Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Sheet formation"”.
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Analysis of the thermodynamic determinants of protein fold specificity in the denatured state ensemble
… their respective folds using only energetic information. The success of our study and the unique energetic information found in denatured states suggest a wide range of strategies for developing novel algorithms for protein prediction and classification. \r\nIn addition, this work has …
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Design and synthesis of constrained dipeptide units for use as β-sheet promoters
The study of factors promoting beta-sheet formation has recently gained interest due to the suspected involvement of beta-sheets in brain degenerative diseases such as Alzheimer's disease (AD), Creutzfeldt-Jacob disease (CJD) and bovine spongiform encephalopathy. Understanding beta-sheet formation …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… Protein misfolding and aggregation into β-sheet rich fibrillar aggregates is connected with over 20 neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized in part by misfolding, aggregation and deposition of the microtubule associated tau protein into …
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Dissecting the Functions of Classical Cadherins in Skin
… in vitro analysis of de novo epithelial sheet formation, and transgenic RNA interference to overcome these issues in order to define the contribution of classical cadherins in epidermal physiology. Loss of E-cadherin in the skin epithelium revealed striking differences by which epidermis …
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A Potential Flow Model of a Fire Sprinkler Head
… of the thickness and velocity of unstable fluid sheets. The model outlined forgoes traditional CFD to solve for water jet-deflector interactions, and instead describes the sheet formation as a potential flow boundary value problem, utilizing a free surface formulation and the superposition of the …
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Computational approaches to modeling the conserved structural core among distantly homologous proteins
… quantities of proteins, and 3-D structural information for a much smaller number of proteins. We introduce several algorithms that make use of the limited available structural information to classify and annotate proteins with structures that are unknown, but similar to solved structures. The …
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Modeling the formation of current sheets in symmetric and asymmetric reconnection
… reveal a number of regimes of current sheet formation, all of which are associated with significant anisotropic heating. Finally, we take a closer look at the case of antiparallel reconnection, where small levels of asymmetry cause significant shortening in the current sheet that …
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Steady and unsteady visco-resistive reconnection in the presence of the Hall effect
… conditions. These singularities signal current sheet formation. We consider a general set of initial conditions and find that the singularities will form in this self-similar solution unless the axial field is many orders of magnitude larger than the planar field. In Chapter 5, we review the …
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Synthesis and Characterization of New Cyclic and Acylic Ferrocene Peptide Conjugates
… observation is believed to occur because of a conformational change in 1. The last area of synthesis that was done was the attempt at β-sheet formation using Fc as a scaffold to align peptide strands. Two systems were studied in this thesis [Fc(n’-AA-OMe)(1-AA)]₂-1,4butyl diamine. (AA =Ala (8), …
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Nanoscale investigation of silk proteins using near-field optics
… Understanding the mechanisms that underpin the β-sheet formation and deformation as well as the formulation of strategies to control inter- and intramolecular bonds within silk protein matrices is paramount for the control of protein structures and the improvement of material properties. However, …
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Formation of salt crystal whiskers on nanoporous coatings and coating onto open celled foam.
… at a position above the original liquid level. Sheet-like crystals also formed from whiskers that had fallen flat onto the porous coating surface. Inspired by the sheet formation mechanism and liquid transportation phenomenon, a seeding technique was developed to reduce whisker width. Attritor …
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A computer-simulation-based molecular-thermodynamic model for shape-based screening of peptide amphiphile micelles in vaccines
… fibers, vesicles, globular aggregates, nanosheets) and their morphology strongly correlates with their bioactivity, understanding equilibrium micelle shape is of considerable academic and practical interest, particularly when it comes to the engineering of the structure of a PA to achieve a …
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Self-Assembly of Large Amyloid Fibers
… short hydrophobic template peptide induces a conformation change within a highly α-helical adder protein to form β-sheets that continue to assemble into micrometer sized amyloid fibers. This study utilizes a variety of proteins that have template or adder characteristics which suggests that this …
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De Novo Design and Stabilization of β-Sheet Peptides for Biomimicry of ORR Enzymes
… how fungal laccases catalyze this transformation efficiently. It also outlines the synthetic strategy for solid phase peptide synthesis employed in the design and construction of peptide models for the purpose of emulating the active site architecture of laccase. Chapter two focuses on …
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Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
… fibrillar structures that have predominantly β-sheet secondary structure. Thus it is imperative to elucidate the structural elements that contribute to β-sheet formation and stability. Peptides that autonomously form β-sheets are ideal models to study principles of protein folding and design. …
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ANTARCTIC GLACIAL CHRONOLOGY REFLECTED IN THE OLIGOCENE THROUGH PLIOCENE SEDIMENTARY SECTION IN THE ROSS SEA
… These ice shelves coalesced to form an ice sheet over West Antarctica, including the Ross Sea, in the middle Miocene. IRD percentages in the Ross Sea glacial section increased rapidly at this time and remained high through the late Miocene and early Pliocene as the Ross Ice Sheet developed …
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Model membrane interactions with ions and peptides at the air/water interface
… charged lipids and even can fold into beta-sheet structure in the vicinity of charged membranes at high peptide to lipid ratio. It was elucidated that in the absence of electrostatic interactions B18 does not influence on the lipid structure, whereas it provides partial liquidization of the …
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Phase transitions in soft matter: From colloidal suspensions to biomolecular condensate regulation
… not only enhances our understanding of ice formation but also provides valuable insights relevant to atmospheric processes and climate modeling. Moreover, we then make use of enhanced sampling techniques to measure the NaCl-water solution interfacial free energy, a measurement never …