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Showing 1 to 20 of 29 for “"Settore BIOS-07/A - Biochimica"”.
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BIOBASED APPROACHES AT MODULATING THE INTERACTION BETWEEN LEGUMES BIOPOLYMERS AND BIOACTIVES: A PERSPECTIVE FOR THE PRODUCTION OF BAKED GOODS
Nowadays, with the increasing consumer demand for healthy foods, legumes, pseudocereals like buckwheat, and cereals like sorghum, have gained popularity as a potential component of functional foods. These crops are characterized by well-balanced nutritional profile, made by proteins, carbohydrates, …
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A CORRELATIVE CRYO-ELECTRON TOMOGRAPHY APPROACH TO STUDY BRD4-NUT CHROMATIN CONDENSATES ACROSS SCALES
Biomolecular condensates (BMCs) are key organizers of cellular functions, and dysregulation of these compartments has been linked to neurodegenerative disorders and cancer. One example is NUT carcinoma, in which the fusion oncoprotein BRD4-NUT leads to aberrant chromosomal megadomains with …
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ARCHITECTURE AND RNA RECOGNITION BY THE EUKARYOTIC M6A METHYLTRANSFERASE COMPLEX
RNA modifications are critical post-transcriptional regulators of gene expression, influencing diverse biological functions. Among them, N6-methyladenosine (m6A) is one of the most abundant mRNA modifications and contributes to key cellular processes, including mRNA processing, translation, and …
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A ¿GREEN PATH¿ STRATEGY FOR COMPLETE RECOVERY OF BUCKWHEAT PROCESSING BYPRODUCTS
This PhD thesis fits in the general framework of the so-called “circular bioeconomy” and focuses on the valorization of buckwheat husk, an agro-industrial by-product generated during the milling process. The main objective of the work was to identify and develop innovative strategies for the …
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
Polycomb group (PcG) proteins are chromatin modifiers that epigenetically regulate the transcription of key developmental genes involved in embryogenesis, pluripotency and tumorigenesis. Alterations in their activity are hallmarks in developmental disorders and cancer as chromatin modifiers are one …
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COMPUTATIONAL ENZYME ENGINEERING: FROM MOLECULAR MODELING TO MACHINE LEARNING
The chemical, pharmaceutical, and materials industries increasingly rely on sustainable and efficient strategies for molecular synthesis, driving the growing importance of biocatalysis in modern life sciences. Enzymes, as highly selective and efficient natural catalysts, offer significant …
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IN SILICO CHARACTERIZATION OF THE RECOGNITION MECHANISM OF RIBOFLAVIN TRANSPORTERS RFVT1, RFVT2, AND RFVT3, AND ORGANIC CATION TRANSPORTERS OCTN1 AND OCTN2
Questa tesi esplora le caratteristiche strutturali e funzionali dei trasportatori della famiglia SLC (solute carrier), identificati come promettenti bersagli per scopi farmacologici. Questi trasportatori transmembrana sono elementi fondamentali per l'omeostasi cellulare, e alterazioni nella loro …
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IS B4GALT5 DEFICIENCY A NEW CONGENITAL DISORDER OF GLYCOSYLATION?
… activity by in vitro assay, and cell GSL biosynthesis by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) were then determined. Similar analyses were also performed on patient’s serum and dermal fibroblasts. Results showed that the mutations do not impair transcript …
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NUTRITIONAL AND BIOACTIVE COMPOUNDS FROM AGRI-FOOD PRODUCTS AND BY-PRODUCTS: IN VITRO ASSESSMENT OF THEIR POTENTIAL HEALTH EFFECTS
The growing need to reduce the environmental footprint of human activities and to ensure sustainable food production has accelerated the transition toward more resource-efficient and nutritionally balanced food systems. At the same time, increasing consumer interest in healthpromoting and naturally …
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INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION
Cancer cell genomes display numerous mutation patterns that subvert genome stability. DNA repair and damage response mechanisms are responsible for maintaining stability in normal cells. One such repair mechanism involves homologous recombination (HR) proteins BRCA2 which protects DNA replication …
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A DE NOVO COMPUTATIONAL DISCOVERY PLATFORM FROM RNA TO PROTEIN
Data-driven identification and functional characterization of human transcripts and proteins remain challenging tasks in the post-genomics era. Transcriptional and post-transcriptional regulation mechanisms hugely increase RNA isoform diversity, while their contribution to protein synthesis remains …
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MOLECULAR RECOGNITION OF THYROGLOBULIN BY SORTILIN
Thyroglobulin (TG) is a large glycoprotein essential for thyroid hormone synthesis and storage. Synthesised and secreted by thyrocytes, TG forms a dimeric structure within the thyroid follicle lumen, where it undergoes iodination and hormonogenesis before being retrieved through endocytosis for …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
Maintenance of native folding is crucial for ensuring protein biological activity. Despite cells have evolved several control mechanisms to preserve folding, when they fail, proteins undergo destabilization or partial unfolding, events that favor the onset of protein misfolding diseases. These …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
… and widespread disruption of bioenergetic and biosynthetic pathways. These effects included impaired β-oxidation of fatty acids, diminished nucleotide synthesis, and defective amino acid catabolism, indicating a collapse in mitochondrial biosynthetic processes, leading to cancer cell death. …
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HEPATIC ESTROGEN RECEPTOR ALPHA ACTS AS A MOLECULAR TIMER ALIGNING LIVER METABOLISM TO PREGNANCY PROGRESSION
Il fegato è coinvolto nell’omeostasi dei macronutrienti, nell’eliminazione di sostanze tossiche e nel metabolismo dei farmaci, e gli ormoni sessuali, in particolare gli estrogeni, regolano il metabolismo epatico agendo principalmente attraverso il recettore degli estrogeni α (ERα). ERα regola con …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
BACE2 has traditionally been studied in the context of neurodegenerative diseases. However, its involvement in cancer progression has become increasingly recognized. While in melanocytes, BACE2 physiologically cleaves the PMEL protein to generate peptides that form the melanin scaffold, our group …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
Epigenetic reprogramming and chromatin structure guide differentiation and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated …
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ADVANCING IN SITU CRYO-ET TO THE NEXT DIMENSION: TOMOGRAPHY ON 3D ORGANOIDS
Interpreting how molecular organization supports cell and tissue function remains a central challenge in biology. In situ cryo-electron tomography (cryo-ET) can help to address this challenge by providing high-resolution, three-dimensional visualization of macromolecules in near-native, minimally …
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ROLE OF THE ENDOCYTIC PROTEIN EPSIN 3 IN MAMMARY GLAND TRANSFORMATION
Background: Endocytosis is a crucial mechanism regulating cellular signaling and its dysregulation is linked to cancer. We previously showed that the endocytic protein Epsin 3 (EPN3) is overexpressed in 50% of breast cancers (BC) and amplified in approximately 10% of cases. EPN3 overexpression …
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