Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Sex as a Biological Variable"”.
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
Sex as a biological variable (SABV) has historically been overlooked in biomedical research, creating a critical gap in our understanding of how sex influences physiological and therapeutic outcomes. This is particularly important in infectious diseases such as Clostridioides difficile infection, …
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Understanding the effects of sex chromosomes and sex hormones on sex differences
Biological factors that determine sex and drive sexual differentiation have long been established in humans and other mammalian species. Yet there is a limited understanding of the mechanisms by which these factors give rise to sex-biased outcomes in health and disease. Growing evidence for sex …
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Interactions Between Gut Microbial Composition, Mucosal Immunity and Metabolism
… microbiome contributes to host health and disease has rapidly developed, the causal mechanisms that link these microbes to disease are largely elusive. The goal of this project was to explore the complex crosstalk between the microbiome and the immune system using genetically defined mouse …
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Diabetes and the Female Heart
… to diabetic men. The mechanisms underlying these sex specific outcomes remain unclear. This thesis investigated how sex and type 2 diabetes interact to influence cardiac mechanics, energetics, and structure, focusing on cardiac excitation contraction coupling (ECC) - a critical cellular event that …
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Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
… and only a limited number of findings from basic research have successfully translated into effective therapies. This translational gap underscores the need for improved preclinical models and for objective physiological biomarkers that can reliably reflect nociceptive processing and …