Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"Short chain fatty acids"”.
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On-trap derivatization of short-chain fatty acids
… modulate immune response by the production of short-chain fatty acids (SCFAs). There is a need for rapid, selective analytical methodology capable of trace analysis of SCFAs in complex biological matrices. Previous studies by others using multibed-sorbent traps, solid phase microextraction …
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Short-Chain Fatty Acids and Functional Adaptations in the Neonatal Intestine
… to compensate for reduced absorptive capacity. Short-chain fatty acids (SCFA) are known to enhance this adaptive process in adult animal models, and data from our lab indicates that butyrate (Bu) results in marked changes in glucose transport in the intestine within minutes. We hypothesized that …
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The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… and abroad. Dietary fiber is fermented into short-chain fatty acids (SCFAs) by the gut microbiota and is vital to proper gut function. Previous studies have found that diets lacking fiber, SCFAs, or receptors for SCFAs predispose both animals and humans to IBD and colorectal cancer. However, …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… in the host. Intestinal microbiota produce short chain fatty acids (SCFAs) via dietary fiber fermentation. SCFAs have profound effects on the immune system. We investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell …
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Quantification of short-chain fatty acids in cecal material by gas chromatography-mass spectrometry
… colon that produce C<sub>2</sub> – C<sub>4</sub> short chain fatty acids (SCFA) and <em>Lactobacillus</em> species that produce lactate in addition to SCFAs are known to have positive health benefits. These organic acids were extracted with ether from murine cecal material (from Dr. Gary …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… GLUT2 from the basolateral to the BBM. Systemic short-chain fatty acids and dietary fiber are reported to stimulate the secretion of GLP-2. Therefore, we supplemented TPN with butyrate and found increases in structural adaptation. The most marked effects were in the intestinal epithelium, with …
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Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
… dietary fibres. In this process, they produce short chain fatty acids (SCFAs) such as butyrate, an important energy source for intestinal epithelial cells. SCFAs are chemically related to histone acylations, a growing number of post-translational modifications that include histone acetylation, …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… ferment the polysaccharides to produce short chain fatty acids (SCFAs). SCFAs constitute around 70% of the energy source in ruminants and 10-15% in non-ruminants. Recently, SCFAs have been shown to be ligands fortwo G protein-coupled receptors (GPCRs), Gpr41 and Gpr43. We show that Gpr41 …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… significant advancement in the production of short chain carboxylic acids during bacterial fermentation is described. This work offers new insights into carboxylic acid toxicity and methods for improvement of microbial tolerance that is important for improving productivity, titer, and yields …
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Characterization of short chain fatty acids in microbial cultures by DART-MS and GC-MS
… of starch and other carbon sources produces short-chain fatty acids (SCFA) such as butyrate and lactate, which are important in human health and disease. Analysis of the results of mono- and co-cultures in in vitro systems has led to the conclusion that diverse microbial organisms may each …
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In Vitro Analysis of Short Chain Fatty Acids and Human Fecal Microbiota Stimulated by Pectin Sources
<p>As interest increases for colonic health, various studies have been conducted to investigate functional ingredients for host health and prevention of chronic disease in humans such as colon cancer and Type 2 diabetes. In particular dietary fiber has been reported to have beneficial effects on …
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Quroum sensing disruption and the use of short-chain fatty acids and polyhydroxyalkanoates to control luminescent vibriosis
… part of this work describes the application of short-chain fatty acids and polyhydroxyalkanoates. First, it was shown that formic, acetatic, propionic, butyric and valeric acid inhibit growth of luminescent vibrios in vitro in a pH-dependent way. Furthermore, the addition of 20 mM of the …
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SHORT-CHAIN FATTY ACIDS INDUCED AUTOPHAGY SERVES AS AN ADAPTIVE STRATEGY FOR RETARDING MITOCHONDRIA-MEDIATED APOPTOTIC CELL DEATH
Short-chain fatty acids are the major by-products of bacterial fermentation of undigested dietary fibers in human large intestine. SCFAs, mostly propionate and butyrate, inhibit proliferation and induce apoptosis in colon cancer cells, but clinical trials had mixed results regarding the anti-tumor …
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The Modulating Effects of Dietary Fiber and Short-Chain Fatty Acids on Enterocyte Differentiation, Maturation and Turkey Coronavirus Infection
… maturation of enterocytes is the availability of short-chain fatty acids (SCFA) in the intestinal lumen. These compounds are by-products of the bacterial fermentation of dietary fiber and serve as the primary energy source for enterocyte metabolism. The overall objective of this dissertation was …
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Optimization and Application of Metabolomic Assays for Analyzing Diet-induced and Gut Microbiota-derived Short-chain Fatty Acids in Mice and Humans
… optimize a metabolomic assay to quantify fecal short chain fatty acids (SCFAs), a byproduct of microbial fermentation in the gut, and to apply this assay to health outcomes of RS4 intervention in an adult population with MetS as well as genetically induced obese mice. <strong>Methods:</strong> …
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Mechanistic insight into the role of dietary fibers and short chain fatty acids in the regulation of metabolism and inflammation in the pig
… microbial community structure and production of short chain fatty acids (SCFA). A series of in vivo experiments were conducted to determine the effects of dietary fiber on pig growth performance and gut microbial community as well as host metabolism. In the first study, a comparison between …
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Development of a headspace solid-phase microextraction (HS-SPME) procedure for the determination of short-chain fatty acids (SCFAs) in activated sludge by GC-FID
… is added into the wastewater treatment system. Short-chain fatty acids (SCFAs), an energy source of the bioorganisms, are produced during activated sludge digestion, and play a significant role in phosphorus and nitrogen removal as well as the removal of organic materials during the process of …
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Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… virulence. In this thesis, I describe how fatty acids, derived from both gut microbiota and diet, contribute to attenuation of virulence of enteric pathogen Salmonella. In Chapter 1, I review how dietary and microbiota metabolites affect different aspects of host-microbe interactions. These …
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The biodegradation of valeric, butyric, propionic and acetic acids in anoxic, subsurface, soil environments
… by monitoring the biodegradation of short-chain fatty acids in anaerobic soil microcosms. Valerate, butyrate, propionate, and acetate concentrations were monitored independently using separate microcosms. The effect of sulfate on the microbial communities was also investigated. One …
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Sample Preparation/Concentration for Trace Analysis in GC/MS (A study of solid phase microextraction and headspace sampling)
… Trace amounts of Veltol ®, Veltol Plus® and short chain fatty acids in food samples were analyzed by GC/MS. Since SPME is not directly applicable to solid samples, SPME associated with MAE techniques was studied for solids, primarily food samples. The efficiency of classical solvent …
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