Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Settore BIOS-15/A - Microbiologia"”.
-
ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
Hepatitis B virus (HBV) is a hepatotropic virus that can cause both acute and chronic liver infection. According to the World Health Organization, 254 million people were living with chronic hepatitis B virus (CHB) infection in 2022, with approximately 1.2 million new cases each year. While …
-
Prokaryotic diversity and ecosystem functioning in hypersaline environment: a metagenomic study of the Cagliari salterns
… Molentargius (SM) – located approximately 15 km apart and exposed to nearly identical climatic conditions, making them an ideal system to investigate how saltwork management shapes microbial diversity across a salinity gradient. Water (1L) and sediment (50g) samples were obtained from …
-
Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
The recent SARS-CoV-2 pandemic highlighted the lack in pandemics preparedness for hCoVs potential future spillovers and for other (+)ssRNA viruses that still lack approved pharmacological treatments such as Flaviviruses. Small molecule development stands out as the most promising approach, as it …
-
Identification and Characterization of the Mechanisms of Action of Novel Antiviral Compounds Targeting the Minimal Replication-Transcription Complex of SARS-CoV-2
After its emergence in 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified as the etiologic agent of COVID-19, a potentially fatal respiratory illness in Wuhan, China, which rapidly spread to the entire world. The pandemic has had dramatic economic, social and …
-
PEPTIDOGLYCAN REMODELLING FACTORS: KEY PLAYERS IN CELL DIVISION AND HOMEOSTASIS MAINTENANCE OF ESCHERICHIA COLI
In Escherichia coli, the structural integrity and coordinated growth of the cell envelope are crucial for survival, especially under environmental stress conditions. The lipopolysaccharide-containing outer membrane (OM) acts as a selective barrier against toxic molecules and provides additional …
-
IMPROVEMENT OF METAGENOMIC TECHNIQUES TO BETTER UNDERSTAND THE ROLE OF CANDIDATE PHYLA RADIATION IN FOOD ALLERGIES
Food allergies are local or systemic reactions that occur after the ingestion of normally innocuous food antigens (allergens) and can be triggered by various factors. The oral microbiota plays a critical role in the development of immune tolerance and is one of the factors involved. During my PhD I …
-
THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
T lymphocytes comprise diverse subsets which differ in phenotype, function and maturation level. Among them, T memory stem cells (TSCM) represent the more developmentally immature subpopulation of the memory pool, endowed with longevity, self-renewing capacity and multipotency, other than recall …
-
FUNCTIONAL CHARACTERIZATION OF THE INTERACTION BETWEENP. AERUGINOSA AND DENDRITIC CELLS TRIGGERING THE DIFFERENTIATION OF PATHOGENIC TH1/17 CELLS IN CYSTIC FIBROSIS.
La fibrosi cistica (CF) è una malattia genetica caratterizzata da una risposta infiammatoria cronica ed eccessiva a infezioni polmonari persistenti, prevalentemente causate da Pseudomonas aeruginosa (Pa). Nonostante l’ambiente polmonare ostile generato dalla disfunzione del CFTR, Pa è in grado …
-
DECIPHERING THE ORAL MICROBIOTA IN FOOD ALLERGY: INSIGHTS INTO THE CANDIDATE PHYLA RADIATION AND NOVEL METHODOLOGICAL APPROACHES
Food allergies are abnormal immune reactions to otherwise harmless food antigens, influenced by multiple factors, including the oral microbiota. During my PhD, I contributed to studies investigating the oral microbiota in food-allergic children, with a particular focus on the Candidate Phyla …
-
INVESTIGATION OF ANTIBIOFILM AND ANTIVIRULENCE ACTIVITY OF 5-FLUOROCYTOSINE IN ESCHERICHIA COLI
… the possible perturbation of de novo pyrimidine biosynthesis by 5-FC. Indeed, exposure to 5-FC resulted in a ca. 2-fold reduction of UMP intracellular levels, while not affecting the ATP nucleotide pool, thus suggesting a specific effect on the UMP biosynthetic pathway. Consistently, expression …
-
DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
Crohn’s disease (CD) is a chronic inflammatory disorder characterized by an aberrant inflammatory response against a dysbiotic gut microbiota. Especially, intestinal enrichment of the adherent-invasive Escherichia coli strain (AIEC), together with a dysregulated activation of the IL-23/pTh17 axis, …