Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Severe malaria"”.
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Host Response to Plasmodium Infection: Implications for Pathogenesis and Management of Severe Malaria
Cerebral malaria (CM), caused by
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Immune responses to polymorphic antigens and protection against severe malaria in Kenyan children
… by which individuals acquire immunity to malaria are poorly understood and although antibodies are thought to be central, evidence that specific anti-malarial antibodies are associated with protection from clinical episodes of malaria has been conflicting.<br></br><br></br>I hypothesized …
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Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches
P. falciparum malaria remains one of the leading public health problems worldwide. The global tally of malaria in 2018 was estimated at 228 million cases and 405, 000 deaths worldwide. African countries disproportionately carry the global burden of malaria accounting for 93% and 94% of cases and …
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… the world, a dwindling arsenal of anti-malarials and a predilection for use of less than ideal murine models, the need for effective, applicable and established animal models through which to understand severe malarial disease and test potential treatments is becoming increasingly …
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Regulation of transcription in Plasmodium falciparum, the causative agent of severe malaria: initial characterisation of PfTBP and PfTFIIA
Malaria, caused by Plasmodium parasites, remains a leading cause for morbidity and mortality worldwide, resulting in more than 430 000 deaths annually. P. falciparum is responsible for the vast majority of severe malaria cases, accounting for more than 90% of malaria-related fatalities, …
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The efficacy and safety of artesunate suppositories in combination with other antimalarials in the treatment of severe malaria in Sudan.
… in Africa with no experience in Sudan. Severe malaria in Sudan is common in its rural areas where lack of facilities for the safe and effective parenteral use of quinine causes long delays before the patient can reach a suitable centre for treatment. An early treatment with artesunate …
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Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
Severe malaria infections cause almost 1 million deaths annually, mostly among non-immune African children. The pathogenesis of severe malaria is poorly understood. It is increasingly appreciated that while host innate immune responses such as inflammation and phagocytosis are critical for control …
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Economic costs of seeking malaria care to households in the Kassena-Nankana district of Northern Ghana
Although, malaria is a major problem in Ghana, as III many Sub-Saharan Africa countries, there has been little research on its economlC impact, particularly at the household level. National statistics only show that malaria accounted for more deaths, more cases and more potential days of life lost …
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An investigation of the relationship between malaria and red-cell polymorphisms in Madang, Papua New Guinea
… a heterozygote survival advantage against malaria. This “malaria hypothesis” formed the basis for this programme of research. Between 1993 and 2006, | conducted a series of comprehensive and detailed studies of the relationships between malaria and the common red-cell variants …
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Leveraging genotypes imputation and polygenic risk scores in malaria susceptibility
… as their genetic architectures are concerned. In malaria studies too, GWAS has been successful and a number of genetic variants have been identified. Despite the success, the complete aetiology of malaria, and many complex traits in general, remains poorly understood. A key concern is that the …
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Determination of Tumor Necrosis factor-a, Interluekin-10, Interluekin-12, and Intercellular adhesion molecule-1 levels in relation to Malaria severity in children
Malaria is highly prevalent in sub-Sahara Africa and is the leading cause of morbidity and mortality accounting for approximately one million deaths per annum. Disease severity and parasitaemia have been linked to cytokine levels, but their relationship requires further elucidation. Better …
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Determination of Tumor Necrosis factor-a, Interluekin-10, Interluekin-12, and Intercellular adhesion molecule-1 levels in relation to Malaria severity in children
Malaria is highly prevalent in sub-Sahara Africa and is the leading cause of morbidity and mortality accounting for approximately one million deaths per annum. Disease severity and parasitaemia have been linked to cytokine levels, but their relationship requires further elucidation. Better …
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Factors associated with malaria-anemia in under-five children in selected communities in Zambia
Background:Severe anaemia due to infection with complicated falciparum malaria remains a significant cause of morbidity in children under the age of 5 years, especially in endemic areas. Severe malarial anaemia increases the risk cognitive impairment and functioning, retarded growth and death. The …
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Anti-malaria drug treatment in Vietnam
Resistance to antimalarial drugs is increasing nearly everywhere in the tropical world, confounding global attempts to "Roll Back Malaria". Antimalarial treatment with artemisinin, artesunate, or artemether has proved rapidly effective in the treatment of non complicated and complicated malaria and …
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An investigation of the protective effect of alpha+-thalassaemia against severe Plasmodium falciparum amongst children in Kumasi, Ghana
… against death from Plasmodium falciparum malaria. The most common type of alpha+-thalassaemia amongst people of African descent is the -α3.7 deletional type and affects 26-33% of Ghanaians. Plasmodium falciparum malaria is a major cause of mortality amongst children in sub-Saharan Africa. …
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Identification of Host and Parasite Factors Mediating the Pathogenesis of Severe and Cerebral Malaria
Severe manifestations of malaria, including cerebral malaria (CM) and respiratory distress, result in approximately three million deaths annually worldwide. Currently, relatively little is known about severe disease pathogenesis. The development and outcome of severe malaria is determined by …
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Recognition of malaria, treatment seeking behaviour and perception of the causes and effects of malaria among women attending antenatal clinic in Mudzi district in Zimbabwe
Malaria is an important public health problem with a high morbidity and mortality in more than 90 malaria endemic countries in the world. The burden of malaria is quite high especially among pregnant women and children under five years of age. There has been little focus on the factors that …
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Functional Genome Wide Association Study in Susceptibility and Resistance of Malaria
Background: More than century, malaria is qualified as a mortal infectious disease, worldwide causing high morbidity and mortality. The World Health Organization (WHO) has shown that, Distribution of Malaria in Africa takes a major part, it's accounting for 95% (about 229 million) and 67% (about …
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Gut Microbiome Dysbiosis Exacerbates Malaria Severity in Ugandan Children
Malaria is a life-threatening infectious disease caused by the parasite Plasmodium. Sub-Saharan Africa faces the greatest disease burden and most deaths from severe malaria (SM) occur in children <5 years old. The pathogenesis of SM is not fully known, but murine studies implicate the gut …
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