Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Sharp Wave Ripples"”.
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Granular retrosplenial cortex layer 2/3 generates high frequency oscillation events coupled with hippocampal sharp wave-ripples and Str. LM high gamma
… these processes take the form of theta and sharp wave ripples (SPW-Rs) for encoding and consolidation, respectively. As an animal runs through an environment, neurons become active at specific locations in the environment (place cells) increasing their firing rate, functionally representing …
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Memory processing of novel experiences in the hippocampus
… in local field potential recordings, called ‘sharp wave-ripples’. I show that during sharp wave-ripples, which are believed to reflect a retrieval mode of the hippocampal network, the place cells that were active in a novel environment fired more often than other place cells that were active …
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Noradrenaline: active in arousal, but not for the hippocampal-neocortical dialogue
… that neocortical-hippocampal dialogue during sharp wave ripples is essential for memory consolidation. Although studies suggest the importance of noradrenaline in memory formation and memory consolidation at cellular and synaptic level, less is known about the role of noradrenaline in system …
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Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… of two oscillatory patterns, the high frequency sharp-wave ripple oscillation thought to be involved in the long term storage of memories, and the high amplitude pathological oscillations associated with epileptic seizure. Hippocampal sharp-wave ripples are observed in CA1 during inactivity and …
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The temporal and bilateral structure of hippocampal replay
… is investigated at the levels of hippocampal sharp-wave ripples and multi-unit activity. We found that, during sleep, ripples generation is modulated by a 10-15Hz rhythm. We also observed this rhythm in the multi-unit firing rate of hippocampal neurons. Next we investigated and quantified the …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… to circuit activity, such as theta and sharp wave-ripple oscillations. The precise roles of each interneuron group is not well understood, though characterization of their activity reveals mechanisms underlying hippocampal circuit computation. In this dissertation, I aim to identify and …
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The effect of nucleus reuniens inactivation on neocortical K-complex and hippocampal sharp wave-ripple correlations
… to rely on coordinated interactions between sharp wave-ripples (SPWRs) and K-complexes (KCs). The aim of my study was to investigate whether inactivation of reuniens affects SPWR and KC coordination. I found that dialysis of lidocaine into reuniens did not affect the coordination of KCs and …
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Methods for Ripple Detection and Spike Sorting During Hippocampal Replay
In the rat hippocampus, fast oscillations termed sharp wave ripples and an associated sequential firing of neurons, termed replay, have been identified as playing a crucial role in memory formation and learning. The term 'replay' is used since the observed spiking encodes patterns of past …
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Influence of perforant path synaptic excitation on the initiation of hippocampal sharp-wave ripple activity in vitro
Sharp-wave ripples (SWR) generated in the CA3 subregion of the hippocampus (HC) during rest and sleep appear to coordinate memory consolidation to the neocortex (NC) by (1) reactivating small subsets of neurons (i.e. cell-assemblies) that encode recent waking experience and (2) propagating this …
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Multifunctional Polymer Fiber Probes for Biomedical Application
… infusion of CB1R agonist downregulated theta and sharp wave-ripple oscillations (SPW-Rs). Furthermore, we found that CB1R activation reduces sharp wave-ripples by impairing the innate SPW-R-generating ability of the CA1 circuit. Microscale electroporation devices are mostly restricted to in vitro …
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A Closer Look at Classical Measurement, an Algorithm for Deliberation in Rodents, and a Conjecture on Intertemporal Choice
… the slow oscillation, spindle oscillations, sharp wave-ripples, θ-sequences, for-ward and reverse SWR-sequences, the formation and strengthening of episodic memories, and a need for two modes of operation—online and offline. The two parts described above are the main content of this thesis. …
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Modulation of hippocampal sharp wave-ripple activity in vitro
Sharp wave-ripple-complexes (SPW-Rs) in the intact rodent hippocampus are characterized by slow field potential transients superimposed by ~200 Hz ripple oscillations. Similar events have been recorded in hippocampal slices where SPW-Rs occur spontaneously or can be induced by repeated application …