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Showing 1 to 17 of 17 for “"Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria"”.
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
This PhD research project aimed to investigate immune system functions in healthy and pathologic experimental murine models, through immunohistochemical characterization of immune cell populations in healthy steady state, inflammatory and neoplastic settings. The following fields were investigated: …
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MOUSE MODELS OF IMMUNODEFICIENCY
Despite the extensive employment of immunodeficient mouse models, their immune status is seldomly assessed by the research community, with possible unexpected and misleading results from the experiments. Furthermore, no standardized system for such assessment currently exists. This calls for the …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… an analysis of the grading systems proposed in veterinary medicine. The relationship between tumour morphology and clinical behaviour is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based …
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CLINICAL APPLICATIONS OF PARAOXONASE-1 IN DOMESTIC ANIMALS: BEYOND CONVENTIONAL INFLAMMATORY MARKERS
… and/or oxidative stress, both in human and veterinary medicine. In veterinary species, PON-1 measurement is to date primarily restricted to the research field and has not been yet undertaken in the routine clinical field. However, recent research has highlighted promising utility in many …
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IDENTIFICAZIONE DI NUOVI BIOMARKER E METODI ANALITICI INNOVATIVI IN PATOLOGIA CLINICA VETERINARIA
… a possible application as a useful marker in veterinary medicine. Four different objectives are investigate: 1. Haematological parameters: two new gates are draw, in particular a “high fluorescent region” to identify canine blood samples with cell of probable neoplastic origin that need …
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IMMUNOPROFILE IN EFFUSION CYTOLOGY
BACKGROUND: Cytology has a crucial role for diagnosing pleural and abdominal effusions. A prompt accurate diagnosis has both prognostic and therapeutic significance. However, cell morphology alone is not always sufficient to formulate such a diagnosis. In human medicine, immunocytochemistry of …
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SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT
The aims of the work presented in this thesis were to investigate the bovine acute phase protein Serum Amyloid A, focussing on its value as safety marker in farm animals. SAA can be considered as a natural anti-inflammatory and immunomodulatory agent and local expression of SAA, at the site of the …
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BIOINFORMATIC PIPELINES AND MICROBIAL DATABASES FOR THE ANALYSIS OF DAIRY COWS 16S RRNA-GENE SEQUENCING DATA: A BENCHMARKING STUDY.
… Tuttavia, la rapida crescita di questo settore nella ricerca zootecnica ha portato a una mancanza di linee guida su come queste pipeline differiscano tra di loro e come queste differenze possano influenzare i risultati finali. Metodi Questo studio mira a confrontare quattro diversi …
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PARATHYROID HORMONE ACTIVITY AND RELATED CLINICOPATHOLOGICAL ALTERATIONS IN DOGS AFFECTED WITH CHRONIC KIDNEY DISEASE
Renal secondary hyperparathyroidism (RHPT) is a common complication in humans and dogs affected with chronic kidney disease (CKD). RHPT is promoted mainly by the loss of nephrons and consequent hyperphosphatemia and its severity increases in parallel to the disease. The identification and …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
… among different studies and their application in veterinary clinical oncology. The majority of these studies have also been characterized by non-standardized and non-rigorous methods. Given these premises, the aims of this thesis were to identify valuable prognostic factors specific for different …