Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Settore MEDS-09/A - Oncologia medica"”.
-
UNDERSTANDING METASTASIS MIXED - TREATMENT RESPONSES THROUGH GENOMIC ANALYSES.
Early and metastatic breast cancers can exhibit heterogeneity, among patients and even within the same individual. Response to therapy in metastatic breast cancer patients with multiple metastases can also be heterogeneous, with different degrees of responsiveness to the same drug(s) across …
-
PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
Tumor initiation and progression depend on the metabolic reprogramming of cancer cells to meet heightened energy and biosynthetic demands. Triple-Negative Breast Cancer (TNBC), characterized by the absence of hormone and HER2 receptors, exhibits high glycolytic and oxidative phosphorylation …
-
PHARMACOGENOMICS OF OPIOID RESPONSE IN EUROPEAN ADVANCED CANCER PATIENTS
Background: Strong opioids, which are drugs in the third step of the World Health Organization’s analgesic ladder, are the standard of care for treating pain in advanced cancer patients. Unfortunately, a significant minority of them do not benefit from analgesic therapy, or experience several side …
-
MULTIPLE MYELOMA PLASMA CELL PROFILING: INTEGRATED SINGLE-CELL RNA AND VDJ SEQUENCING APPROACHES UNCOVER NOVEL CLINICAL INSIGHTS
Il Mieloma Multiplo (MM) è una neoplasia ematologica caratterizzata dalla proliferazione di plasmacellule (PCs) nel midollo osseo (BM) che secernono anticorpi. È preceduto da stadi asintomatici definiti come Gammapatia Monoclonale di Significato Indeterminato (MGUS) o Mieloma Multiplo Smouldering …
-
DEEP LEARNING ALGORITHM FOR MOLECULAR CLASSIFICATION OF ENDOMETRIAL CANCER FROM WHOLE SLIDE HISTOPATHOLOGY IMAGES
Endometrial cancer (EC) is a common malignancy whose molecular classification (POLEmut, MMRd, p53-abn, NSMP) guides prognosis and treatment. While MMRd and p53-abn can be assessed through IHC, POLEmut identification requires gene sequencing, which is costly and often unavailable. In this study, we …