Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Short linear motifs"”.
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Developing a Contextual Annotation Framework for Short Linear Motifs in Proteins
Identifying and validating short linear motifs (SLiMs) is challenging due to their low sequence complexity and high prevalence across the proteome. Many false positives—sequences that match the pattern of the SLiM but are not involved in the biological functions typically associated with …
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How codon choice determines evolvability and evolutionary robustness in short linear motifs
Short linear motifs, made up of 2-10 amino acids in linear sequence space, are a central component of cellular decision making through proteins. They form a modular system in cells where combinations of domains and motifs are used as basic functional building blocks through interactions. Functions …
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Harnessing the Anaphase-Promoting Complex for Targeted Protein Degradation
… APC/C substrates contain multiple copies of short linear motifs (SLiMs), termed degrons, that serve as APC/C-recognition sequences. My research approach involved systematically dissecting various combinations of degrons from natural APC/C substrates, primarily using cell-based degradation …
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How short, degenerate motifs across the human proteome recognize the actin remodeling factor ENAH
… interactomes are those that occur between short linear motifs (SLiMs) and structured domains. SLiMs are stretches of 3-10 residues found in intrinsically disordered regions of proteins. Given their degeneracy, short length, and weak affinities, it is not immediately clear how such low …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… well-characterized TRP, TRP120, uses multiple short linear motifs (SLiMs) to interact with host proteins and co-opt signaling axes to inhibit apoptosis. Interestingly, other ehrlichial TRPs have been shown to interact with a diverse array of host proteins and harbor predicted SLiM sequences …
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Determining the Molecular Underpinnings of Iron Homeostasis in Human Cells
… these proteins. I found that NCOA4 bears two short linear motifs that each bind to GATE16 with weak affinity. However, these binding motifs are highly avid and, in concert, support high-affinity binding of NCOA4 to oligomerized GATE16. I further describe that ferritin degradation in cultured …
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Elaboration of the Homer1 Recognition Landscape Reveals Incomplete Divergence of Paralogous EVH1 Domains
… identify interactions mediated by these Short Linear Motifs (SLiMs) is instrumental to unraveling the many biological processes regulated by this class of interactions. Characterizing the binding preferences of specific SLiM binding domains is key to both predicting interactions and …
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Predicting motif mimicry in viruses
… (DMI) between a globular domain and a short linear motif (SLiM) in its partner. Advances in high-throughput experimental techniques have been applied at large-scale in an attempt to characterise the interactomes of various organisms. However, the PPI networks identified by these …
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Biochemical and functional characterization of human RNA binding proteins
… RBPs bound an unexpectedly low diversity of RNA motifs, implying convergence of binding specificity toward a small set of RNA motifs characterized by low compositional complexity. Offsetting the low diversity of sequence motifs, extensive preferences for contextual features beyond short linear …
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The NTF2L Domain Is a Date Hub That Interacts with SLiMs to Regulate Assembly of Stress Granules
… networks that drive biomolecular condensation. Short linear motifs (SLiMs) are the most abundant functional unit involved in protein-protein interactions (PPIs). The interactions between SLiMs and date hubs are crucial for various cellular processes. While SLiMs and date hubs are prevalent in …
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
… outside mitosis, and examining the role of Short Linear motifs (SLiMs) within AURKA N-terminal domain in regulating its stability and activity. I show that the previously known D-box-like motif (R371xxL374) within C-terminal is not a functional degron. I also reveal that the A-box motif may …
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
… formation in cells. Using protein domain and short linear motif (SLiMs) deletion mutants, we demonstrated that SMAUG1 phase separation is driven by its structured ‘Smaug similarity region 1’ (SSR1) dimerization domain and a novel intrinsically disordered prion-like domain. In contrast, the …
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Organised Chaos: defining different degrees of intrinsic disorder by molecular dynamics methods
… and signalling functions, such as p53 and short linear motifs (SLiMs)-containing regions. Trying to understand the relationships between structure and functions in these highly flexible and dynamic systems is rather challenging, because their intrinsic flexibility makes them extremely …