Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Settore CHEM-05/A - Chimica organica"”.
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DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… to 15% in 2019 and forecasted to double by 2050. This demographic shift carries profound implications for healthcare systems, social welfare structures, and economic sustainability, particularly given the escalating incidence of neurodegenerative diseases prevalent among the elderly …
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LIGHT AND ELECTRICITY: POWERFUL TOOLS FOR NEW SUSTAINABLE STEREOSELECTIVE SYNTHESIS
… and analysed during this thesis work: the electrochemical dehydrogenative homo-coupling of β-Naphtylamines derivatives; the stereoselective cyclization of aryl-enones under homogeneous and heterogeneous conditions and the late-stage C-H iron (III) catalyzed electrophotochemical …
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APPLY LADDER OF CHEMICAL CIRCULARITY: RECYCLING OF RARE EARTH ELEMENTS RECOVERED FROM ELETRONIC WASTE AS A CATALYST IN ORGANIC REACTION.
… with a specific focus on continuous flow chemistry. The research extensively examines the Michael addition reaction between indoles and benzylidene malonates, employing these catalysts to achieve high reaction efficiency and selectivity. Additionally, a Diels-Alder cycloaddition was …
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SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES
… In particular, reversible covalent (RC) chemistry combines the strength of covalent binding with the tunability of non-covalent interactions, mitigating the risks of permanent off-target reactivity. Within this context, this PhD thesis explores the use of salicylaldehyde (SA) as a …
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EMISSIVE PEPTIDE NUCLEIC ACIDS (PNAS): POTENTIAL TOOLS FOR INNOVATIVE DIAGNOSTICS AND THERAPEUTICS
… their synthetic nature, PNAs also display high chemical and enzymatic stability3. All these unique features make PNAs excellent candidates for diagnostic and therapeutic applications4,5, such as detecting genetic mutations and interfering with protein production in antigene and antisense …
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TOOLS AND STRATEGIES FOR THE SYNTHESIS OF PHARMACEUTICAL ACTIVE COMPOUNDS
… will enhance the overall understanding of the chemical profile of safracins and provide a foundation for further chemical and structural investigations into their biological activities and potential applications in drug discovery. Chapter 2 focuses on the design and synthesis of novel tubulin …
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PROTEIN HYDROLYSATES FROM AGRICULTURAL WASTE BIOMASS: ENZYMATIC PREPARATION, BIOLOGICAL ACTIVITIES AND TECHNO-FUNCTIONAL PROPERTIES
… a sustainable feedstock for the manufacture of chemicals and fuels. However, research on biomass valorization has mainly focused on the conversion of the C-, H-, and O-containing fractions (i.e., carbohydrates, lignin and triglycerides), whereas the nitrogen containing fraction (i.e. proteins) …
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NATURE AND GREEN CHEMISTRY AS KEY FACTORS FOR THE SYNTHESIS OF HIGH-QUALITY APIS FOR THE PHARMACEUTICAL INDUSTRY
… of an innovative approach to the application of chemistry in all fields with the aim to reduce the environmental impact of pharmaceutical industrial processes. From this perspective, green syntheses are more convenient for pharmaceutical companies and global society due to economic, environmental …
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LIGHT-DRIVEN STRATEGIES FOR THE GENERATION OF N-OXAZOLIDINONE RADICALS AND THE SYNTHESIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
Recent advances in radical chemistry have opened new opportunities in synthetic methodology, enabling the resolution of challenges that more conventional methodologies have historically encountered. This PhD thesis work aims to investigate two different research topics as outlined in Figure I: (A) …
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Mechanochemistry: Redefining the Paradigm of Organic Chemistry
… to International Union of Pure and Applied Chemistry (IUPAC), mechanochemistry has been recognized as one of the most innovative transformative technologies in the context of green and sustainable organic synthesis. Mechanochemistry offers discrete reactivities compared to their …
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Development of new visible-light mediated reactions
… to develop new synthesis methodologies in photochemistry and photocatalysis starting from readily accessible starting materials, prioritizing, whenever possible, the use of low environmental impact methodologies and technologies (using green solvents and oxidants, one-pot reactions, visible …
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Thermally Activated Delayed Fluorescence Emitters: Molecular Design, Photophysics, and Sensing Application
… organic light-emitting diodes (OLEDs), including chemical sensing. In this thesis, coumarin-based donor-acceptor systems are investigated as a versatile platform for the development of TADF-active emitters and their integration into functional sensing materials. Following an overview of the …
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EXPLORING UNPRECEDENT SYNTHETIC ROUTES FOR CHIRAL AMINO DERIVATIVES
… transition-metal catalysis, and continuous-flow chemistry. The work explores the synthetic potential of light-driven processes to access reactive open-shell intermediates under mild and sustainable conditions, enabling transformations that are difficult or inaccessible using conventional …
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SYNTHESIS AND STRUCTURAL DESIGN OF CARBOHYDRATE-BASED ARCHITECTURES: FROM VACCINE ADJUVANTS TO GLYCAN FOLDAMERS
… have been used both for biology and for material chemistry purpose5. The first chapter of this PhD thesis focus the attention on vaccine adjuvant semi-synthesis. Vaccines are one of the oldest treatments in medicine prevention, since the first vaccination was performed in the 1790s by Edward …
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Exploitation of agricultural and forestry waste: from the recovery of bioactive compounds for nutraceutical applications to the production of innovative materials
… irradiation is already a reality. The phytochemical composition of the optimized shell extracts was determined by hyphenated techniques, namely high-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric (HPLC/ESI-MS/MS) analyses. A thorough qualitative …
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NOVEL SUSTAINABLE STRATEGIES FOR THE SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) AND BIOACTIVE MOLECULES THROUGH THE EXPLOITATION OF ISOLATED ENZYMES AS BIOCATALYSTS
Green chemistry is a chemical concept, condensed in 12 principles, which aims at directing chemical industries and academic researchers to paths of sustainability, supporting the efforts in the context of the ecological transition. A valuable strategy widely recognized to fulfill most of the 12 …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… with enabling technologies such as flow chemistry, photoredox catalysis, ultrasound, and electrochemistry. In the first part, palladium-catalyzed cross-coupling reactions involving highly reactive organolithium reagents are investigated under continuous-flow conditions, demonstrating how …
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ELECTROCHEMICAL ORGANIC TRANSFORMATIONS: FROM THE DEVELOPMENT OF ENANTIOSELECTIVE STRATEGIES TO CONTINUOUS-FLOW METHODOLOGIES
… and scalability. This thesis explores electrochemical strategies for C(sp2)-C(sp3) bond formation, rearrangements, and C-Cl bond construction in both aliphatic and (hetero)aromatic frameworks. In the first part, the enantioselective α-chlorination of aldehydes is revisited by replacing …
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SHAPING ORGANIC SYNTHESIS WITH LIGHT-DRIVEN PROCESSES
The use of photons to perform photochemical transformations has become an important research topic. The selective and mild generation of highly reactive intermediates, such as radicals, has led to the development of synthetic methods active also on complex molecules. The presented thesis is divided …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
… that bridge the gap between nature’s diverse chemical landscape and the evolving demands of modern medicine. By employing a synergy between total synthesis, innovative molecule design and targeted modifications, this Ph.D. thesis aims to provide different approaches to the conceptualization …
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