-Infektion notwendig. Deswegen bietet das SIV/Rhesusaffen-Modell beste Voraussetzungen um die Entstehung der HIV-Demenz genauer zu untersuchen. Es gibt einige Hinweise, dass viele klinische Zeichen der HIV-Demenz mit Veränderungen im dopaminergen System des ZNS einhergehen. In diesem …
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Virus tropism and neutralization response in SIV infection
Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and …
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Charakterisierung der angeborenen Immunantwort in SIV-infizierten Rhesusaffen
… der APOBEC3-Expression auf den Krankheitsverlauf SIV-infizierter Rhesusaffen, dem wichtigsten Tiermodell für AIDS. Dafür wurden die A3G- und A3F-Transkriptionsraten zu verschiedenen Zeiten im Krankheitsverlauf mit real-time-PCR in einigen Zellpopulationen des Blutes sowie in den Zellen der …
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Dissociating Siv Env and Cd4: Consequenes for Virus and Host
… Although CD4-independent variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in the absence of CD4, these viruses typically retain their CD4 binding sites and can still interact with CD4. In this thesis, I present the characterization and evaluation, both in …
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Charakterisierung zellulärer Immunantworten von mit SIV immunisierten und infizierten Makaken
… von Makaken mit dem Affenimmundefizienzvirus (SIV) das wichtigste Tiermodell.In der vorliegenden Arbeit wurden in diesem Tiermodell drei Prime-Boost -Immunisierungsprotokolle, die hinsichtlich der Vektorkombinationen und Applikationsrouten variierten, auf ihre Immunogenität und Wirksamkeit …
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Charakterisierung von Mikrogliafunktionen im Simianen Immundefizienzvirus (SIV) - Rhesusaffentiermodell für AIDS
Rund 60% der HIV-infizierten Patienten sind von neurologischen und psychiatrischen Symptomen betroffen. Die unter dem Begriff HIV-1 assoziierte Demenz zusammengefassten motorischen und kognitiven Einschränkungen, sowie Verhaltsänderungen, lassen sich durch einen signifikanten Funktionsverlust der …
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Novel strategies for characterizing T Cell responses in SIV-infected rhesus monkeys
… HIV is the Simian Immunodeficiency Virus (SIV) - infected rhesus monkey. While HIV research has focused on studying peripheral blood specimens, mucosal sites have recently been identified as a focal point for HIV replication and tissue destruction. They are usually the sites of primary …
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Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
… wurden retrospektiv an einer Kohorte von 37 SIV-infizierten Rhesusaffen mit unterschiedlich schnellen Krankheitsverläufen durchgeführt. Wie bei HIV-infizierten Patienten konnten erhöhte Titer von LPS im Blut der Tiere festgestellt werden. Weder die Messungen der LPS noch die der …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
… HIV infection. Simian immunodeficiency virus (SIV) infection of Rhesus macaques, mimics the disease course of HIV patients and has been used to study HIV pathogenesis and treatment. The goal of this dissertation was to identify a strategy for administering IL-7 to SIV+ anti-retroviral therapy …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… virus (HIV)-1 infection, in which the progressive loss of CD4+ T cells leads to immunodeficiency and opportunistic infection. CD4+ T cell loss is thought to result from direct and indirect killing of CD4 cells in the periphery as well as from pathogenic effects of the virus on the thymus. …
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
… interruption (ATI). Using molecularly barcoded SIVmac239M, we tracked viral clonotypes following ATI in both peripheral blood and tissues at necropsy. Viral rebound appeared to originate by reactivation of a single or a few barcode clonotypes from a limited number of deep lymph nodes or …
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… infected with simian immunodeficiency viruses (SIV) exhibit high plasma viral loads without widespread CD4+ T cell loss. By contrast, non-natural host rhesus macaques experimentally infected with related SIV exhibit high viral loads but display subsequent CD4+ T cell loss and progression to …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… and simian immunodeficiency virus (HIV-1 and SIV)-infection of CD4+ immune cells. We have described the genomic organization of cmklr1 in mouse and analysed the regulatory mechanism behind the corresponding receptor expression. Two transcripts of mouse cmklr1 have been identified, cmklr1a and …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… of macaques with Simian Immunodeficiency Virus (SIV) and correlate these findings with disease progression. To assess the virologic events involving viral entry and spread, macaques were orally inoculated with SIV and necropsied at early times post-infection (days 1 - 14). These studies were the …
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The silicon-vacancy centre in diamond for quantum information processing
… charged silicon-vacancy centre in diamond (SiV$^{−}$) has attracted attention for its very promising optical properties for such a network. In this thesis, we investigate the spin properties of the silicon-vacancy centre as a potential spin-photon interface. First, we use resonant excitation …
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Modelling and analysis of vibrations in flexible cylinders subjected to internal multiphase and external single-phase flows.
… changes causing slug flow-induced vibrations (SIV). Most of the literature related to internal single and two-phase flow has largely focused on the use of a linearised tension beam model. Fundamental understanding of SIV in three-dimensional space and time, considering in-line and axial …
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
… close to half of all vaccinated monkeys from SIV, but questions remain as to the mechanism of protection and whether similar results will be seen in humans against HIV. These questions may be answerable through the use of the cynomolgus macaque monkey model, and a minimally passaged …
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Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population
… transfers of simian immunodeficiency virus (SIV) strains from chimpanzees to human populations produced the current HIV-1 pandemic. We hypothesized that Central African human populations may have been exposed to SIV prior to the current pandemic, and that previous local outbreaks may have …
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Design of Efficient Acoustic Interfaces for Quantum Emitters in Diamond
… interactions with Group IV Silicon vacancy (SiV⁻) centers in diamond. First, we design and simulate a spin-optomechanical interface with ultrasmall mechanical and optical mode volumes ([formula] and [formula], respectively) to interface SiV⁻ centers with a telecom optical mode for quantum …
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