Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Shock and kill"”.
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The impact of heptose phosphates on HIV latency and human immune responses
… agents (ARTs) achieves total control of viremia and prevents progression of HIV to AIDS, but they are not a cure. Shock-and-kill therapy aims to use HIV latency reversal agents to promote clearance of HIV infected CD4 T-cells that make up the HIV reservoir to achieve drug-free remission from HIV. …
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Cell intrinsic innate immunity protein RPRD2 restricts transcription from the HIV-1 LTR in human cell lines
… therapy is never curative. The establishment and persistence of latency are complex and still incompletely characterised. Host factors that repress retroviral transcription are thought to be involved in this phenomenon. RPRD2 was identified as an antiviral protein that restricts HIV …
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Development of a Lentivirus-mediated Gene Therapy Targeting HIV-1 RNA to Eliminate Infected Cells
… agent of acquired immunodeficiency syndrome and the cause of over 40.1 million deaths. The latent HIV-1 reservoir is the major roadblock to cure and necessitates lifelong antiretroviral therapy (ART), which is vulnerable to drug resistance. I contributed towards the development of a novel …
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Platinum and palladium complexes as human immunodeficiency virus latency reversal agents
The Persistence of latent HIV-1 provirus and reservoirs presents a formidable challenge in human immunodeficiency virus (HIV/AIDS), numerous efforts have been made to develop vaccines and chemotherapeutic agents. However, an effective vaccine remains elusive, and existing HIV/AIDS medications do …
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Understanding and Exploiting Viral Protein US28 During Human Cytomegalovirus Latency
… individuals, but is a serious cause of mortality and morbidity in the immunocompromised and in neonates. Like other herpesviruses, HCMV establishes latency in specific cell types following primary infection, and reactivates periodically during the lifetime of the host. One important site of HCMV …