Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Short-bowel syndrome"”.
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
Short-bowel syndrome (SBS) is a costly condition primarily affecting very low birth weight, premature infants with long-term detriment to nutritional adequacy and quality of life. Necrotizing enterocolitis (NEC) -the primary cause of surgical resection leading to pediatric SBS- has an ill-defined …
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The effect of butyrate-supplemented total parenteral nutrition on muc2 mRNA and goblet cell chemotypes in a short bowel syndrome neonatal piglet model
… translocation are common complications of short bowel syndrome (SBS) and parenteral nutrition (PN). Although mucins help prevent intestinal bacteria translocation, total mucin production has been shown to decrease during PN infusion. Butyrate administration may be a mucin fortifying …
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Autologous intestinal lengthening procedures for short bowel syndrome. A systematic review of clinical effectiveness and an assessment of their utility for adult and paediatric patients with intestinal failure in the UK
Introduction:Short bowel syndrome (SBS) results from surgical resection, congenital defector disease-associated loss of absorption and is characterized by the inabilityto maintain protein-energy, fluid, electrolyte or micronutrient balances whenon a conventionally accepted, normal diet 1 . In order …
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BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE
… the tract including cancer, gastroparesis, short bowel syndrome and Hirschsprung’s disease. Other diseases of the gut involve segments along with their adjacent sphincters. The most common treatment in all these conditions requires surgical resections of the diseased segment which results in …
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Experiences of adult patients living with home parenteral nutrition: a grounded theory study. A qualitative research into the experiences of home parenteral nutrition: discovery of patients’ perspectives.
… malabsorption and malnutrition associated with short bowel syndrome (SBS). Home parenteral nutrition (HPN) became available to treat these patients since the 1970s. There is a paucity of qualitative research on patients’ experiences in the UK. The study aim was to generate theory that explains …
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Antibiotic resistance in the gut microbiota
… studies, we investigated the effects of short bowel syndrome on infant gut microbiota, the immune system and bile acid metabolism. We also sequenced the microbiota of the human vermiform appendix, highlighting its complexity. Finally, this thesis demonstrated the strain specific nature of …
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Short-Chain Fatty Acids and Functional Adaptations in the Neonatal Intestine
… to compensate for reduced absorptive capacity. Short-chain fatty acids (SCFA) are known to enhance this adaptive process in adult animal models, and data from our lab indicates that butyrate (Bu) results in marked changes in glucose transport in the intestine within minutes. We hypothesized that …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… GLUT2 from the basolateral to the BBM. Systemic short-chain fatty acids and dietary fiber are reported to stimulate the secretion of GLP-2. Therefore, we supplemented TPN with butyrate and found increases in structural adaptation. The most marked effects were in the intestinal epithelium, with …
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Generation and use of new tools for the characterisation of gut hormone receptors
… analogue of GLP-2 is used for the treatment of short bowel syndrome. A common missense mutation in the GLP-2 receptor (GLP2R), D470N, has been found to be associated with type 2 diabetes, and here we sought to understand the mechanism underlying this association. The D470N mutant has decreased …
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Kurzdarmsyndrom - eine Analyse bei 26 Patienten und Nachuntersuchungen an einem Teilkollektiv
Das Kurzdarmsyndrom ist ein seltenes Krankheitsbild, das als Folge ausgedehnter Dünndarmresektionen entsteht. Seine Inzidenz liegt bei 0,1-0,2/100.000 Einwohner. In der Häufigkeitsstatistik bei Erwachsenen dominieren heutzutage der Morbus Crohn sowie Mesenterialinfarkte als Ursache für ausgedehnte …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… intestinal diseases, including celiac disease, short bowel syndrome (SBS), necrotizing enterocolitis (NEC), and the inflammatory bowel diseases, Crohn’s disease and ulcerative colitis, contribute to malabsorption. The treatment of severe malabsorption often requires medical nutrition support …