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Showing 1 to 20 of 36 for “"Settore BIOS-08/A - Biologia molecolare"”.
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SMYD3: A PLAYER IN STEMNESS AND CHROMOSOME INSTABILITY IN TRIPLE NEGATIVE BREAST CANCER
La metilasi delle lisine SMYD3 risulta essere over espressa in diversi tipi di tumore, e legata alla transizione epitelio-mesenchimale (EMT) (1). Inoltre, le cellule staminali del cancro (CSCs) sono cellule iniziatrici del tumore importanti nella formazione di metastasi e correlate all’EMT (2). Il …
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ASSESSMENT OF CELL AND METABOLIC IMPACT OF MICROTUBULE TARGETING AGENTS (MTA) IN NEURODEGENERATION AND NEURON MODELS.
Parkinson’s disease (PD) is primarily characterized by its sporadic onset, with 80–85% of cases occurring without a clear genetic cause, classified as idiopathic. The complexity of PD’s pathogenesis makes it challenging to identify a single molecular mechanism responsible for the disease. Rather, …
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FUNCTIONAL STUDY OF THE NONCODING REGULOME OF THE NUCLEAR FACTOR Y IN HUMAN CANCER
… Da un lato, abbiamo caratterizzato a livello molecolare e cellulare NFYC-AS1, valutandone l’espressione, la struttura del trascritto e la funzione biologica. Inoltre, abbiamo analizzato il suo meccanismo d’azione impiegando diverse strategie di silenziamento, ovvero gli oligonucleotidi …
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STRUCTURE-BASED APPROACHES TO DATA-DRIVEN PROTEIN FOLDING, AGGREGATION, AND SELF-ASSEMBLY
Predicting protein dynamics on a molecular level is central to understanding and ultimately controlling the biomolecular machines that govern life. Despite advances in molecular dynamics and AI-based structure prediction, the accurate and efficient simulation of complex self-assembly processes - …
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A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS
The immune-suppressive tumor microenvironment (TME) is both hypoxic and enriched with Treg. Their function in hypoxia has been poorly characterized. Definition of Treg responses to hypoxia would enable their selective targeting in cancer therapy, bypassing potential systemic adverse effects. We …
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CHROMATIN DISRUPTION IN HUNTINGTON'S DISEASE ALTERS DEVELOPMENT AND PRECEDES NEUROPATHOLOGY
La Corea di Huntington (MH) è una malattia neurodegenerativa causata da un’espansione del tratto CAG nel gene Huntingtina (HTT), che porta alla formazione di un tratto di glutammine eccessivamente lungo nell’HTT mutata (mHTT). Sebbene la manifestazione clinica si osservi generalmente in età …
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SECURE PLANT FERTILITY IN A CHANGING CLIMATE
The megaspore mother cell (MMC) development is a crucial step for plant reproduction. MMC specification is regulated by hormones, and many genes are involved. SPOROCYTELESS/NOZZLE (SPL/NZZ) is considered the master regulator of this process since its mutant cannot specify the MMC. It encodes a …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
Rett Syndrome (RTT) is a severe neurodevelopmental disorder and the leading cause of intellectual disability in females with 1 in 10,000 births being affected. The symptoms start to manifest in between 6 and 18 months of age and these include intellectual disability, epilepsy and impairments of …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates …
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LINE1 MODULATE HUMAN T CELL FUNCTION BY REGULATING PROTEIN SYNTHESIS DURING LIFE SPAN
Le cellule T costituiscono una popolazione che cambia in composizione e funzione durante la vita umana per rispondere efficacemente a vari ambienti e sfide immunitarie. Le cellule T neonatali rappresentano una popolazione distinta di cellule T naïve ad attivazione rapida, prevalentemente composta …
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INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.
It is now well established that the autophagy pathway, responsible for clearing damaged proteins and organelles, progressively declines in normal aging and in neurodegenerative diseases, leading to toxic protein aggregate accumulation. Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
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MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT
Mitochondrial diseases (MDs) are a group of rare inherited disorders caused by defective oxidative phosphorylation (OXPHOS) and defined by a wide range of clinical phenotypes. MDs show extreme genetic heterogeneity, which makes the development of efficient treatments particularly difficult. Indeed, …
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CANCERHUBS: A NETWORK-CENTRIC FRAMEWORK FOR CANCER GENE PRIORITISATION
Il cancro è una patologia complessa che trae origine da mutazioni genetiche, le quali rappresentano il principale evento scatenante della trasformazione neoplastica. Tuttavia, tali lesioni non sono di per sé sufficienti a spiegare la complessità della malattia, che emerge dall'interazione con …
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STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA
D-aspartate (D-Asp) is abundant in mammal brain at embryonal level while it rapidly decreases at post-natal stages due to the enhanced activity of D-aspartate oxidase (DASPO). D-Asp participates to glutamatergic neurotransmission and alterations of physiological metabolism are linked to …
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CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
One of the hallmarks of cancer is the evasion of the anti-tumor immune response. Cancer cells orchestrate several mechanisms to grow unchecked while promoting a suppressive tumor microenvironment (TME). In this context, CD4+ FOXP3+ regulatory T cells (Tregs) have emerged as a major …
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LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
Tumor infiltrating regulatory T cells (TI-Tregs) exhibit a complex interplay with various cell types, including tumor cells, immune cells, and stromal cells thereby promoting tumor growth and invasion. TI-Treg are transcriptionally and epigenetically adapted to the hostile tumor microenvironment …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
Weaver syndrome (WVS) is a rare, autosomal dominant multisystem disorder, characterized by pre- and post-natal overgrowth, macrocephaly, facial dysmorphisms and varying degrees of intellectual disability. WVS’ genetic cause was identified in heterozygous mutations in Polycomb repressive complex 2 …
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ANTIMICROBIAL PEPTIDES FOR A SUSTAINABLE AGRICULTURE
L'agricoltura moderna si basa principalmente sull'utilizzo di pesticidi chimici per proteggere le colture da patogeni e parassiti. Tuttavia, l'uso massiccio di questi composti ha portato all'insorgenza di ceppi resistenti, all'inquinamento ambientale e al danno agli organismi non bersaglio. Per …
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MULTIPLE MYELOMA PLASMA CELL PROFILING: INTEGRATED SINGLE-CELL RNA AND VDJ SEQUENCING APPROACHES UNCOVER NOVEL CLINICAL INSIGHTS
Il Mieloma Multiplo (MM) è una neoplasia ematologica caratterizzata dalla proliferazione di plasmacellule (PCs) nel midollo osseo (BM) che secernono anticorpi. È preceduto da stadi asintomatici definiti come Gammapatia Monoclonale di Significato Indeterminato (MGUS) o Mieloma Multiplo Smouldering …
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CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION
Kdm6a is an X-linked gene encoding a lysine demethylase involved in epigenetic regulation of gene expression. It catalyzes the demethylation of histone H3 lysine-27, counteracting the function of Polycomb Repressive Complex 2 (PRC2). Kdm6a plays a key role in transcriptional activation of genes …
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