Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Settore BIOS-11/A - Farmacologia"”.
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EXPOSURE TO STRESS EARLY IN LIFE AND ENHANCED RISK TO DEVELOP MOOD AND METABOLIC DISORDERS LATER IN LIFE: IDENTIFICATION OF THE COMMON PERIPHERAL AND CENTRAL MECHANISMS
… upregulation of stress-related markers (FoxO1, 11β- HSD1) in the brain and liver. In contrast, resilient males demonstrated better metabolic and anti-inflammatory responses, such as increased ADIPOR1 and IL4R expression, indicating effective stress management. Additionally, the liver of …
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
Rabphilin3A (Rph3A) is a synaptic protein essential for regulating exo- and endocytosis processes at presynaptic terminals and dendritic spines. It promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A …
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THE EFFECTS OF MYOCARDIAL INFARCTION ON NEUROINFLAMMATION: FOCUS ON THE ROLE OF EXTRACELLULAR VESICLES
Cardiovascular diseases (CVDs) are considered the leading cause of premature death globally, with an estimated 17 million deaths yearly, according to the World Health Organization (WHO). CVDs include a collection of diseases, most importantly cardiac ischemia. Complications following cardiac …
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IMPACT OF CHOLINE SUPPLEMENTATION ON GENETICALLY MODIFIED MICE: NEW INSIGHTS IN THE MODULATION OF CARDIOVASCULAR RISK
Le malattie cardiovascolari su base aterosclerotica sono ancora oggi una delle principali cause di morte nel mondo. Negli ultimi anni, evidenze scientifiche suggeriscono un ruolo del microbiota intestinale nella modulazione del rischio cardiovascolare e grande attenzione è stata posta sulla …
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VALORIZATION OF CHESTNUT BY-PRODUCT FOR GASTROINTESTINAL HEALTH
Castanea sativa Mill. (C. sativa) processing and pruning generate several by-products, including leaves, burs, and shells (inner and outer teguments), which are considered an important source of high-value phytochemicals. Ellagitannins from C. sativa leaf extracts have been described to impair H. …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
The selective delivery of anticancer agents to tumor tissue remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and …
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PERINATAL SEROTONERGIC MANIPULATION SHAPES LONG-TERM NEUROPSYCHIATRIC-LIKE PHENOTYPES IN RATS: MOLECULAR INSIGHTS ACROSS THE LIFESPAN.
La scarsa comprensione dei disturbi neuropsichiatrici porta spesso a diagnosi simili anche tra pazienti con sintomi differenti, riducendo l'efficacia dei trattamenti farmacologici. Le prime ricerche si sono concentrate sul sistema serotoninergico, e hanno individuato la serotonina (5-HT) come …
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TOWARD SUSTAINABLE CHEMICAL SUBSTANCES: DEVELOPMENT OF NOVEL APPROACH METHODOLOGIES TO STUDY IMMUNOTOXICITY OF PFAS
Il sistema immunitario, essenziale per la protezione contro i patogeni, la regolazione dell'infiammazione e il mantenimento dell'omeostasi tissutale, è altamente vulnerabile ai contaminanti ambientali. Tra questi, le sostanze per- e polifluoroalchiliche (PFAS) sono una vasta classe di sostanze …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
RNA-based therapeutics have emerged as a transformative class of medicines, enabling precise modulation of gene expression through sequence-defined mechanisms and offering novel therapeutic opportunities for previously intractable diseases. The potential of these drugs to address unmet …
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ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
Major Depressive Disorder (MDD) is one of the most serious conditions classified among the stress-related psychiatric disorders. Not only it is one of the leading causes of disability worldwide but is also associated with poor treatment response and high rate of relapse, which dramatically increase …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
Background: Traumatic injuries to the brain and spinal cord, including spinal cord injury (SCI), represent devastating conditions that lead to permanent loss of function, mainly due to the poor intrinsic regenerative capacity of the central nervous system (CNS). At the lesion site, the hostile …
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ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER
Background. Prostate cancer (PCa) is the second leading cause of cancer-related death in men. Although androgen deprivation therapy (ADT) is initially effective, many patients progress to castration-resistant disease with poor prognosis and limited treatment options, highlighting the need for new …
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Alcohol-induced activation of the mesocorticolimbic dopaminergic system and its modulation by energy drinks and caffeine: neurochemical, behavioral, and immunohistochemical analysis
The co-consumption of alcohol and caffeinated energy drinks among adolescents represents a growing public health concern, raising questions about its negative impact on the developing brain. Therefore, this PhD thesis aimed to investigate the effects of alcohol and caffeine, as well as alcohol and …
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
Oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) are endogenous bioactive lipids that act as selective agonists of the peroxisome proliferator-activated receptor α (PPARα), a nuclear receptor implicated in lipid metabolism, inflammation, and cancer biology. While their anti-tumour potential …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the …
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INSIGHT ON ANGPTL3 IMPACT ON HEPATIC METABOLISM AND FUNCTION
Background and aim Angiopoietin-like protein 3 (ANGPTL3) is a hepatokine, that inhibits lipoprotein and endothelial lipase with ANGPTL8, sparing the hydrolyzation of VLDLs. Its deficiency leads to higher lipases activation, resulting into hypolipidemia and protection from cardiometabolic risk. …
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THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS
… enzima bersaglio delle statine nella via biosintetica del colesterolo. L’analisi multiplex del SASP infiammatorio nel mezzo condizionato delle VSMC senescenti ha confermato la validità del nostro modello: le cellule trattate con doxorubicina e quelle vecchie hanno prodotto quantità …
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IMMUNOMODULATORY ACTIVITY OF TAMOXIFEN AND RALOXIFENE IN MACROPHAGES: IMPLICATIONS FOR HOST-DIRECTED THERAPIES IN INFECTIOUS DISEASES
Tamoxifene (TAM) e raloxifene (RAL) sono modulatori selettivi del recettore degli estrogeni (SERMs), ampiamente prescritti per il trattamento di patologie dipendenti dal recettore degli estrogeni α (ERα), come il tumore al seno ERα-positivo e l’osteoporosi. Recentemente, questi farmaci hanno …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
Background: Research highlights a complex link between diabetes-related factors such as insulin resistance, hyperglycemia, and chronic inflammation, all contributing to cognitive decline. Schizophrenia and depression, which often co-occur with type 2 diabetes mellitus, show a bidirectional …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… that the viral genome was still present after 11 weeks from the injection, suggesting a therapeutic action in preserving muscles. Indeed, AAV-shDrp1 had a positive effect on in situ muscle fragility and hypertrophy, possibly due to the observed reduction of fibrotic markers. In conclusion, the …
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