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Showing 1 to 20 of 80 for “"Shh"”.
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SUFU in SHH signalling mediated myogenesis
… Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, less is known regarding the pathways operation during cell differentiation and whether Suppressor of Fused (SUFU), the protein inhibitor of …
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Evolution of the ZRS and the Regulation of SHH Expression in the Forelimbs of Bats.
The characterisation of sonic hedgehog (Shh) in the developing limbs of the two bat species Miniopterus natalensis and Carollia perspicillata showed that Shh expression pattern was different from that observed in mouse limbs. An interesting discovery was that bat embryos display a second round of …
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Shh... there's some racism in these policies: a phenomenological study of Black student experiences with on-campus housing policies
Black students are called to live on campus and promised a better college experience by doing so. However, when Black students move on campus, they continue to experience hostile environments and microaggressions from those around them. Black students not only experience these microaggressions, but …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… in adult pituitary and in pituitary tumors. Shh is a signaling protein, important in regulating patterning and proliferation in the embryo and the adult. It has a crucial role in pituitary development and Shh deficient mice do not even have a rudimentary Rathke's pouch (the development …
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Role of Sonic Hedgehog in Development of the Central Nervous System
Sonic hedgehog (Shh) functions as a morphogen to induce early dorso-ventral patterning of the central nervous system (CNS) and specifies cell fates of spinal motor neurons. Shh has also been known to promote cell cycle progression of embryonic stem cells as well as adult neural stem/progenitor …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
Sonic hedgehog (Shh) is a member of the hedgehog family of signalling molecules and secreted from two signalling centers, the notochord and the floor plate, where it functions as a morphogen to induce early dorso-ventral patterning of the cenral nervous system (CNS). More recently, multiple actions …
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The Role of Sonic Hedgehog in the Hypothalamus
… E. Zevallos Douglas J. Epstein Sonic hedgehog (Shh) is a morphogen secreted during early development that is required for the formation of the ventral neural tube, including the ventral forebrain. The prechordal source of Shh underlying the forebrain is required early to bifurcate the cerebral …
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Astrocytic Sonic Hedgehog signalling in development and disease
Sonic hedgehog (Shh) signalling is a critical pathway in embryonic development, with known roles in cell differentiation, tissue patterning, and the establishment of body axes (Rowitch et al., 1999; Echelard et al., 1993; Ericson et al., 1997; Jessel and Lumsden, 1997). Beyond these canonical …
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Specification of Stem Cells and Niche During Hair Follicle Morphogenesis
… I investigated the signaling patterns of SHH, previously suggested to regulate Sox9 expression. Interestingly, while Shh was expressed exclusively by the WNT<sup>high</sup> basal cells, SHH signaling was primarily detected in the suprabasal SOX9+ cells. By inducing the expression of …
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Investigating the chromatin dynamics of gene activation
… is tightly controlled. Sonic hedgehog (Shh) is an important signalling protein which is vital for the patterning of the embryo. Shh is expressed throughout the developing central nervous system, gut and the posterior limb bud. This complex pattern of expression is regulated by the …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… such a pattern ventrally is tightly regulated by Shh morphogen, released by cells of organising centres in the ventral midline of the embryo, namely the floor plate and the notochord. In recent years, a lot of research has been carried out to understand how cells interpret the Shh signal and …
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Dynamic visualization and genetic determinants of Sonic hedgehog protein distribution during zebrafish embryonic development
… of the vertebrate Hh homolog, Sonic Hedgehog (Shh) in developing zebrafish embryos. By fluorescently tagging Shh proteins, I found that these localize to discrete punctate structures at the membranes of expressing cells. These were often regions from which filopodial protrusions emanated from …
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Mechanisms and Targeting of Neurodevelopmental Regulator Rest In Medulloblastoma Dissemination
… four subgroups: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4. While patients with WNT tumors have the best prognosis, patients with SHH tumors have a more variable prognosis concurrent with metastatic disease. This subset of SHH patients have elevated levels of the neurogenic …
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Limbs gone batty : the role of the anterior-posterior patterning signal, Sonic Hedgehog, in the development of the unique bat limb
… patterning signal, Sonic hedgehog (Shh), and its downstream target, Patched 1 (PtcJ), have contributed to the development of the unique bat limb. The embryonic development of Miniopterus natalensis (Miniopteridae) is described for the first time and the expression patterns of Shh and …
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Targeting c-met in sonic hedgehog medulloblastomas
… subgroups: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4. Although the 70-75% of MB patients survive the disease, the current therapeutic regimen, which comprises surgical resection, chemotherapy and cranial irradiation, is worryingly associated with severe side effects in these …
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Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… led to the up-regulation of sonic hedgehog (Shh) both at the mRNA and protein levels causing activation of hedgehog signaling. These results were also reproduced in another NSCLC cell line (H2030), and these results were further associated with the induction of EMT phenotype. Induction of EMT …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the ventral telencephalon (vTel), through diffusion to form a concentration gradient. Strikingly, when Pax6 is deleted, a subset of cortical progenitor cells that would normally become glutamatergic commit into a …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… several pro-oncogenic signalling pathways (Wnt, Shh, PDGF, Ras, etc.). Specifically, expression of the Wnt ligands and (¿-catenin/Lef1 markedly increased at the initiation stage of tumour formation. In contrast, expression of components of the Shh pathway was markedly increased in the fully …
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
… (ZPA). The secreted molecule, sonic hedgehog (Shh) is produced by the cells of the ZPA and has been shown to play an important role in this process of pattern formation. Grafting the cells of the ZPA onto developing host tissue induces mirrorimage limb duplication. In addition to this, exposing …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that the proliferation defect of granule cells is associated with SHH - N-Myc pathway impairment in the nax mutant …
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