Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Shigella"”.
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Enterobacterial Common Antigen Biosynthesis in Shigella flexneri
… thesis was to investigate ECA biosynthesis in Shigella flexneri, with particular focus on WzyE, the Wzy protein from ECA biosynthesis. For the first time, a WzyE protein was directly investigated and the data showed that WzyE is uncharacteristic of other Wzy proteins; showing a high amount of …
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Shigella Boydii 18: Characterization and Biofilm Formation
Shigella boydii 18 Chicago Department of Public Health (CDPH) was the cause of a foodborne outbreak involving bean salad. The S. boydii CDPH strain was found to be more acid tolerant than the S. boydii ATCC (American Type Culture Collection) type strain in tryptic soy broth acidified with glacial …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
The Gram-negative bacterium Shigella flexneri is the causative agent of Shigellosis, also known as bacillary dysentery, responsible for 5-15% of the global burden of diarrhoeal disease. Despite over 50 years of Shigellosis research, the search for a commercially viable vaccine is ongoing. A …
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Characterization of novel virulence factors of Shigella flexneri and development of Caenorhabditis elegans as an animal model for Shigella infection
The Gram-negative bacterium Shigella flexneri is the causative agent of Shigellosis, also known as bacillary dysentery, responsible for 5-15% of the global burden of diarrhoeal disease. Despite over 50 years of Shigellosis research, the search for a commercially viable vaccine is ongoing. A …
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Blocking antigens of Shigella alkalescens and its variants
Thesis (M.S.)--Michigan State College of Agriculture and Applied Science. Dept. of Bacteriology, 1947
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Coliforms, Salmonella, and Shigella in the James River Basin
… were used for the detection of Salmonella and Shigella. Biochemical tests were used to identify the non-lactose-fermenting enteric bacteria and evaluate which lactose non-fermenting bacteria were most often isolated during each month. The median fecal coliform levels for 3 locations were above …
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Towards the Synthesis of the Unusual Monosaccharides Found in the Shigella sonnei O-Antigen and Analysis of Shigella flexneri 2a Glycoconjugate Vaccine Samples
… by the Gram-negative bacteria belonging to the Shigella species. Despite over 60 years of vaccine research, no licensed vaccine to prevent shigellosis is commercially available. Bioconjugate vaccines based on the O-antigen against various Shigella serotypes are under development. Shigella sonnei …
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Factors influencing the growth of Shigella dysenteriae on laboratory media
Thesis (M.S.)--Michigan State College of Agriculture and Applied Science, 1942
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Polarity and secretion of Shigella flexneri IcsA: a classical autotransporter
… virulence factor for the enteropathogen Shigella flexneri as it provides adherence properties and allows intra- and intercellular spreading in the colonic mucosa. IcsA is an outer membrane surface protein that specifically hijacks host-cell actin recruiting and polymerising complexes …
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The Biogenesis and Homeostasis of the Shigella flexneri Cell Envelope
Shigella flexneri is a significant cause of gastroenteric disease in the developing world, predominantly devastating the paediatric age group. This bacterial pathogen synthesises a plethora of polysaccharide-based complexes on its cell surface, such as lipopolysaccharide (LPS), that facilitate host …
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Characterizing induced gene expression in Shigella flexneri following bile salt exposure
The Shigella species cause millions of cases of watery or bloody diarrhea each year in developing countries, with children under the age of five years most vulnerable to infection. Emerging strains of multidrug resistant Shigella emphasize the need for a comprehensive and cost-efficient vaccine; …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
Shigella flexneri is a highly adapted pathogen that invades the host cytosol and causes bacillary dysentery. Shigella has evolved powerful countermeasures to disarm host defense mechanisms; amongst them a family of twelve bacterial E3 ubiquitin ligases (IpaH) that are structurally unrelated to …
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An immunological comparison of animal-grown and broth-grown shigella flexneri types lb and 3
… following recovery from this disease. However, shigella vaccines made from in vitro-grown organisms did not increase resistance to dysentery. The purpose of the present investigation was to determine whether or not Shigella flexneri produced antigens in the in vivo environment formed by …
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Efficacy of Detergent Rinse Agents to Remove Salmonella and Shigella spp. from the Surface of Fresh Produce
… 4 LOG CFU/ml of Salmonella, and 3-LOG CFU/ml Shigella were recovered, with slightly lower recovery from tomatoes. Inoculated strawberries rinsed with SLS, displayed minimal recovery at ~1.5-LOG CFU/ml at 22°C, and <1-LOG CFU/ml at 40°C. When whole strawberries treated with SLS were analyzed, …
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Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
Shigella spp. remain a notorious and dominant threat to public health, mainly affecting children and with increasing multidrug resistance. Vaccines represent a significant preventive measure against infectious diseases; however, no approved vaccines are currently available to protect against …
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Identification of host factors required for cytosol entry by Shigella flexneri: Results of a genome-wide CRISPR/Cas9 screen
The Gram-negative bacterial pathogen *Shigella flexneri* remains a globally significant cause of morbidity and mortality. *Shigella* induces its uptake into colonic epithelial cells via a short-lived vacuole, and lyses the vacuole membrane to gain entry to the host cytosol. As a professional …
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
Many Gram-negative bacterial pathogens such as Shigella and adhesive invasive Escherichia coli (AIEC) cause infections characteristic of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative …
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