Global ETD Search
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Showing 1 to 20 of 22 for “"Settore MED/09 - Medicina Interna"”.
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THE ROLE OF BETA-KLOTHO PROTEIN IN NAFLD PATHOGENESIS
… fibroblast growth factor receptors 4 (FGFR4), mediates in the liver the hormonal activity of FGF19 and plays a central role in the regulation of lipid metabolism and in bile acids’ biosynthesis. Thus, a stable KLB full knock-out model in HepG2 hepatoma cells (KLB-/-) has been generated by using …
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STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES
… transcriptional and epigenetic landscape is formed in the earlyTfh21 stage and is maintained throughout the exTfh21 state, suggesting terminal differentiation. We also clarify that the transcription factor Foxp1 intrinsically regulates the transition between these stages in Tfh cells. Through …
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PNPLA3 P.I148M VARIANT INCREASES LIPID DROPLETS NUMBER AND SIZE IN PATIENT-DERIVED LIVER ORGANOIDS
PNPLA3 rs738409 C>G p.I148M variant is the main genetic determinant of metabolic associated steatotic liver disease (MASLD). To this day, this association still lacks a molecular characterization, due to the lack of comprehensive human models. To overcome this gap in knowledge, we generated …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… disease suggesting the potential role of this mediator in the pathogenesis of these forms of angioedema. Based on these observations, we planned a study on a larger cohort of subjects. We planned a study on a cohort of subjects consisting of 50 consecutive patients with angioedema attending the …
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RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.
Introduction: Cardiac fibrosis is a pathological response that causes abnormalities in cardiac conduction and mechanical function, thereby contributing to the pathophysiology of a variety of cardiac conditions, including hypertrophy, failure, and arrhythmias. Atrial fibrillation (AF) is the most …
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VALUTAZIONE DI UNA COMPONENTE A BASSA FREQUENZA DELLA VARIABILITÀ DELLA PRESSIONE ARTERIOSA SISTOLICA IN PAZIENTI CON FIBRILLAZIONE ATRIALE PERSISTENTE E SUA SUCCESSIVA ULTERIORE VALUTAZIONE MEDIANTE LINGUISTIC ANALYSIS
Atrial fibrillation (AF) is a common arrhythmia characterized by irregular ventricular response. During AF, beat-to-beat variability of arterial pressure (AP) is increased because of continuous changes in filling time, stroke volume and contractility. Only a few studies have analyzed short-term AP …
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GLOBAL COAGULATION ASSAYS AND HEMOPHILIA ARTHROPATHY SCORES FOR MONITORING EMICIZUMAB PROPHYLAXIS IN PATIENTS WITH HEMOPHILIA A
… che attesta l’artropatia emofilica sulle medesime articolazioni (HEAD-US score). Il coefficiente di correlazione Rho di Spearman è stato utilizzato per valutare l'associazione tra le variabili. Quindi è stato utilizzato un modello di Cox per valutare l'associazione tra ciascun parametro …
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