Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"Shuttling"”.
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Current Shuttling Cell Voltage Balancers: Design, Evaluation, and Simulation
Batteries are becoming increasingly important in a variety of applications, including electric vehicles and ships as well as load matching in electric grids. Cell voltage balancers are critical to extracting maximal performance out of batteries and to extending their lifespan. Charge pump balancers …
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Optimizing Ion-Shuttling Operations in Trapped-Ion Quantum Computers
… numerical simulation pipeline of the ion shuttling process. Using these simulation tools, I investigate the leading theories for ion transport and splitting, based on Shortcuts-to-Adiabaticity principles, and extend these methods into two central criteria for optimal ion shuttling. I …
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Dynamic Shuttling of AGO2 to the Nucleus Relieves MicroRNA Repression
The Argonaute (AGO) and the Trinucleotide Repeat Containing 6 (TNRC6) family proteins are the core components of the mammalian microRNA-induced silencing complex (miRISC). This machinery mediates post-transcriptional silencing of mRNA targets by sequence-specific hybridization with microRNAs …
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Shuttling of ions for characterization of a microfabricated ion trap
… trapping and analyze the voltages required for shuttling. Next, the characteristics of a digital-to-analog converter (DAC) are calibrated, and this instrument is integrated into trapping experiments to test the viability of the analytic model. Combining theory with the capabilities of the DAC, I …
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Perpetual Shuttling: An Investigation into Design for Chinese Diasporic Identities in Negotiation
… of the Chinese Canadian diaspora. Perpetual Shuttling is a subjective visual narrative of the Chinese Canadian community of which I am a part. The artifact uses images from my personal archive, which embodies the de-territorializing of Chinese-ness. Perpetual Shuttling expresses the …
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Increasing fermentative butanol production in Clostridium beijerinckii using oxidized extracellular electron shuttling molecules
Continuing concerns over dependence on foreign oil and the environmental impacts of using oil as a major source of fuel have led to increased interest in more sustainable energy options. Bio-butanol, produced during fermentation of plant biomass, is one possible alternative. However, yields for …
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The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
… plays a decisive role for nucleocytoplasmic shuttling of the receptor. Taken together, these results suggest that the shuttling of the C-terminal fragment of c-Met between the cytosol and nucleus appears to be due to the presence of both a putative NLS and an NES in the juxtamembrane region.
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Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
… between the nucleus and the cytoplasm, and this shuttling is required for its cytoplasmic signaling. I have further investigated the regulation and function of mTOR cytoplasmic-nuclear shuttling. A systematic screen of mTOR revealed a rev-like NES sequence within mTOR at amino acids 1281--1289, …
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Extracellular Electron Shuttle Mediated Biodegradation of Hexahydro-1,3,5-trinitro-1,3,5-triazine
… The potential use of extracellular electron shuttling compounds to mediate electron transfer between iron (hydr)oxides and Fe(III)-reducing microorganisms was investigated for decontaminating RDX. The ultimate goal of this study is to develop an optimal strategy for the biodegradation of …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… it snaps back to the 3’ end, restarting another shuttling cycle. We investigated the mechanism of repetitive shuttling and discovered the same behavior on various DNA substrates. We concluded that the repetitions are induced by the lack of ssDNA track ahead of the Rep. Using the repetitive …
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Exploration of helicase mechanisms at single molecule level: answering decades old questions and bioengineering super proteins
… it snaps back to the 3’ end, restarting another shuttling cycle. We investigated the mechanism of repetitive shuttling and discovered the same behavior on various DNA substrates. We concluded that the repetitions are induced by the lack of ssDNA track ahead of the Rep. Using the repetitive …
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Regulation of PPARgamma Activity by mTOR in Adipogenesis
… signaling, which involves cytoplasmic-nuclear shuttling of mTOR. As direct evidence, data show that leptomycin B (LMB), a specific inhibitor of nuclear export receptor Crm1 confers the accumulation of nuclear mTOR. Further investigation by altering mTOR's nuclear shuttling activity with …
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Developing Structure-Activity-Relationships for Metal-Ligand-Cooperative (MLC) Complexes using PR2NR′2 Ligands
… ligands with Ru gave a series of MLC proton shuttling complexes for catalytic testing. From catalytic performance, structure-activity relationships were extracted for two types of reactions that exploit a proton shuttling relay: 1) the intramolecular cyclization of ethynyl amine and alcohol …
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Exploring new reactions with Organic Electron Donors and the complexities of the Birch reduction
… reductively cleaved via intramolecular electron-shuttling instead of the more conventional through-bond electron transfer. This mode of reduction by SED is not well-explored. To this end, several ester and amide-based substrates were synthesised in an attempt to expand the scope of this …
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Molecular Mechanism of Insulin Resistance: Role of mTOR Signaling Pathways
… regulated by a nucleocytoplasmic shuttling signal. The loss of nuclear import was accompanied by the significantly reduced ability of the L545A/L547A mutant to activate S6K1 in cells. Most importantly, when nuclear import was restored in the L545A/L547A mutant by the addition of an …
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Amperometric biosensor systems prepared on poly (aniline-ferrocenium hexafluorophosphate) composites doped with poly(vinyl sulfonic acid sodium salt)
… exhibiting electrochemistry in non acidic media; shuttling electrons between HRP and GCE for biosensor applications.
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Regulated Subcellular Distribution of Constitutive Androstane Receptor (Car)
… with a model in which CAR is constantly shuttling between the cytoplasmic and the nucleus with the steady state strongly favoring cytoplasmic localization in untreated animals and strongly favoring nuclear localization in PB-treated animals. Regulation of the subcellular distribution of …
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Extracellular Electron Shuttle Mediated Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine
… The potential use of extracellular electron shuttling compounds to mediate electron transfer between iron (hydr)oxides and Fe(III)-reducing microorganisms was investigated for decontaminating RDX. The ultimate goal of this study is to develop an optimal strategy for the biodegradation of …
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Characterization of zebrafish zipper-interacting protein kinase
… and zebrafish ZIPK underwent nucleocytoplasmic shuttling without PAR-4 interaction, unlike rodent ZIPK, which required PAR-4 for nuclear exit. Unlike human ZIPK, zebrafish ZIPK TT299/300AA mutants were able to undergo shuttling. Similar to human ZIPK, catalytic mutations to zebrafish ZIPK …
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