Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Severe hypoglycemia"”.
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Glucosensing, Hypoglycemia, and the Brain
… brain regulates hypoglycemic counterregulation. Hypoglycemia is a major limitation to the treatment of diabetes. Severe hypoglycemia can lead to brain damage, cognitive dysfunction, and death. Understanding how to prevent the complications of severe hypoglycemia is critical to helping patients …
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Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
… of diabetes, as well as increased risk of severe hypoglycemia as occurs with insulin therapy. Thus, understanding how the brain senses and responds to changes in glucose is particularly important to individuals with diabetes. Experiments in this thesis investigated: 1) the role of neuronal …
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Clinical and Psychological Outcomes of Flash Glucose Monitoring in Adults with Type 1 Diabetes on Multiple Daily Injections of Insulin: A Population-Based Study in Andalusia, Spain
… a high burden of acute complications, such as severe hypoglycemia and diabetic ketoacidosis (DKA), and chronic complications, including cardiovascular events and amputations. In addition, psychological factors—particularly Fear of Hypoglycemia (FoH)—represent significant barriers to achieving …
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BLOOD GLUCOSE MONITORING AND METABOLIC CONTROL IN YOUTH WITH TYPE 1 DIABETES: RELATION TO DISEASE CARE
… Additionally, youth who experience frequent or severe hypoglycemia may develop a fear of hypoglycemia, which may impact their disease care behaviors and blood glucose levels directly. Average blood glucose levels strongly related to HbA1c which verifies HbA1c as a good indicator of average blood …
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Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
… response when blood glucose levels are too low: hypoglycemia). Insulin-dependent people with Type 1 diabetes: T1DM) have an impaired ability to sense hypoglycemia and an impaired ability to activate this counterregulatory response: CRR) to hypoglycemia. As a result, T1DM are at a greater risk of …
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Development and Application of Solid-State NMR Methods for Investigating Protein Structure and Dynamics
… that is used as a pharmaceutical agent to treat severe hypoglycemia. Unfortunately, it rapidly fibrillizes at pharmaceutically-relevant concentrations and pH and is thus shipped as a dry lyophilized powder and a diluent solution. Utilizing SSNMR we have solved the high-resolution structure of …