Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Settore CHEM-07/A - Chimica farmaceutica"”.
-
APPLICATION OF OMICS APPROACHES IN DRUG DISCOVERY AND BIOMARKER IDENTIFICATION
… but have different structural and physicochemical properties. Its comprehensive analysis is, therefore, technically challenging, and advanced LC-MS-based lipidomics workflows aim to better address this complexity. Lipidomics approaches can potentially be applied in all therapeutic areas, …
-
Α-HYDROXY FATTY ACIDS AND BIOPOLYMERS: NEW FATES FOR LIPID-ENRICHED FOOD SCRAPS
… to attain products via environment-friendly chemical processes. Food scraps may be particularly enriched of fatty acids, whose potential is yet to be fully exploited. One new fate for these molecules could be represented by the conversion into new chemical entities, in this case α-hydroxy …
-
OPPORTUNITIES AND CHALLENGES OF BIOCATALYSIS IN PHARMACEUTICAL SCIENCES: DEVELOPING TAILORED BIOCATALYSTS FOR SYNTHETIC APPLICATIONS
… and sustainable alternative to traditional chemical synthesis, particularly in the preparation of stereochemically complex pharmaceutical intermediates. This doctoral research focuses on the development of tailored biocatalysts, specifically amine transaminases (ATAs), for the synthesis of …
-
INTEGRATION OF QUANTUM-MECHANICAL AND MOLECULAR DOCKING APPROACHES IN GLOBAL METHODS FOR METABOLISM PREDICTION OF XENOBIOTICS
… proton shuttle mechanism to further advance the chemical synthesis of niclosamide-based compounds in collaboration with experimental groups.
-
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ANTIPARASITIC AND ANTICANCER AGENTS
… reversible PFKFB-3 inhibitor, we explored chemical modifications surrounding the proline-based scaffold. These modifications aim to improve solubility, enhance interactions within the enzyme's active site, and potentially engage additional binding pockets. This rational design approach may …
-
NOVEL SUSTAINABLE STRATEGIES FOR THE SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) AND BIOACTIVE MOLECULES THROUGH THE EXPLOITATION OF ISOLATED ENZYMES AS BIOCATALYSTS
Green chemistry is a chemical concept, condensed in 12 principles, which aims at directing chemical industries and academic researchers to paths of sustainability, supporting the efforts in the context of the ecological transition. A valuable strategy widely recognized to fulfill most of the 12 …
-
DISEASE-MODIFYING APPROACHES TO MULTIPLE SCLEROSIS: DESIGN AND SYNTHESIS OF NOVEL POTENTIAL THERAPEUTIC AGENTS
… the SPECS screening database, composed of over 207’000 commercially available compounds. Among the compounds showing the best binding, two compounds were selected for the biological evaluation. The molecules were assessed for their ability to inhibit conversion toward a reactive phenotype induced …
-
DEVELOPMENT OF FLOW PROCESSES FOR THE EFFICIENT AND SUSTAINABLE PREPARATION OF HIGH VALUE CHEMICALS
Sustainability in chemistry involves the development and implementation of chemical processes, materials, and technologies that fulfill present needs without compromising the ability of future generations to meet theirs. Growing concerns over global pollution and resource depletion have underscored …
-
BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… both in terms of the composition and physicochemical properties of bodily fluids and hydrodynamics at the specific site of drug administration. This PhD project aimed to advance the development of biorelevant in vitro testing strategies for complex drug delivery systems intended for …
-
CHARACTERIZATION OF BIOLOGICALLY ACTIVE MOLECULES OFPHARMACOLOGICAL INTEREST EXTRACTED FROM MICROALGAE BYBIOSUSTAINABLE PROCESSES
… (DMC), in line with the principles of green chemistry. The study focused on the cultivation of the Micractinium pusillum (CELP1) strain, isolated from agricultural water sources in Sicily (Italy), and its comparison with the model species Chlamydomonas reinhardtii cc-1374. Both strains were …
-
ENGINEERING LIPID AND HYBRID NANOVECTORS FOR TARGETED GENE DELIVERY TO MACROPHAGE SUBPOPULATIONS
In this work, a structural taxonomy of these systems is proposed with the aim of clarifying the possible architectures that can arise when genetic materials are complexed with a polycation or a lipid, followed by the addition of a lipid or a polymer to ameliorate the cellular toxicity, modulate …
-
DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… quantification at each stage. Physicochemical characterization revealed uniform spherical NGs with an average size of 108.1 ± 1.2 nm and a membrane bilayer thickness of approximately 6.3 ± 1.2 nm. Minimal protein corona formation was detected using fluorescence correlation spectroscopy …
-
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… irradiation wavelengths (>420 nm) and higher chemical yield of payload release. Starting from 8-bromo-7-hydroxyquinolin-2-ylmethyl (8BHQ), the first quinoline based PPG described, we first demonstrated the ability of it in releasing tertiary amines, exploiting a residual absorption tail at 440 …
-
VIRAL SAFETY EVALUATION OF BIOTECHNOLOGY PRODUCTS: DEVELOPMENT AND OPTIMIZATIONOF RELIABLE VIRAL CLEARANCE STRATEGIES
This manuscript brings together the research activities carried out throughout my doctoral program and reflects the dual nature of the project, which developed at the interface between academic research and industrial application. The thesis is part of a broader framework dedicated to the study, …
-
DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… clearance. To address these challenges, advanced chemical modifications, such as Xeno Nucleic Acids (XNAs) and 2-OH modifications, along with specialized delivery systems, including viral vectors and lipid nanoparticles (LNPs), have been introduced. The design of these advanced ligands …
-
ARTIFICIAL INTELLIGENCE (AI) APPROACHES IN DRUG DISCOVERY: DEVELOPMENT AND VALIDATION OF NEW STRATEGIES IN VIRTUAL SCREENING CAMPAIGNS
… descriptors, avoiding the multitude of ligand chemical descriptors, far away from the purpose of Explainable Artificial Intelligence (XAI).
-
METAL COMPLEXES AND THEIR BIOLOGICAL ACTIVITY IN VIVO
… with remarkable photophysical and electrochemical properties, arising from their unique electronic structures. Complexes containing Pt(II), Ir(III), Ru(II), Cu(I) for example are characterized by the presence of partially filled d-orbitals, exhibit a range of fascinating phenomena …
-
DEVELOPMENT OF VIRTUAL SCREENING METHODOLOGIES FOR IDENTIFYING RNA-BASED THERAPIES
This thesis focuses on the development of computational methodologies for predicting protein-RNA binding affinities and designing RNA sequences with specific functional outcomes. The research introduces PANTHER (Protein-Affinity for Nucleic Target-binding, Hybridization, and Energy Regression), a …