Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Settore CHIM/09 - Farmaceutico Tecnologico Applicativo"”.
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CAPSULAR DEVICES FOR ORAL MODIFIED RELEASE OF DRUGS PREPARED BY INJECTION MOLDING
The research project was focused on the development of a pulsatile capsular-shaped drug delivery system (DDS) named ChronocapTM. It consists of a capsule shell, made of hydroxypropyl cellulose (HPC), prepared by injection molding (IM); it is intended to be filled with different types of drug …
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Innovative formulations for the treatment of Plasmodium infections
Nanomedicine is one of the most innovative strategies to target drugs at the action site and increase their activity index. Phytomedicine is the most traditional method used to treat human diseases and solve health problems. Their combination represents the future prospective to a better care of …
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Preparation, development and evaluation of novel drug delivery systems for colon targeting
Il direzionamento di farmaci al colon sta assumendo un ruolo sempre più importante non solo per il targeting di farmaci usati nel trattamento di patologie del colon ma anche come sito per l’assorbimento e raggiungimento sistemico di proteine. Lo scopo di questo lavoro è stato quello di preparare …
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New lipid nanovesicles as topical delivery sistems for ant-inflammatory drugs
The purpose of the present study was to formulate new vesicular carriers to optimize the topical delivery of anti-inflammatory drugs: diclofenac, quercetin and curcumin. In the first work concentrated and interconnected penetration enhancer containing vesicles (PEVs) are proposed as carriers for …
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Nanocarriers for drug targeting and improved bioavailability
This PhD thesis debates, mostly, on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
Various types of rifampicin (RIF)-loaded microparticles were compared for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) …
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Nanoparticelle per la terapia dei tumori: preparazione, caratterizzazione e tossicità
The work of this doctoral thesis can be mainly divided in three parts. In the first part, the synthesis and characterization of different types of inorganic nanoparticles (NP) is described. The full protocol to prepare NP-GS, NP-Si)GS, and NP-Si)Au was found in literature. Stöber …
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Innovatives liposomes for overcoming biological barriers
In this thesis work were prepared and characterized liposomes and liposomes modified with a coating of chitosan called chitosomes. Through these structures were conveyed drugs of natural origin with anti-inflammatory and antioxidant properties: quercetin,phycocyanin and curcumin. The liposomes …
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Preparazione e caratterizzazione di due sistemi carrier: beads a base di chitosano e chitosano/alginato; nanoparticelle di N-trimetilchitosano
Chitosan is a very attractive polysaccharide and it is known to be a favorable pharmaceutical material because of its low toxicity, biodegradability, biocompatibility, mucoadhesivity and natural origin. Therefore it forms an ideal hydrophilic carrier system. In this study we described the …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …
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