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Showing 1 to 20 of 23 for “"Sglt1"”.
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Untersuchungen zur Interaktion von Quercetin-Glukosiden mit dem intestinalen Glukose-Carrier (SGLT1)
… lokalisierte Na + -abhängige Glukose-Carrier (SGLT1) an der Absorption bestimmter Quercetin-Glykoside beteiligt sein könnte. In der vorliegenden Arbeit wurde deshalb mit Hilfe zweier in vitro-Methoden zum einen der Einfluss von Quercetin, von Quercetin-3-Glukosid (Isoquercitrin), von …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… via the sodium-dependent glucose transporter 1 (SGLT1) expressed by L-cells and K-cells, as demonstrated by *in vitro* cell based studies. SGLT1 is expressed throughout the intestinal epithelium and additionally facilitates glucose absorption to the bloodstream. In contrast to *in vitro* …
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Novel Mechanisms of Kinase Independent Pro-Survival Functions of EGFR in Cancer
… in mice. It was known that EGFR interacts with SGLT1 and stabilizes it in a kinase-independent manner to maintain the intracellular glucose concentration and inhibiting SGLT1 activity sensitized prostate cancer cells to EGFR TKIs. However, the role of SGLT1 in EGFR kinase inhibited conditions …
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Small Intestinal Transporters in Two Species of Galliformes: Male and Female Turkey (Meleagris gallopavo) and Chicken (Gallus gallus)
… and sugar transporter expression (GLUT2, GLUT5, SGLT1) in the small intestine of male and female turkeys. Small intestine samples were collected during embryonic development (E21, E24) and DOH. In a separate experiment during post-hatch development (DOH, D7, D14, D21, D28). APN, bo,+AT, PepT1, …
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Fettsucht mit erhöhter D-Glukose-Absorption im Dünndarm durch Inaktivierung des Regulatorproteins RS1 bei Mäusen
… RS1 die Menge des Na+-D-Glukosekotransporters SGLT1 in der Plasmamembran transkriptionsunabhängig reduziert. Entsprechend seiner dualen Lokalisation beteiligt sich RS1 aber auch an der Transkriptionsregulation im Zellkern. In der vorliegenden Arbeit konnten Informationen über die physiologische …
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Developmental Gene Expression in the Small Intestine of Chickens from Lines Divergently Selected for High or Low Juvenile Body Weight
… EAAT3, the sodium-dependent glucose transporter SGLT1, and the fructose transporter GLUT5 in the small intestine of chickens from lines divergently selected for high (HH) or low (LL) eight-week body weight and their reciprocal crosses, (HL and LH). Chicks were weighed and killed on embryonic day …
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Distribution and Relative Abundance of Nutrient Transporter mRNA in the Gastrointestinal Tract of Black Bears
… transporter (PepT1), a glucose transporter (SGLT1), two AA transporters (NBAT, bo,+AT), and a digestive enzyme, aminopeptidase N (APN), in the intestinal tract of black bears were investigated. Ten bears were used for this study. For tissue collection, the intestine was removed from the …
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Developmental Regulation of the Expression of Nutrient Transporter and BrushBorder Membrane Hydrolase Genes in the Small Intestine of Piglets
… (Na+-dependent glucose transporter 1, SGLT1, and facilitated glucose transporter 5, GLUT5), a peptide transporter (H+-dependent peptide transporter 1, PepT1), four amino acid transporters (excitatory amino acid carrier 1, EAAC1, Na+-dependent neutral amino acid transporter, ATB0, the …
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Gene Expression of Nutrient Transporters and Digestive Enzymes in the Yolk Sac Membrane and Small Intestine of the Developing Embryonic Chick
… CAT1, and B0AT, monosaccharide transporters SGLT1 and GLUT5, and digestive enzymes APN and SI. Expression of these genes was measured in YSM at embryonic day (e) 11, 13, 15, 17, 19, 20, and 21 and small intestine at e15, e17, e19, e20, and e21. Absolute quantification real-time PCR assessed …
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Dietary and Developmental Regulation of Nutrient Transporter Gene Expression in the Small Intestine of Two Lines of Broilers
… BoAT and EAAT3), four sugar transporters (SGLT1, SGLT5, GLUT5, and GLUT2), and a digestive enzyme, APN. For PepT1, Line B had greater quantities of mRNA compared with Line A (P = 0.001), suggesting a greater capacity for absorption of AA as peptides. Levels of PepT1 mRNA were greatest in …
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Effects of Chronic High Sucrose With Dietary or Drinking Inclusion on the Electrogenic Glucose Absorption in the Intestinal Tract of Mice (Mus musculus)
… an SGLT2 inhibitor or phloridzin dihydrate, an SGLT1 inhibitor were evident, gene expression analysis of the SGLT 1- 6 could not fully explain these regional differences in kinetics. Non-the-less, the kinetics were highly modified by sucrose treatments, with a significant shift in the segmental …
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Ontogeny and biological function of epithelial cells in the chicken yolk sac and small intestine
… expression of nutrient transporters (PepT1 and SGLT1), intestinal stem cell markers (Lgr5 and Olfm4), and avian beta defensins in the chicken yolk sac and small intestine during the embryonic and early posthatch stages. RNAscope in situ hybridization was used to identify the distribution of …
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Der plasmamembran assoziierte Transportregulator RS1 bindet Ubiquitin und gelangt in den Zellkern
… kann, wo es an der Transcriptionsrepression des SGLT1 beteiligt ist.
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Expression of Digestive Enzymes and Nutrient Transporters in the Intestine of Eimeria-challenged Chickens
… sugar transporters: GLUT1, GLUT2, GLUT5 and SGLT1, mineral transporter: ZNT1 and an immune factor: LEAP2 in the duodenum, jejunum, ileum and ceca of Eimeria-challenged layers and broilers. Comparisons were made between E. acervulina-challenged layers and broilers and E. acervulina, E. maxima …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… of glucose transporter genes (GLUT2 and SGLT1) and induced an acute (15 min) inhibitory effect on enterocytic glucose uptake. 2) Chronic treatment (16 h) with berry extract modulated the expression of genes that regulate iron uptake (down-regulation of DMT1, DCYTB and HFE; up-regulation …
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Production, characterization and evaluation of anti-diabetes peptides from proteins of improved common bean (Phaseolus vulgaris L.) cultivars using bioinformatic tools, enzymatic systems, and in vitro and in vivo models
… and blocking intestinal glucose transporters SGLT1 and GLUT2. Besides, using Caco-2 cells monolayer insert we observed that protein fractions reduce glucose absorption by 6.5 and 24.5 after 30 min and 24 h, respectively. It could be due to protein fractions were also able to decrease protein …
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Regulation of Glucose Uptake and Transporter Expression in the North Pacific Spiny Dogfish (Squalus suckleyi)
… activation. A similar trend was also shown for sglt1 in the rectal gland, and the ability of GLUT and SGLT inhibitors to prevent chloride secretion solidified the importance of glucose uptake for gland function. The exogenous factor of salinity was also investigated and high levels of glut mRNA …
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Effects of Incubation Temperature and Transportation Stress on Yolk Utilization, Small Intestine Development, and Post-Hatch Performance of High-Yield Broiler Chicks
… measurements and relative nutrient transporter (SGLT1, GLUT2, GLUT5, EAAT3, and PepT1) gene expression. The objective of the second study was to evaluate the effects of embryonic incubation, simulating a multi-stage incubation system, and post-hatch transportation temperatures on post-hatch …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… sodium-dependent glucose cotransporter-1 (SGLT1) and glucose transporter 2 (GLUT2). GLUT2 is a high-capacity, facilitative intestinal monosaccharide transporter that is upregulated by the short-chain fatty acids (SCFA) derived from the intestinal microbiota during fermentation. The …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… conditions. This effect was hampered by SGLT1/2 inhibitor sotagliflozin, as well as by knock-out of SGLT1 in the GIP-Venus human organoid line, indicating that this sodium-coupled glucose transported is needed for the secretion of GIP from human K-cells. Importantly, we showed for the …
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