Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Settore MED/13 - Endocrinologia"”.
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MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
… resembling human tumor behavior. This thesis aimed to investigate possible biomarkers underlining pharmacological resistance and predictable of SSAs/DAs responsiveness in NETs, more specifically focusing on G-proteins and β-arrestins DRD2-mediated signaling pathways in PitNETs and on …
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
… GLP1R+CD4+ and GLP1R+CD8+ T cells revealed/confirmed their tendency toward an apoptotic/anergic profile as compared to their counterparts untreated. In conclusion, GLP1R appeared to act as a negative costimulatory molecule and the GLP1R agonist Exenatide prolongs allograft survival, mitigates …
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NEW-ONSET HYPERGLYCEMIA AFTER SARS-COV-2 INFECTION
Abstract Patients who were hospitalized for coronavirus disease 2019 (COVID-19) have a higher prevalence of hyperglycemia. By altering glucose homeostasis, cytokine release brought on by The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection may hasten the onset of metabolic …
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COMPLICANZE DELL'IPERCORTISOLISMO SUBCLINICO: RISCHIO DI INSORGENZA DI FRATTURE VERTEBRALI E POSSIBILE RUOLO DELL'ORMONE DELLA CRESCITA.
… was higher in SH+ than in SH- group (48% vs 13%, P=0.001). Among the 23 patients evaluated for GH secretion, the GH peak and the GH secretory response to GHRH-ARG (expressed as the area under the curve, GH-AUC) were lower in SH+ as compared to SH- patients (22.0±19.4 vs 42.6±27.9 ng/ml, …
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AN HEALTHY DIET AND AN HEALTHY FOOD ADDED WITH L-ARGININE: BIOAVAILABILITY AND BENEFICIAL EFFECTS
… sensitivity, two further tests were performed in which 3.3 g of L-Arginine (3 biscuits) or 6.6 g of L-Arginine (6 biscuits) on 4 healthy subjects (2M/2F). After an overnight fast, samples for blood glucose and insulin measurements were taken at 0, 30, 60, 90, 120 min. Basal blood pressure …
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ANALYSIS OF B LYMPHOCYTES IN MOUSE MODEL LIGASE IV WITH HYPOMORPHIC MUTATION IN VDJ RECOMBINATION ASSOCIATED WITH GROWTH DEFECT
… effects of the impaired repair of non programmed DNA damage are more diverse and difficult to study. Although such defects in cell survival and proliferation are likely to have an impact on the immune system, their contribution to the immunodeficiency of the LigIV syndrome remains unknown.
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TARGETING THE DNA DAMAGE RESPONSE PATHWAY FOR THE TREATMENT OF AGGRESSIVE THYROID CANCERS, IN VITRO STUDIES
… Blot and immunofluorescence analyses were performed to characterize the DDR pathway in untreated condition and in response to Doxorubicin (DX), an agent that induces DNA double-strand breaks, in a panel of TC cell lines with known TP53 alterations. These methods were also used to evaluate the …
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NODULI TIROIDEI NELL'ACROMEGALIA: RUOLO DELL'ELASTOSONOGRAFIA
… (ES 1-2) or hard (ES 3-4). FNAC could be performed in 60.8% of hard nodules in acromegalic patients and in 86.7% of hard nodules in controls. Results: The prevalence of hard nodules in patients with active acromegaly (68.9%) was greater, though not to a statistically significant extent, than …
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