Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Sharpless asymmetric dihydroxylation"”.
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The Synthetic Utility of Enol Derivatives and the Directed Aryltitanation of Homoallylic and Allylic Alcohols
… enol benzoates are subjected to the Sharpless Asymmetric Dihydroxylation to form enantiomerically enriched alpha-hydroxy aldehydes. Due to their instability, these alpha-hydroxy aldehydes are further transformed in situ to demonstrate their utility in organic synthesis. The second and …
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Generating structural diversity in \(\alpha\)[alpha],\(\alpha\)[alpha]-difluoromethyl ketones
… products have been tested for reactivity in Sharpless Asymmetric Dihydroxylation. A 1,4-diene has been converted through to a fluorinated analogue of a dideoxyxylulose. A 1,3-diene has been successfully converted through to a difluorodeoxyxylulose of current interest. Key points involve …
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Total synthesis of a virotoxin and analogs for conformational studies
… residue, including a diastereoselective dihydroxylation. Nα-Carbobenzyloxy-(2S)-4,5-dehydroleucine was coupled with valine ethyl ester to give a dipeptide that was subjected to a Sharpless asymmetric dihydroxylation to introduce the diol. The relative configuration at C4 was assigned as S …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
Pyranonaphthoquinone lactones have been recently found to be selective inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of …