Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Shiga toxin"”.
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Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition
Infection with Shiga toxin-producing bacteria can place patients at risk of developing hemolytic uremic syndrome, a toxemic condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Though hemolytic uremic syndrome remains the leading cause of acute renal failure in …
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Untersuchungen zur Regulation von Shiga-Toxin 2 und zur Attenuierung von enterohämorrhagischen Escherichia coli
… Virulenzfaktoren dieser Pathogene sind Shiga-Toxine (Stx) und Faktoren, die an der Ausprägung der sog. "attaching and effacing"-Läsionen auf Darmepithelzellen beteiligt sind. Vor allem Kinder und ältere Menschen sind von den Infektionen, die häufig in Form von Ausbrüchen auftreten, …
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The hemolytic uremic syndrome in childhood. A focus on Shiga toxin and its consequences
Contains fulltext : 250224.pdf (Publisher’s version ) (Open Access)
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Molekularbiologische Charakterisierung Shiga Toxin 1-konvertierender Bakteriophagen und des phagenkodierten Typ III Effektorproteins NleA4795
Shiga Toxin (Stx)-konvertierende Bakteriophagen besitzen eine konservierte lambdo-ide Genomstruktur, weisen aber ein hohes Maß an genetischer Diversität auf. Aus diesem Grund wurden die bereits vorhandenen Sequenzdaten der Stx1-Phagen CP-1639 des Escherichia coli O111:H- Stammes 1639/77 und BP-4795 …
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Charakterisierung und Antibiotika-Resistenzprofil von Shiga Toxin-produzierenden Escherichia coli Isolaten von Patienten und Ausscheidern
… vermuten. Die Tatsache, daß über 12 Prozent Shigatoxin produzierender E. coli Stämme aus humanen Stuhlproben Antibiotikaresistenzen aufweisen, hat klinische und epidemiologische Bedeutung. Resistente STEC-Stämme hätten einen selektiven Vorteil gegenüber anderen koliformen Bakterien in …
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Modeling for thermal resistance of non-O157 shiga toxin producing Escherichia coli in ground beef
… a predictive inactivation model for non-O157 shiga toxin producing <em>Escherichia coli</em> (STEC) in ground beef was developed. Six strains of non-O157 STEC; <em>E. coli</em> O26:H1, <em>E. coli</em> O45:H2, <em>E. coli</em> O103:H2, <em>E. coli </em>O111:H8, <em>E. coli</em> O121:H9, and …
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One Health-One City; the extent of Shiga-toxin producing Escherichia coli in Cape Town
The estimated global burden of STEC (Shiga toxin producing Escherichia coli) is 2,481,511 illnesses, 269 deaths, and 26,827 DALYs with 48% of these being foodborne. This thesis provides information on STEC diagnostic strategy, undetected STEC in a tertiary referral hospital in Cape Town, and the …
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Integrating Spatial and Temporal Methods Into Surveillance for Shiga Toxin Producing Escherichia Coli (Stec) O157:H7 in Illinois
Temporal and spatial clustering was identified for sporadic cases. Temporal patterns showed an increase in cases from late spring to early fall annually. Areas of decreased risk were found in the southern third of the state and the most urban areas surrounding Chicago. Risk factors associated with …
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Genomische Unterschiede zwischen Shiga Toxin-Produzierenden Escherichia coli (STEC) O157:H7 und Sorbitol Fermentierenden (SF) STEC O157:H- -Stämmen
Sorbitol fermentierende (SF) Shiga Toxin-Produzierende Escherichia coli (STEC)-Stämme des Serotyps O157:H- stellen bedeutsame Auslöser für Durchfallerkrankungen und des lebensbedrohlichen Hämolytisch-Urämischen Syndroms (HUS) in Mitteleuropa dar. Die Virulenzfaktoren und Krankheitsbilder solcher …
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Development of 11-plex assay for the rapid screening of samples for detection of Shiga toxin-producing E. coli
Shiga toxin-producing Escherichia coli (STEC) have been identified by the USDA as a serious threat to the nations health stemming from contaminations in the food supply, specifically, the beef chain. I have developed an assay that is able to screen samples for STEC in a rapid and multiplexed …
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Characterization of Shiga-toxin Producing Escherichia coli Infections and Cryptosporidiosis in South Dakota with Respect to Animal Exposures, 2012
<p>Shiga-toxin producing strains of <em>Escherichia coli</em> (STEC) and <em>Cryptosporidium</em> spp. are significant causes of illness in humans. Incidence rates of these illnesses are higher in South Dakota than in the United States as a whole. Transmission of these agents to people through …
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Shiga Toxin-Producing Escherichia coli: a Public Health Challenge in the Pre-Harvest Stage of the Farm-to-Table Continuum
… cattle. While most strains are commensal, Shiga toxin-producing E. coli (STEC) can cause severe human illness. Pathogenicity of STEC is associated with genes such as those encoding Shiga toxins, enterohemolysin, and intimin. By targeting these genes, highly sensitive molecular-based …
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Beschreibung und Charakterisierung einer neuen Pathogenitätsinsel, integriert in das selC-Gen von "Locus of enterocyte effacement"-negativen, Shiga-Toxin-produzierenden Escherichia coli
Shiga Toxin-produzierende Escherichia coli (STEC) verursachen Diarrhöen und hämorrhagische Colitis. Als lebensbedrohliche Komplikation können sie ein hämolytisch-urämisches Syndrom auslösen. Bisher identifizierte Virulenz-faktoren der STEC sind auf Bakteriophagen, Plasmiden und Pathogenitätsinseln …
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Effects of low molecular weight compounds on growth, virulence gene expression and cytotoxic activity of Shiga toxin-producing Escherichia coli O157:H7
… OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Shiga toxin-producing Escherichia coli (STEC) infections are clinically associated with hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), and are the leading cause of acute renal failure in children. A series of novel low molecular …
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Isolation And Molecular Characterization Of Shiga Toxin Producing Escherichia coli In Cattle, Water And Diarrhoeal Children From The Pastoral Systems Of Southwestern Uganda
… STEC-contaminated water. The production of Shiga toxin (Stx) investigated using Duopath Verotoxin detection kits showed that a majority of STEC from di erent sources produced Stx1 or Stx2 or both Stx. Using PCR or PCR-RFLP assays, stx2 and eae gene types were analysed. Variant stx2 vhc was …
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Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
… (intracellular cell spreading protein) Stx1A (Shiga toxin 1 subunit A), Stx2A (Shiga toxin 2 subunit A) and StxB (Shiga toxin subunit B). Upon intramuscular administration, multivalent antibodies were induced and achieved broad neutralization of various Shigella serotypes invasion and …
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Jautienoje aptiktų Šiga toksiną išskiriančių Escherichia coli identifikavimas ir genominė analizė /
Shiga toxin-producing Escherichia coli (STEC) is one of the most common foodborne pathogens, characterized by the synthesis of Stx1 and/or Stx2 toxins. STEC is associated with numerous human diseases worldwide, ranging from mild diarrhea to hemorrhagic colitis (HC), hemolytic uremic syndrome (HUS) …
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MOL-PCR For SNP Based Detection and Characterization of STEC non-O157 Strains
Shiga toxin-producing Escherichia coli (STEC) strains are important food-borne pathogens that have been linked to human illness. In the United States, STEC O157:H7 strains have been attributed to the majority of disease and outbreaks; however, the frequency of disease associated with STEC non-O157 …
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Surface Directed Monoclonal Antibodies against STEC Aid in the Reduction of Pathogen Detection Times from Food and Water
… Food Inspection Agency for the detection of Shiga toxin producing E. coli (STEC) are time consuming and tedious, taking up to 5 days before a positive sample can be confirmed. The goal of this project was to streamline the detection procedure for serogroup O157 and 6 important non-O157 …
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